Nanozymes and nanoflower: Physiochemical properties, mechanism and biomedical applications

Perwez, Mohammad; Lau, Sie Yon; Hussain, Danish; Anboo, Shamini; Arshad, Mohammad Yusof; Thakur, Pankaj

doi:10.1016/j.colsurfb.2023.113241

Cited by 13 publications

(6 citation statements)

References 298 publications

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“…In addition, shape modification (e.g., nanoflowers) of the nanozymes can endow them with a high density of spikes, good optical properties, and larger surface-to-volume ratios, which can enhance the catalytic activity, adsorption, and loading capacity of the nanozymes. 51 Surface modification. By modifying the surface of nanozymes with specific functional groups or targeting ligands, their catalytic activity and specificity for cancer cells can be increased.…”

Section: Strategies For Improving the Catalytic Activity And Specific...mentioning

confidence: 99%

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Nanozyme-enhanced ferroptosis for cancer treatment

Ming,

Huang,

Huang

et al. 2024

Mater. Chem. Front.

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Section: Strategies For Improving the Catalytic Activity And Specific...mentioning

confidence: 99%

“…, nanoflowers) of the nanozymes can endow them with a high density of spikes, good optical properties, and larger surface-to-volume ratios, which can enhance the catalytic activity, adsorption, and loading capacity of the nanozymes. 51…”

Section: Design and Synthesis Of Nanozymesmentioning

confidence: 99%

Nanozyme-enhanced ferroptosis for cancer treatment

Ming,

Huang,

Huang

et al. 2024

Mater. Chem. Front.

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“…These materials exhibit enzyme-like activities, enhanced catalytic activities, low costs, ease of preparation, stability, and biocompatibility, as outlined in their research. [17] For example; Lu and coworkers employed an organic-inorganic hybrid method to produce a hybrid nanoflower of phytic acid (PA)modified α-Glucosidase (α-Glu) with Cu 3 (PO 4 ) 2 • 3H 2 O. They optimized the enzymatic reaction conditions, including pH value and temperature, resulting in improved enzymatic activity across a wide pH range and at higher temperatures compared to the free enzyme.…”

Section: Introduction β-Glucosidasesmentioning

confidence: 99%

“…Perwez and coworkers; in their study summarizing organic‐inorganic hybrid materials, highlighted the advantages of the synthesized structures in mimicking natural enzyme functions. These materials exhibit enzyme‐like activities, enhanced catalytic activities, low costs, ease of preparation, stability, and biocompatibility, as outlined in their research [17] . For example; Lu and coworkers employed an organic‐inorganic hybrid method to produce a hybrid nanoflower of phytic acid (PA)‐modified α‐Glucosidase (α‐Glu) with Cu 3 (PO 4 ) 2 ⋅ 3H 2 O.…”

Section: Introductionmentioning

confidence: 99%

Influence of Metal Ions and Organic Solutions on Activity and Stability of Beta‐Glucosidase Nanoflowers

Altinkaynak,

Samsa,

Ekremoglu

et al. 2024

ChemistrySelect

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Abstractβ‐Glucosidase, a pivotal enzyme in the synthesis of various glycosides with wide applications in industries such as food, cosmetics, beverages, bioenergy, nutraceuticals, pharmaceuticals, and detergents, undergoes immobilization to enhance its utility in industrial processes and improve enzymatic properties. In this study, the conventional hybrid nanoflower synthesis method was used for β‐glucosidase‐inorganic hybrid nanoflowers. Following a comprehensive pH and temperature scanning of the nanoflowers, the influence of metallic ions and various organic solvents on hybrid nanoflowers to enhance the activity and stability of the biocatalyst were investigated. The optimal morphology for β‐Glu/NFs was determined to be 0.01 mg/mL. To obtain the optimum activity conditions, we explored pH values ranging from 3 to 8 and temperatures between 30 and 80 °C. Both the free form and β‐Glu/NFs exhibited higher activity in acidic conditions, with a significant decrease in activity observed at pH 7 and 8. β‐Glu/NFs demonstrated superior activity compared to the free enzyme in the presence of metal ions, exhibiting a remarkable 3.6‐fold increase in activity in chloroform, and approximately 2.8 and 2.7 times increase in benzene and glycerol, respectively. Moreover, it displayed over a 2‐fold increase in activity in methanol, ethanol, isopropanol, n‐butanol, acetone, and DMSO.

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“…14 The emergence of nanozymes provides a new idea for the design and development of nanosystems. 15 This is a new interdisciplinary field combining nanotechnology and biomedicine. 16,17 Scientists have developed various nanomaterials with enzyme-like activity, such as Fe 3 O 4 nanoparticles, Au nanoparticles, and MnO 2 nanoparticles, which possess the catalytic abilities like catalase (CAT) and superoxide dismutase (SOD).…”

Section: Introductionmentioning

confidence: 99%

Application of Multifunctional Nanozymes in Tumor Therapy

Shao,

Wang,

et al. 2024

ACS Omega

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Tumors are one of the main diseases threatening human life and health. The emergence of nanotechnology in recent years has introduced a novel therapeutic avenue for addressing tumors. Through the amalgamation of nanotechnology's inherent attributes with those of natural enzymes, nanozymes have demonstrated the ability to initiate catalytic reactions, modulate the biological microenvironment, and facilitate the adoption of multifaceted therapeutic approaches, thereby exhibiting considerable promise in the realm of cancer treatment. In this Review, the application of nanozymes in chemodynamic therapy, radiotherapy, photodynamic therapy, photothermal therapy, and starvation therapy are summarized. Moreover, a detailed discussion regarding the mechanism of conferring physiotherapeutic functionality upon catalytic nanosystems is provided. It is posited that this innovative catalytic treatment holds significant potential to play a crucial role within the domain of nanomedicine.

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Nanozymes and nanoflower: Physiochemical properties, mechanism and biomedical applications

Cited by 13 publications

References 298 publications

Nanozyme-enhanced ferroptosis for cancer treatment

Nanozyme-enhanced ferroptosis for cancer treatment

Influence of Metal Ions and Organic Solutions on Activity and Stability of Beta‐Glucosidase Nanoflowers

Application of Multifunctional Nanozymes in Tumor Therapy

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