Nardostachys jatamansi (D.Don) DC.-Challenges and opportunities of harnessing the untapped medicinal plant from the Himalayas

Dhiman, Nisha; Bhattacharya, Amita

doi:10.1016/j.jep.2019.112211

Cited by 42 publications

(24 citation statements)

References 69 publications

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“…Thus, p-coumaric and cinnamic acids known for their role in lignin biosynthesis were significantly high in the roots at 15 °C. Nardostachys jatamansi is known to have a wide array of medicinal properties that had remained unaccounted for till date 3 . Up to now, terpenoids mainly, sesquiterpenes were considered to be the major group of secondary metabolites responsible for the various medicinal properties of N. jatamansi.…”

Section: Discussionmentioning

confidence: 99%

“…Such information is important for a critically endangered plant like N. jatamansi. The plant is uprooted for its roots and rhizomes from wild because of its immense therapeutic use in the Indian, Chinese, Japanese, Tibetan and other traditional systems of medicine 3 . As per National Medicinal Plant Board, Government of India, marketing and trade report, the annual demand for the plant is about 500-1000 metric tons of rhizomes 4 .…”

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confidence: 99%

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De novo transcriptome analysis of the critically endangered alpine Himalayan herb Nardostachys jatamansi reveals the biosynthesis pathway genes of tissue-specific secondary metabolites

Dhiman

Kumar

et al. 2020

Sci Rep

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The study is the first report on de novo transcriptome analysis of Nardostachys jatamansi, a critically endangered medicinal plant of alpine Himalayas. Illumina GAIIx sequencing of plants collected during end of vegetative growth (August) yielded 48,411 unigenes. 74.45% of these were annotated using UNIPROT. GO enrichment analysis, KEGG pathways and PPI network indicated simultaneous utilization of leaf photosynthates for flowering, rhizome fortification, stress response and tissue-specific secondary metabolites biosynthesis. Among the secondary metabolite biosynthesis genes, terpenoids were predominant. UPLC-PDA analysis of in vitro plants revealed temperature-dependent, tissue-specific differential distribution of various phenolics. Thus, as compared to 25 °C, the phenolic contents of both leaves (gallic acid and rutin) and roots (p-coumaric acid and cinnamic acid) were higher at 15 °C. These phenolics accounted for the therapeutic properties reported in the plant. In qRT-PCR of in vitro plants, secondary metabolite biosynthesis pathway genes showed higher expression at 15 °C and 14 h/10 h photoperiod (conditions representing end of vegetative growth period). This provided cues for in vitro modulation of identified secondary metabolites. Such modulation of secondary metabolites in in vitro systems can eliminate the need for uprooting N. jatamansi from wild. Hence, the study is a step towards effective conservation of the plant.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

De novo transcriptome analysis of the critically endangered alpine Himalayan herb Nardostachys jatamansi reveals the biosynthesis pathway genes of tissue-specific secondary metabolites

Dhiman

Kumar

et al. 2020

Sci Rep

Self Cite

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“…Nardostachys jatamansi has been widely used as a folk medicine in China, Nepal, Bhutan, India, and Japan for the treatment of pain, altitude sickness, fever, and wounds [ 21 ]. The roots of N. jatamansi have neuroprotective, sedative, and analgesic properties, and a variety of active ingredients have been separated from N. jatamansi , in which sesquiterpenoids, essential oils, iridoids, triterpenoids, flavonoid, coumarin, and lignin are the main chemical constituents [ 21 , 22 , 23 ]. The anti-inflammatory activities of sesquiterpenoids, terpenic coumarin, and phytosterol such as nardosinanones and narchinol might contribute to the analgesic activities produced by N. jatamansi [ 21 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

(−)-Naringenin 4′,7-dimethyl Ether Isolated from Nardostachys jatamansi Relieves Pain through Inhibition of Multiple Channels

