Naproxen-induced liver injury

Naproxen abatement by thermally activated persulfate in aqueous systems

“…In this study, we have chosen naproxen (NAP) for its presence in sewage treatment plant effluents and drinking water in significant concentrations 17-313 ng L À1 [1]. NAP toxicity was not only reported on bacteria, microcrustaceans and algae, but also on humans [5]. It was also reported that people who ingest trace amounts of NAP for a long time may have a higher risk of having a heart attack or a stroke than people who are not exposed to this medication [6].…”

Comparison of the effects of dexketoprofen trometamol, meloxicam and diclofenac sodium on fibular fracture healing, kidney and liver: An experimental rat model

“…However, in vitro studies have focused on the activity of osteoblasts and have shown that NSAIDs impair the bone turnover, regeneration, and proliferation of osteoblasts [13][14][15][16]. There are limited studies on whether one NSAID shows superiority over another in the bone fracture healing process and with respect to kidney and liver toxicity [1,[17][18][19][20][21]. Keywords: Fracture healing Anti-inflammatory agents Non-steroidal Liver Kidney…”

Cholestatic hepatic injury associated with vismodegib, aspirin, and naproxen use: a case study and review of vismodegib safety

“…According to three international drug‐induced liver injury registries, naproxen is implicated more frequently than aspirin in causing acute liver injury . In seven case studies, cholestasis and hepatitis were associated with naproxen use . However, three systematic reviews suggest that naproxen does not independently increase aminotransferase enzymes or the rate of severe hepatic injury, indicating the likelihood that it was the combination of vismodegib and naproxen that was responsible …”