Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation

Lin, Kuei Li; Su, Jun-Ming; Chien, Ching Ming; Tseng, Chih Hua; Chen, Yeh Long; Chang, Long; Lin, Shinne Ren

doi:10.1016/j.tiv.2009.09.002

Cited by 35 publications

(20 citation statements)

References 44 publications

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“…Generally, the ERK signaling cascade is involved in cell proliferation and differentiation (Johnson and Lapadat, 2002). However, ERK signaling pathways are also associated with stress responses and may have proapoptotic roles in cells undergoing apoptosis (Lin et al, 2009;Wada and Penninger, 2004;Wang et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Wogonin Induces Apoptosis by Activation of ERK and p38 MAPKs Signaling Pathways and Generation of Reactive Oxygen Species in Human Breast Cancer Cells

Kim

2011

Molecules and Cells

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Wogonin is a one of the bioactive compounds of Scutellaria baicalensi Georgi which has been shown to have antiinflammatory, anticancer, antiviral and neuroprotective effects. However, the underlying mechanisms by which wogonin induces apoptosis in cancer cells still remain speculative. Here we investigated the potential activation of MAPKs and generation of reactive oxygen species (ROS) by wogonin on MCF-7 human breast cancer cells. These results showed that wogonin induced mitochondria and death-receptor-mediated apoptotic cell death, which was characterized by activation of several caspases, induction of PARP cleavage, change of antiapoptotic/proapoptotic Bcl-2 family member ratios and cleavage of Bid. We also found that generation of ROS was an important mediator in wogonin-induced apoptosis. Further investigation revealed that wogonin activated ERK and p38 MAPKs, which was inhibited by N-acetyl cysteine (NAC), a ROS scavenger, indicating that wogonin-induced ROS are associated with MAPKs activation. These data demonstrate that wogonin may be a novel anticancer agent for treatment of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Wogonin Induces Apoptosis by Activation of ERK and p38 MAPKs Signaling Pathways and Generation of Reactive Oxygen Species in Human Breast Cancer Cells

Kim

2011

Molecules and Cells

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“…[26][27][28] In this study, we demonstrate that IFNα upregulates the expression of DRs and downregulates the expression of survivin, consistent with the effects of IFNα on TRAIL-induced apoptosis in human hepatoma cells. 18 However, since recent studies have shown that ERK is linked to the expression of death receptors and survivin in a variety of experimental systems, 24,25 we further investigated the role of the MAPK/ERK pathway in mediating the synergistic effect of IFNα and TRAIL. It has been reported that the RAS-MEK-ERK1/2 signaling pathway sensitizes human colon cancer cells to TRAIL-induced apoptosis by upregulating DR4 and DR5.…”

Section: Methodsmentioning

confidence: 99%

“…Recent studies have shown that expression of DRs and survivin is regulated by the MAPK/ERK pathway. 24,25 This led us to investigate whether IFNα could activate the MAPK/ERK pathway, resulting in changes in DR and survivin expression, and thereby mediating amplification of TRAIL-induced death signaling. Our data indicate that IFNα upregulates the level of phosphorylated ERK (p-ERK) in a time-dependent manner (Fig.…”

Section: O N O T D I S T R I B U T Ementioning

confidence: 99%

Interferon-α sensitizes human gastric cancer cells to TRAIL-induced apoptosis via activation of the c-CBL-dependent MAPK/ERK pathway

Qu¹,

Zhao²,

Teng³

et al. 2011

Cancer Biology & Therapy

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“…Redox-triggered ERK1/2 phosphorylation could induce both intrinsic and extrinsic apoptotic pathways (43,44), and autophagy can be positively regulated by ERK1/2 (21). Various drugs induced autophagies were correlated with a persistent activation or cytoplasmic sequestration of ERK1/2 (21,45).…”

Section: Discussionmentioning

confidence: 98%

Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Cancer Cell Growth by S Phase Arrest, Apoptosis, and Autophagy via Redox-Dependent ERK1/2 Pathway

She

Wang

et al. 2015

Cancer Prevention Research

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Cancer is still the major cause of death across the world. Regular approaches cannot effectively solve the emerging problems, including drug/radiation resistance, side effects, and therapeutic ineffectiveness. Natural dietary supplements have shown effectiveness in the prevention and treatment of cancer. Sarsaparilla (Smilax Glabra Rhizome) has growth-inhibitory effects on several cancer cell lines in vitro and in vivo, with little toxicity on normal cells. However, the mechanism underlying its function remains elusive. In the present study, we examined the anticancer activity of the supernatant of the water-soluble extract (SW) from sarsaparilla. Liquid chromatography/mass spectrometry-ion trap-time-of-flight (LC/MS-IT-TOF) analysis identified flavonoids, alkaloids, and phenylpropanoids as the major bioactive components of SW. SW was shown to markedly inhibit the growth of a broad spectrum of cancer cell lines in the in vitro and in vivo assays. S phase arrest, autophagy, or/and apoptosis were partly responsible for SW-induced growth inhibition. Results of microarray analysis and validation by quantitative RT-PCR indicated the involvement of oxidative stress and the MAPK1 pathway in SW-treated cells. We further found that SW destroyed intracellular-reduced glutathione/oxidized glutathione (GSH/GSSG) balance, and supplement with N-acetylcysteine (NAC) or glutathione (GSH) significantly antagonized SW-induced S phase arrest, apoptosis, and autophagy. In addition, SW-induced GSH/GSSG imbalance activated the ERK1/2 pathway, which contributed to SW-induced S phase arrest, apoptosis, autophagy, and resultant growth-inhibitory effect. Together, our results provide a molecular basis for sarsaparilla as an anticancer agent. Cancer Prev Res; 8(5); 464-74.Ó2015 AACR.

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Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation

Cited by 35 publications

References 44 publications

Wogonin Induces Apoptosis by Activation of ERK and p38 MAPKs Signaling Pathways and Generation of Reactive Oxygen Species in Human Breast Cancer Cells

Wogonin Induces Apoptosis by Activation of ERK and p38 MAPKs Signaling Pathways and Generation of Reactive Oxygen Species in Human Breast Cancer Cells

Interferon-α sensitizes human gastric cancer cells to TRAIL-induced apoptosis via activation of the c-CBL-dependent MAPK/ERK pathway

Sarsaparilla (Smilax Glabra Rhizome) Extract Inhibits Cancer Cell Growth by S Phase Arrest, Apoptosis, and Autophagy via Redox-Dependent ERK1/2 Pathway

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