Meng

Zhang

et al. 2022

Molecules

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(−)-Naringenin 4′,7-dimethyl ether ((−)-NRG-DM) was isolated for the first time by our lab from Nardostachys jatamansi DC, a traditional medicinal plant frequently used to attenuate pain in Asia. As a natural derivative of analgesic, the current study was designed to test the potential analgesic activity of (−)-NRG-DM and its implicated mechanism. The analgesic activity of (−)-NRG-DM was assessed in a formalin-induced mouse inflammatory pain model and mustard oil-induced mouse colorectal pain model, in which the mice were intraperitoneally administrated with vehicle or (−)-NRG-DM (30 or 50 mg/kg) (n = 10 for each group). Our data showed that (−)-NRG-DM can dose dependently (30~50 mg/kg) relieve the pain behaviors. Notably, (−)-NRG-DM did not affect motor coordination in mice evaluated by the rotarod test, in which the animals were intraperitoneally injected with vehicle or (−)-NRG-DM (100, 200, or 400 mg/kg) (n = 10 for each group). In acutely isolated mouse dorsal root ganglion neurons, (−)-NRG-DM (1~30 μM) potently dampened the stimulated firing, reduced the action potential threshold and amplitude. In addition, the neuronal delayed rectifier potassium currents (IK) and voltage-gated sodium currents (INa) were significantly suppressed. Consistently, (−)-NRG-DM dramatically inhibited heterologously expressed Kv2.1 and Nav1.8 channels which represent the major components of the endogenous IK and INa. A pharmacokinetic study revealed the plasma concentration of (−)-NRG-DM is around 7 µM, which was higher than the effective concentrations for the IK and INa. Taken together, our study showed that (−)-NRG-DM is a potential analgesic candidate with inhibition of multiple neuronal channels (mediating IK and INa).

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“…The roots of Vo and Nj, because of high commerce, are often fraudulently adulterated with other species [15]. In addition, confusion about the botanical nomenclature between Nj and Vj frequently has been observed, since both the species are known with the same vernacular names, and the authentication of herbal material is made more difficult by the use of dried root/rhizome samples [16].…”

Section: Introductionmentioning

confidence: 99%

“…Nj is a small, perennial herb distributed in Himalaya at an altitude of about 3000-5000 m. Its rhizome is woody and is covered with brown fibrous remains of the petioles of the radical leaves, while the roots penetrate deep in the soil. Nj has been used since ancient times by traditional medicine systems such as Ayurveda, Siddha and Unani to treat a wide range of ailments [16]. Rhizomes and roots of Nj are mainly used for various neurological disorders such as hysteria, epilepsy, and mental weakness [23].…”

Section: Introductionmentioning

confidence: 99%

Comparative and Functional Screening of Three Species Traditionally used as Antidepressants: Valeriana officinalis L., Valeriana jatamansi Jones ex Roxb. and Nardostachys jatamansi (D.Don) DC.

Cornara

Ambu

Trombetta

et al. 2020

Plants

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The essential oils (EOs) of three Caprifoliaceae species, the Eurasiatic Valeriana officinalis (Vo), the Himalayan Valeriana jatamansi (Vj) and Nardostachys jatamansi (Nj), are traditionally used to treat neurological disorders. Roots/rhizomes micromorphology, DNA barcoding and EOs phytochemical characterization were carried out, while biological effects on the nervous system were assessed by acetylcholinesterase (AChE) inhibitory activity and microelectrode arrays (MEA). Nj showed the highest inhibitory activity on AChE (IC50 67.15 μg/mL) followed by Vo (IC50 127.30 μg/mL) and Vj (IC50 246.84 μg/mL). MEA analyses on rat cortical neurons, carried out by recording mean firing rate (MFR) and mean bursting rate (MBR), revealed stronger inhibition by Nj (IC50 18.8 and 11.1 μg/mL) and Vo (16.5 and 22.5 μg/mL), compared with Vj (68.5 and 89.3 μg/mL). These results could be related to different EO compositions, since sesquiterpenes and monoterpenes significantly contribute to the observed effects, but the presence of oxygenated compounds such as aldehydes and ketones is a discriminating factor in determining the order of potency. Our multidisciplinary approach represents an important tool to avoid the adulteration of herbal drugs and permits the evaluation of the effectiveness of EOs that could be used for a wide range of therapeutic applications.

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Nardostachys jatamansi (D.Don) DC.-Challenges and opportunities of harnessing the untapped medicinal plant from the Himalayas

Cited by 42 publications

References 69 publications

De novo transcriptome analysis of the critically endangered alpine Himalayan herb Nardostachys jatamansi reveals the biosynthesis pathway genes of tissue-specific secondary metabolites

De novo transcriptome analysis of the critically endangered alpine Himalayan herb Nardostachys jatamansi reveals the biosynthesis pathway genes of tissue-specific secondary metabolites

(−)-Naringenin 4′,7-dimethyl Ether Isolated from Nardostachys jatamansi Relieves Pain through Inhibition of Multiple Channels

Comparative and Functional Screening of Three Species Traditionally used as Antidepressants: Valeriana officinalis L., Valeriana jatamansi Jones ex Roxb. and Nardostachys jatamansi (D.Don) DC.

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