Naringenin and quercetin – potential anti-HCV agents for NS2 protease targets

Lulu, Sajitha; Thabitha, A; Vino, S; Priya, A Mohana; Rout, Madhusmita

doi:10.1080/14786419.2015.1020490

Cited by 32 publications

(27 citation statements)

References 9 publications

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“…NS2 is a transmembrane protein of 21-23 kDa that is not required for RNA replication but that is vital to produce infectious viruses in vitro , and it acts as an apoptosis inhibitor[ 191 , 209 ]. Using a docking analysis, it has been identified that naringenin could be an NS2 protease inhibitor.…”

Section: Antiviral Properties Of Naringeninmentioning

confidence: 99%

Beneficial effects of naringenin in liver diseases: Molecular mechanisms

Hernández-Aquino

Muriel

2018

WJG

260

176

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Liver diseases are caused by different etiological agents, mainly alcohol consumption, viruses, drug intoxication or malnutrition. Frequently, liver diseases are initiated by oxidative stress and inflammation that lead to the excessive production of extracellular matrix (ECM), followed by a progression to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). It has been reported that some natural products display hepatoprotective properties. Naringenin is a flavonoid with antioxidant, antifibrogenic, anti-inflammatory and anticancer properties that is capable of preventing liver damage caused by different agents. The main protective effects of naringenin in liver diseases are the inhibition of oxidative stress, transforming growth factor (TGF-β) pathway and the prevention of the transdifferentiation of hepatic stellate cells (HSC), leading to decreased collagen synthesis. Other effects include the inhibition of the mitogen activated protein kinase (MAPK), toll-like receptor (TLR) and TGF-β non-canonical pathways, the inhibition of which further results in a strong reduction in ECM synthesis and deposition. In addition, naringenin has shown beneficial effects on nonalcoholic fatty liver disease (NAFLD) through the regulation of lipid metabolism, modulating the synthesis and oxidation of lipids and cholesterol. Moreover, naringenin protects from HCC, since it inhibits growth factors such as TGF-β and vascular endothelial growth factor (VEGF), inducing apoptosis and regulating MAPK pathways. Naringenin is safe and acts by targeting multiple proteins. However, it possesses low bioavailability and high intestinal metabolism. In this regard, formulations, such as nanoparticles or liposomes, have been developed to improve naringenin bioavailability. We conclude that naringenin should be considered in the future as an important candidate in the treatment of different liver diseases.

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Section: Antiviral Properties Of Naringeninmentioning

confidence: 99%

Beneficial effects of naringenin in liver diseases: Molecular mechanisms

Hernández-Aquino

Muriel

2018

WJG

260

176

View full text Add to dashboard Cite

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“…An additional anti-HCV activity by quercetin-based treatment was recently suggested [ 101 ]. Lulu et al predicted the 3D structure HCV NS2 protein and performed docking studies to identify phytochemical compounds which could have strong affinity towards its protease.…”

Section: Plant-derived Compounds With Anti-hcv Propertiesmentioning

confidence: 99%

“…Naringenin was also co-incubated with WY14643 and no increased effect was observed, demonstrating the possible effect of naringenin in PPARα activation. More recently, Lulu et al analysed by molecular docking studies the structural interactions between naringenin and the protein NS2 protease [ 101 ]. They demonstrated that naringenin exhibited a lower minimum binding energy (− 7.97 kcal/mol) than RBV (− 5.89 kcal/mol) to bind to NS2 protein, suggesting that naringenin requests a lesser amount of energy to disrupt HCV NS2 protein.…”

Section: Plant-derived Compounds With Anti-hcv Propertiesmentioning

confidence: 99%

Plant-derived antivirals against hepatitis c virus infection

Jardim

Shimizu

Rahal

et al. 2018

Virol J

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Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 million people are or have previously been infected worldwide. There is no effective vaccine for prevention of HCV infection; however, a number of drugs are available for the treatment of infection. The availability of direct-acting antivirals (DAAs) has dramatically improved therapeutic options for HCV genotype 1. However, the high costs and potential for development of resistance presented by existing treatment demonstrate the need for the development of more efficient new antivirals, or combination of therapies that target different stages of the viral lifecycle. Over the past decades, there has been substantial study of compounds extracted from plants that have activity against a range of microorganisms that cause human diseases. An extensive variety of natural compounds has demonstrated antiviral action worldwide, including anti-HCV activity. In this context, plant-derived compounds can provide an alternative approach to new antivirals. In this review, we aim to summarize the most promising plant-derived compounds described to have antiviral activity against HCV.

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“…Recent studies on C. intybus have found some of the important constituents such as caffeic acid derivatives, phenylacetic acid esters, fructooligosaccharides, flavonoids, coumarins, polyphenol, cichoriosides, sonchuside A, ixerisosides, magnolialide, eudesmanolides, bitter sesquiterpene lactones, inulin, and vitamins (El-Lakany et al 2004; Hussain et al 2011; Kumari, Ali, & Aeri 2012; Kirillov et al 2017; Lulu et al 2016). In this paper, we report the isolation and characterization of one new 28 β -hydroxytaraxasterol besides six known compounds from the aerial parts of C. intybus .…”

Section: Introductionmentioning

confidence: 99%

Chemical and biological studies onCichorium intybusL.

Satmbekova

Radhakrishnan

Orazbekov

et al. 2017

Natural Product Research

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Cichorium intybus L. (Asteraceae family) is a worldwide grown plant known as chicory. In traditional medicine, this plant is used as diuretic, anti-inflammatory, digestive, cardiotonic and liver tonic. Chromatographic purification of the supercritical fluid extract of aerial parts of C. intybus on silica gel column led to isolation of three compounds: new compound, 28β-hydroxytaraxasterol (I), and two known compounds usnic acid (II), and β-sitosterol (III). Purification of the ethanolic extract of aerial parts of this plant on silica gel column chromatography yielded four compounds: 1,3-dioleylglycerate (IV), sitoindoside II (V), 11β-13-dihydrolactucin (VI), and β-sitosterol-3-O-glucoside (VII). The structures of the isolated compounds were determined by their 1D, 2D NMR and MS spectral data. All the fractions and isolated compounds were tested for cannabinoid and opioid receptor binding, as well as antibacterial, antifungal, and antimalarial activities. Compound I showed moderate activity (60.5 % displacement) towards CB1 receptor.

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Naringenin and quercetin – potential anti-HCV agents for NS2 protease targets

Cited by 32 publications

References 9 publications

Beneficial effects of naringenin in liver diseases: Molecular mechanisms

Beneficial effects of naringenin in liver diseases: Molecular mechanisms

Plant-derived antivirals against hepatitis c virus infection

Chemical and biological studies onCichorium intybusL.

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