Naproxen A Reappraisal of its Pharmacology, and Therapeutic Use in Rheumatic Diseases and Pain States

Todd, Peter A.; Clissold, Stephen P.

doi:10.2165/00003495-199040010-00006

Cited by 215 publications

(138 citation statements)

References 222 publications

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“…Naproxen is a non-steroidal anti-inflammatory drug (NSAID) which is used with increasing frequency in the treatment of rheumatic diseases and related painful conditions [3] . Naproxen protein binding in plasma is high and also varied [4] and like other NSAIDs causes gastritis and peptic ulceration after oral administration [5].…”

Section: Introductionmentioning

confidence: 99%

The design of naproxen solid lipid nanoparticles to target skin layers

Âkbari

Saeedi

Morteza‐Semnani

et al. 2016

Colloids and Surfaces B: Biointerfaces

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(2016) The design of naproxen solid lipid nanoparticles to target skin layers. Colloids and Surfaces B: Biointerfaces, This version is available from Sussex Research Online: http://sro.sussex.ac.uk/67745/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Graphical Abstract Highlights  Naproxen solid lipid nanoparticles (Nap-SLN) can successfully be prepared by ultrasonication  Properties of these nanoparticles can be optimized by lipid concentrations  HLB of the surfactants played a crucial effect on properties of solid lipid nanoparticles  Nap-SLN increased the drug concentration in skin layer rather than systemic absorption Accepted Manuscript AbstractThe aim of the current investigation was to produce naproxen solid lipid nanoparticles (Nap-SLNs) by the ultrasonication method to improve its skin permeation and also to investigate the influence of Hydrophilic-lipophilic balance (HLB) changes on nanoparticles properties. The properties of obtained SLNs loaded with naproxen were characterized by photon correlation spectroscopy (PCS), transmission electron microscopy (TEM) and differential scanning calorimetry (DSC). FT-IR was also used to investigate any interaction between naproxen and the excipients used at the molecular level during the preparation of the SLNs. The performance of the formulations was investigated in terms of skin permeation and also the retention of the drug by the skin. It was found that generally, with increasing the lipid concentration, the average particle size and polydispersity index (PDI) ...

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Section: Introductionmentioning

confidence: 99%

The design of naproxen solid lipid nanoparticles to target skin layers

Âkbari

Saeedi

Morteza‐Semnani

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Section: Introductionmentioning

confidence: 99%

“…1 Like other non-steroidal anti-inflammatory drugs, it inhibits the biosyntesis of prostaglandins. 1 The United States Pharmacopeia 2 2003 reports an highperformance liquid chromatography (HPLC) method for the determination of naproxen tablets. Several analytical methods have been reported for the determination of naproxen in pharmaceutical preparations including UV-visible spectrophotomery, 3-5 spectrofluorimetry, 6-8 room temperature phosphorimetry, 9,10 voltametry, 11 high-performance liquid chromatography, 12-14 capillary electrophoresis, 15,16 coulometry 17 and oscilometric titration.…”

mentioning

confidence: 99%

A novel potentiometric naproxenate ion sensor immobilized in a graphite matrix for determination of naproxen in pharmaceuticals

