Nardosinanone N suppresses LPS-induced macrophage activation by modulating the Nrf2 pathway and mPGES-1

Lio, Chon-Kit; Luo, Jin-Fang; Shen, Xiu‐Yu; Dai, Yi; Machado, Jorge; Xie, Yu; Yao, Yun-Da; Yu, Yang; Liu, Jianxin; Yao, Xin‐Sheng; Luo, Pei; Zhou, Hua

doi:10.1016/j.bcp.2019.113639

Cited by 13 publications

(4 citation statements)

References 65 publications

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“…Much attention has been paid to the investigation of the development of side effects with the use of NSAIDs [19][20][21][22][23][24]. The main side effects after NSAIDs which have been covered in many studies [25][26][27][28][29][30][31][32] are gastrointestinal disorders (nausea, vomiting, abdominal pain, diarrhea, constipation, flatulence, dyspepsia, dry mouth, peptic ulcers, bleeding, perforated ulcers, anorexia, elevated liver enzymes, pancreatic damage, and hepatic damage) [33][34][35][36][37]; neurological disorders (sleep disorders, anxiety, headache, dizziness, hot flashes, and paresthesia); disorders of the cardiovascular system (increased blood pressure, palpitations, tachycardia, hypotension, and peripheral edema) [38][39][40]; allergic complications (bronchospasm, shortness of breath, skin rash, the Stevens-Johnson and Lyell syndromes, photosensitization, anaphylactic reactions, facial edema, and itching) [41,42]; disorders of the genitourinary system (nephritis or nephrotic syndrome, polyuria, menstrual disorders in women, and disorders of the prostate in men) [39]. Much attention is paid to the study of acid-dependent diseases of the gastrointestinal tract, which develop after NSAIDs use [43,44].…”

Section: Discussionmentioning

confidence: 99%

Different consequences of the treatment of osteoarthritis in gastrointestinal comorbidity with exocrine pancreatic insufficiency

Halabitska¹,

Бабинец²

2021

fmpcr

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Background. Patients with OA require attention of specialists due to the high integrative risk of acute conditions caused by the use of drugs that successfully treat chronic pain, but lead to gastrointestinal complications . Objectives. The aim of the study was to evaluate the effect of anti-inflammatory treatment of primary osteoarthritis on joint and digestive functions, as well as the trophological status of patients with osteoarthritis under conditions of comorbidity with a pathology of the gastrointestinal tract. Material and methods. The study included 87 patients with primary osteoarthritis in comorbidity with exocrine pancreatic insufficiency in gastrointestinal diseases without exacerbation. It investigated the symptoms of osteoarthritis, fecal α-elastase levels, the CO program, the GSRS questionnaire, and the parameters of the trophological status. The studied parameters were measured before and after six weeks after the start of treatment. Results. The use of NSAIDs contributes to regression of primary osteoarthritis symptoms according to the indices of the VAS, WOMAC, Leken, and Harris Hip tests (p < 0.05), but it has a negative effect on the levels of fecal α-elastase and the CO program score (p < 0.05). It also leads to a deterioration of gastrointestinal symptoms according to the GSRS questionnaire (p < 0.05). The trophological status of patients with primary osteoarthritis with concomitant exocrine pancreatic insufficiency worsens during anti-inflammatory joint therapy (p < 0.05). Conclusions. Our research indicated a multidirectional effect of NSAIDs in patients with a comorbidity of primary osteoarthritis with exocrine insufficiency of the pancreas.

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Section: Discussionmentioning

confidence: 99%

Different consequences of the treatment of osteoarthritis in gastrointestinal comorbidity with exocrine pancreatic insufficiency

Halabitska¹,

Бабинец²

2021

fmpcr

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“…RAW264.7 cells were seeded in 24-well (1 × 10 5 /well) plates and were pretreated with different concentrations of extracts or compounds for 1 h. The cells were then stimulated by LPS (100 ng/mL) for 18 h. The supernatant was then collected to determine NO production by using Griess reagent (Promega, Madison, WI, United States) according to the manufacturer’s protocol. The levels of TNF-α and IL-6 in the supernatant were quantified by using the corresponding ELISA kit (Cayman, Washtenau County, MI, United States) according to the manufacturer’s instructions ( Lio et al, 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Integrated network pharmacology analysis, molecular docking, LC-MS analysis and bioassays revealed the potential active ingredients and underlying mechanism of Scutellariae radix for COVID-19

Liu

Meng

et al. 2022

Front. Plant Sci.

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“…Macrophages are crucial cells involved in the body’s inflammatory responses. Raw264.7 cells, derived from mouse peritoneal macrophages, are commonly used as a cellular model . Macrophages contribute to the initiation and regulation of inflammatory responses by secreting various proinflammatory mediators and cytokines .…”

Section: Introductionmentioning

confidence: 99%

“…Raw264.7 cells, derived from mouse peritoneal macrophages, are commonly used as a cellular model. 5 Macrophages contribute to the initiation and regulation of inflammatory responses by secreting various proinflammatory mediators and cytokines. 6 They are essential for controlling and eliminating infections, clearing debris and foreign antigens, and promoting tissue repair and wound healing.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effects of e-Cigarette Aerosol Extracts and Tobacco Cigarette Smoke Extracts on RAW264.7 Cells

Zhao,

Han,

Yang

et al. 2023

ACS Omega

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With the advancement of society, electronic cigarettes (e-cigarettes) have gained popularity among a growing number of individuals. While numerous toxicological studies have suggested that e-cigarettes are a safer alternative to traditional cigarettes, there is also a body of literature presenting contrasting findings. This in vitro study aimed to compare the effects of e-cigarettes and tobacco cigarettes (t-cigarettes) on RAW264.7 cells by using four e-cigarette aerosol extracts (ECA) and cigarette smoking extracts (CS) containing different nicotine concentrations. The results revealed that low concentration of nicotine in CS as well as in ECA with grape, watermelon, and cola flavors could promote cell viability. Conversely, high nicotine concentration in CS and ECA with four flavors decreased cell viability. Furthermore, our study demonstrated that CS significantly reduced the phagocytic capability of RAW264.7 cells and increased the levels of inflammatory cytokines (IL-6, TNF-α, and IL-1β) and reactive oxygen species (ROS) compared to ECA. Overall, our findings indicate all four e-cigarettes induced less cytotoxicity to RAW264.7 cells and might be safer than t-cigarettes.

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Nardosinanone N suppresses LPS-induced macrophage activation by modulating the Nrf2 pathway and mPGES-1

Cited by 13 publications

References 65 publications

Different consequences of the treatment of osteoarthritis in gastrointestinal comorbidity with exocrine pancreatic insufficiency

Different consequences of the treatment of osteoarthritis in gastrointestinal comorbidity with exocrine pancreatic insufficiency

Integrated network pharmacology analysis, molecular docking, LC-MS analysis and bioassays revealed the potential active ingredients and underlying mechanism of Scutellariae radix for COVID-19

Evaluation of the Effects of e-Cigarette Aerosol Extracts and Tobacco Cigarette Smoke Extracts on RAW264.7 Cells

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