Nardostachys jatamansi Protects Against Cerulein-Induced Acute Pancreatitis

Bae, Gi‐Sang; Park, Hee-Je; Kim, Doyun; Song, Je-Moon; Kim, Tae-Hyeon; Oh, Hyo-Jeong; Yun, Ki-Jung; Park, Raekil; Lee, Jung-Ho; Shin, Byung‐Cheul; Sim, Hee‐Jung; Hong, Seon-Pyo; Song, Ho‐Joon; Park, Sung‐Joo

doi:10.1097/mpa.0b013e3181bd93ce

Cited by 32 publications

(18 citation statements)

References 26 publications

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“…The dysregulation of IL-6 production or turnover can lead to chronic elevations of cytokines and many pathologic consequences [23]. In accordance with our previous report [4], the treatment of NJ inhibited the production of inflammatory mediators, such as TNF-a, IL-1b, and IL-6, in vivo and in vitro (Figs. 1 and 2).…”

Section: Discussionsupporting

confidence: 83%

“…It has been used in the treatment of digestive diseases. Furthermore, the pharmacologic protective actions of NJ against Parkinson disease, liver damage, neuronal damage, and acute pancreatitis have been reported [4,20]. In the present study, we observed the protective effects of NJ in LPS-induced endotoxin shock.…”

Section: Discussionmentioning

confidence: 48%

“…Alcoholic extracts of NJ are protective against thiacetamide-induced liver damage in rats [1]. Our previous report showed that water extracts of NJ reduced cerulein-induced acute pancreatitis [4]. However, the effect of NJ on lipopolysaccharide (LPS)-induced endotoxin shock has not been examined.…”

Section: Introductionmentioning

confidence: 97%

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The roots of Nardostachys jatamansi inhibits lipopolysaccharide-induced endotoxin shock

Bae

Seo²,

Kim

et al. 2010

J Nat Med

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Nardostachys jatamansi (NJ) has been used in the treatment of inflammatory diseases. However, it is not clear how NJ produces anti-inflammatory effects. In the present study, using an experimental model of lipopolysaccharide (LPS)-induced endotoxin shock, the protective effects and mechanisms of action of NJ were investigated. The water extract of roots of NJ was administrated to mice orally (1, 5, and 10 mg/kg) 1 h after or before LPS challenge. The administration of NJ inhibited LPS-induced endotoxin shock and the production of inflammatory mediators, such as interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and interferon (IFN)-α/β. Murine peritoneal macrophages were used to determine the production of inflammatory mediators. In peritoneal macrophages, NJ also inhibited LPS-induced production of inflammatory mediators, such as IL-1β, IL-6, TNF-α, and IFN-α/β. In addition, NJ reduced the activation of mitogen-activated protein kinases (MAPKs) and the level of expression of interferon regulatory factor (IRF)-1 and IRF-7 mRNA. Furthermore, post-treatment with NJ reduced LPS-induced endotoxin shock and the production of inflammatory mediators. These results suggest that NJ inhibits endotoxin shock by inhibiting the production of IL-1β, IL-6, TNF-α, and IFN-α/β through the inhibition of MAPKs activation and IRF induction.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 48%

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The roots of Nardostachys jatamansi inhibits lipopolysaccharide-induced endotoxin shock

Bae

Seo²,

Kim

et al. 2010

J Nat Med

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“…아토피피부염을 크게 濕熱俱盛型, 脾虛濕盛型, 血虛風燥型으로 변증 분류하는 . 감송향의 성분은 valeranone, nardosonone, nardostachone, 1-aristilene-2-one, patchouli alcohol, pinene, oleeanolic acid, b-sitisterol 등을 함유하였고 [4][5][6]30) , 감송 향의 효능에 관한 연구는 대부분 신경계와 관련된 연 구로서 뿌리 및 근경 (Nardostachytis rhizoma) 추출물의 진정효과 31) , 신경세포 분화와 관련된 보고 [32][33][34][35] , 급성 췌 장염 억제 16,17,36) , 항산화 및 항스트레스 작용 37,38) , 항박 테리아, 항진균작용 39) , 염증 및 면역에 관한 보고 …”

Section: Tnf-α 생성 조절에 Nj의 효과를 측정하기 위하여unclassified

Effects of Nardostachys Jatamansi on Atopic Dermatitis-like Skin Lesions

Min

Park²

2012

The Journal of Korean Oriental Pediatrics

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ObjectivesNJ is being used to treat inflammatory diseases in Korea. In this study, we attempted to evaluate the effects of NJ on atopic dermatitis (AD)-like lesions and mast cell-mediated allergy inflammation in vivo and in vitro. Methods and ResultsWe investigated to ascertain the pharmacological effects of NJ on 2,4-dinitrofluorobenzene (DNFB)-induced allergic reactions under in vivo conditions. Additionally, to find possible explanations for the anti-inflammatory mechanisms of NJ, we evaluated the regulatory effects of NJ on the level of inflammatory mediators in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1). ConclusionsNJ inhibited the production of the inflammatory cytokines (IgE, IL-6, IL-8 and TNF-α) significantly in vivo and in vitro.

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“…The deactivation or extermination the PSCs is well-known treatment of CP (6). We already have reported that Nardostachys jatamansi (NJ) has protective effects on acute pancreatitis, and sepsis (7,8). We have used the root decoction in the evaluation of NJ's effects.…”

Section: Introductionmentioning

confidence: 99%

The inhibitory effects of Nardostachys jatamansi on alcoholic chronic pancreatitis

Bae¹,

Park²,

Koo³

et al. 2012

BMB Reports

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Nardostachys jatamansi (NJ) belonging to the Valerianaceae family has been used as a remedy for gastrointestinal inflammatory diseases for decades. However, the potential for NJ to ameliorate alcoholic chronic pancreatitis (ACP) is unknown. The aim of this study was to examine the inhibitory effects of NJ on ACP. C57black/6 mice received ethanol injections intraperitoneally for 3 weeks against a background of cerulein-induced acute pancreatitis. During ACP, NJ was ad libitum administrated orally with water. After 3 weeks of treatment, the pancreas was harvested for histological examination. NJ treatment increased the pancreatic acinar cell survival (confirmed by amylase level testing) and reduced collagen deposition and pancreatic stellate cell (PSC) activation. In addition, NJ treatment reduced the activation but not death of PSC. In conclusion, our results suggest that NJ attenuated ACP through the inhibition of PSC activation. [BMB Reports 2012; 45(7): 402-407]

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Nardostachys jatamansi Protects Against Cerulein-Induced Acute Pancreatitis

Abstract: These results suggest that N. jatamansi attenuates the severity of AP and pancreatitis-associated lung injury.

Cited by 32 publications

References 26 publications

The roots of Nardostachys jatamansi inhibits lipopolysaccharide-induced endotoxin shock

The roots of Nardostachys jatamansi inhibits lipopolysaccharide-induced endotoxin shock

Effects of Nardostachys Jatamansi on Atopic Dermatitis-like Skin Lesions

The inhibitory effects of Nardostachys jatamansi on alcoholic chronic pancreatitis

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