Santini¹,

Oliveira²,

Pezza³

et al. 2006

J. Braz. Chem. Soc.

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As características, o desempenho e a aplicação de um eletrodo do tipo Pt⎪Hg⎪Hg 2 (NAP) 2 ⎪ Graphite, onde NAP=íon naproxenato, são descritas. O eletrodo responde a NAP com sensibilidade de (58,1± 0,9) mV década -1 no intervalo de 5,0 × 10 -5 -1,0 × 10 -2 mol L -1 , a pH 6,0-9,0 e com um limite de detecção de 3,9 × 10 -5 mol L -1 . O eletrodo é de baixo custo e facilmente construído, apresenta um rápido tempo de resposta (10-35 s) e pode ser usado por um período de seis meses sem qualquer divergência considerável nos potenciais. O sensor supracitado mostrou boa seletividade para naproxeno na presença de várias substâncias, tais como carboxilatos e ânions inorgânicos, sendo aplicado na análise direta de naproxeno em medicamentos (comprimidos) via método da adição de padrão. Os resultados analíticos obtidos com o eletrodo proposto estão em boa concordância com aqueles obtidos pelo procedimento preconizado na Farmacopéia Americana.The characteristics, performance, and application of an electrode, namely, Pt⎪Hg⎪Hg 2 (NAP) 2 ⎪ Graphite, where NAP stands for naproxenate ion, are described. This electrode responds to NAP with sensivity of (58.1± 0.9) mV decade -1 over the range 5.0 × 10 -5 -1.0 × 10 -2 mol L -1 at pH 6.0-9.0 and a detection limit of 3.9 × 10 -5 mol L -1 . The electrode is easily constructed at a relatively low cost with fast response time (within 10-35 s) and can be used for a period of 6 months without any considerable divergence in potentials. The proposed sensor displayed good selectivity for naproxen in the presence of several substances, especially concerning carboxylate and inorganic anions. It was used for the direct assay of naproxen in commercial tablets by means of the standard additions method. The analytical results obtained by using this electrode are in good agreement with those given by the United States Pharmacopeia procedure.Keywords: naproxenate-sensitive electrode, potentiometry, pharmaceutical formulations Introduction Naproxen [(+)-2-(6-metoxy-2naphthyl)propionic acid], is a non-steroidal anti-inflammatory drug that also presents analgesic and antipyretic properties often preferred to acetylsalicylic acid because of its better absortion following oral administration and fewer adverse effects.Naproxen is extensively used in the treatment of many diseases like rheumatoid arthrits, degenerative joint disease, ankylosing spondylits, acute gout and primary dismenorrea. 1 Like other non-steroidal anti-inflammatory drugs, it inhibits the biosyntesis of prostaglandins. 1 The United States Pharmacopeia 2 2003 reports an highperformance liquid chromatography (HPLC) method for the determination of naproxen tablets. Several analytical methods have been reported for the determination of naproxen in pharmaceutical preparations including UV-visible spectrophotomery, 3-5 spectrofluorimetry, 6-8 room temperature phosphorimetry, 9,10 voltametry, 11 high-performance liquid chromatography, 12-14 capillary electrophoresis, 15,16 coulometry 17 and oscilometric titration. 18 However, most of these techniq...

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“…In fact the naproxen concentration gained in human aqueous (approximately 370 ng/ml = 1.5 M) is able to inhibit COX activity by at least 50% in selected human and animal tissue. 5 Preoperative good pupil dilatation is generally achieved using a combination of adrenergic agonists and cholinergic antagonists. Usually adrenaline is also used intracamerally as an irrigating solution to help maintain mydriasis during surgery.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 Naproxen sodium is a well-known NSAID with established anti-inflammatory activity. 5 As an ophthalmic solution, it is able to decrease aqueous levels of proteins, polymorphonuclear leukocytes and PGE 2 following experimentally induced inflammation in rabbits. 6,7 In addition, topical sodium naproxen successfully maintains mydriasis induced by atropine following paracentesis in the rabbit eye.…”

Section: Introductionmentioning

confidence: 99%

Topical naproxen sodium for inhibition of miosis during cataract surgery. Prospective, randomized clinical trials

Papa

Russo

et al. 2002

Eye

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Results In both studies the pupillary diameter decreased during surgery within each treatment group in a statistically significant manner (P Ͻ 0.001). Naproxen was more effective than placebo (P Ͻ 0.01) and as effective as diclofenac in controlling pupil diameter regression during cataract. Mean concentration level of naproxen in the aqueous humor was 372.3 ng/ml. Conclusions Naproxen sodium ophthalmic solution penetrates the cornea and it is effective in maintaining intraoperative mydriasis.

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Naproxen A Reappraisal of its Pharmacology, and Therapeutic Use in Rheumatic Diseases and Pain States

Cited by 215 publications

References 222 publications

The design of naproxen solid lipid nanoparticles to target skin layers

The design of naproxen solid lipid nanoparticles to target skin layers

A novel potentiometric naproxenate ion sensor immobilized in a graphite matrix for determination of naproxen in pharmaceuticals

Topical naproxen sodium for inhibition of miosis during cataract surgery. Prospective, randomized clinical trials

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