Naringenin ameliorates progression of endometriosis by modulating Nrf2/Keap1/HO1 axis and inducing apoptosis in rats

Kapoor, Richa; Sirohi, Vijay Kumar; Gupta, Kanchan; Dwivedi, Anila

doi:10.1016/j.jnutbio.2019.05.003

Cited by 39 publications

(38 citation statements)

References 48 publications

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“…This study extends previous findings that P. macrocarpa extract can trigger apoptosis of endometrial cells [ 28 ]. Previous studies have shown that naringenin can inhibit endometrial cell proliferation from endometriosis lesions [ 39 ]. We proved that P. macrocarpa contains (±) -naringenin and its derivatives, (−) - 8-prenylnaringenin can inhibit proliferation and apoptosis, which can also suppress the development of peritoneal endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical characteristics from Phaleria macrocarpa and its inhibitory activity on the peritoneal damage of endometriosis

Maharani

Lajuna²,

Yuniwati³

et al. 2021

Journal of Ayurveda and Integrative Medicine

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Background Endometriois represents a gynecological disease that still becomes an issue in community. Phaleria macrocarpa is a plant native to Indonesia that contains an antioxidant substance, which may serve as apoptotic modulator and useful for angiogenesis. Objective This study aims to evaluate the effects of flavonoid isolates from P. macrocarpa (PM) on the development of granulomas, apoptosis, proliferation, and angiogenesis of the disease. Material and methods Total thirty mice ( Mus musculus ) were categorized into six groups, including the normal group (without any treatment), EMT (endometriosis) group, and EMT group treated with PM flavonoid isolates. Identification of the active compounds of P. macrocarpa was done using LC-HRMS. Measurement of granuloma scores and vascular density was done histologically. Apoptosis and proliferation analysis was performed by immunohistochemical techniques. Results There was an increase in granulomas, proliferation, and apoptosis in the peritoneal tissues of the endometriosis model. This change can be normalized by extract of P. macrocarpa . Conclusion We concluded that the flavonoid isolates from P. macrocarpa can suppress the growth of endometriosis lesions through normalization of proliferation and apoptosis. Thus, the P. macrocarpa flavonoid can be used as an alternative to inhibit the development of endometriosis.

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Section: Discussionmentioning

confidence: 99%

Phytochemical characteristics from Phaleria macrocarpa and its inhibitory activity on the peritoneal damage of endometriosis

Maharani

Lajuna²,

Yuniwati³

et al. 2021

Journal of Ayurveda and Integrative Medicine

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“…The flavonoid naringenin is found in citrus fruits and exhibits antinociceptive, antioxidant, and anti-inflammatory properties [86, 87]. The effects of naringenin are mediated via various physiological actions, including inhibition of NF-κB activation [86], induction of Nrf2/heme oxygenase (HO)-1 pathway [87], activation of the NO-cGMP-cGMP-dependent protein kinase (PKG)-ATP-sensitive potassium channel (KATP) signaling pathway [87], reduction of the expression of matrix metalloproteinase (MMP)-2 and MMP-9, and loss of mitochondrial membrane potential [88]. Naringenin is a promising compound to treat inflammatory pain and leukocyte recruitment [86].…”

Section: Methodsmentioning

confidence: 99%

“…Naringenin is a promising compound to treat inflammatory pain and leukocyte recruitment [86]. The in vitro studies and rat experimental models revealed that naringenin is a candidate drug for the treatment of endometriosis [88].…”

Section: Methodsmentioning

confidence: 99%

Nonhormonal Treatment for Endometriosis Focusing on Redox Imbalance

Nagayasu

Imanaka

Kimura

et al. 2021

Gynecol Obstet Invest

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The aim of this review is to investigate the oxidant/antioxidant status and its regulatory mechanisms in patients with endometriosis and to summarize the antioxidant therapy as an alternative to hormonal therapy for endometriosis. Each keyword alone or in combination was used to search from PubMed and Embase by applying the filters of the title and the publication years between January 2000 and March 2020. Endometriosis is a chronic inflammatory disease characterized by repeated episodes of hemorrhage. Methemoglobin in repeated hemorrhage produces large amounts of superoxide anion via the autoxidation of hemoglobin. Excessive free-radical production causes redox imbalance, leading to inadequate antioxidant defenses and damage to endometrial cells, but may contribute to endometrial cell growth and survival through activation of various signaling pathways. In addition, to overcome excessive oxidative stress, estradiol participates in the induction of antioxidants such as superoxide dismutase in mitochondria. Several antioxidants that suppress free radicals may be effective in endometriosis-related pain. We searched for 23 compounds and natural substances that could reduce the pain caused by superoxide/reactive oxygen species in basic research and animal models. Next, we built a list of 16 drugs that were suggested to be effective against endometriosis other than hormone therapy in preclinical studies and clinical trials. Of the 23 and 16 drugs, 4 overlapping drugs could be potential candidates for clinically reducing endometriosis-related pain caused by superoxide anion/reactive oxygen species. These drugs include polyphenols (resveratrol and polydatin), dopamine agonists (cabergoline), and statins (simvastatin). However, no randomized controlled trials have evaluated the efficacy of these drugs. In conclusion, this review summarizes the following 2 points: superoxide anion generation by methemoglobin is enhanced in endometriosis, resulting in redox imbalance; and some compounds and natural substances that can suppress free radicals may be effective in endometriosis-related pain. Further randomized clinical trials based on larger series are mandatory to confirm the promising role of antioxidants in the nonhormonal management of endometriosis.

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“…Many flavonoidic compounds, such as rutin, naringin, naringenin, or genistein, have been reported to have physiologic benefits, including inhibition of tumor angiogenesis, protection from cardiovascular disease, promotion of neural protection, anti-angiogenic activities in inflammatory, chronic, and metabolic diseases [ 15 , 16 ], and nitric oxide scavenging activity [ 10 ]. Many of these benefits coming from their special antioxidant and free radical inhibition properties [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Flavonoid Profiles of Two New Approved Romanian Ocimum Hybrids

et al. 2020

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Basil (Ocimum spp.) is a traditional herbal medicine abundant in antioxidants such as phenolic compounds. As part of a diet, this herb is proved to have some roles in decreasing the risk of cancer, and in the treatment of inflammation and neurodegenerative diseases. This study aims to explore the total phenolic and flavonoid content of two new basil hybrids growing in Romania, namely “Aromat de Buzau” (AB) and “Macedon” (MB). The antioxidant capacity of those two species was also analyzed by DPPH and cyclic voltammetry. Six different flavonoids, such as catechin (+), rutin, hyperoside, naringin, naringenin, and genistein, were separated, identified, and quantified by HPLC–DAD chromatography, for the first time, from romanian basil hybrids. The main flavonoid of the extracts was found to be naringin which is present in the highest amount (26.18 mg/kg) in “Aromat de Buzau” (O. basilicum) methanolic extract. These results suggest that dietary intake of these new hybrids can be a source of antioxidant compounds.

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Naringenin ameliorates progression of endometriosis by modulating Nrf2/Keap1/HO1 axis and inducing apoptosis in rats

Cited by 39 publications

References 48 publications

Phytochemical characteristics from Phaleria macrocarpa and its inhibitory activity on the peritoneal damage of endometriosis

Phytochemical characteristics from Phaleria macrocarpa and its inhibitory activity on the peritoneal damage of endometriosis

Nonhormonal Treatment for Endometriosis Focusing on Redox Imbalance

Flavonoid Profiles of Two New Approved Romanian Ocimum Hybrids

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