Nanozyme-enhanced ferroptosis for cancer treatment

Ming, Yue; Huang, Mingshu; Huang, Yisheng; Liu, Danqing; Sun, Min; Jia, Bo; Du, Jianzhong

doi:10.1039/d3qm01202f

Cited by 4 publications

(1 citation statement)

References 153 publications

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“…20–23 Strategies aimed at enhancing ferroptosis induction represent a promising approach to augment the effectiveness of chemotherapy, particularly by exploiting non-apoptotic cell death pathways associated with reactive oxygen species accumulation and lipid peroxidation. 24,25 Research into ferroptosis inducers has seen a significant surge, with numerous methods for inducing ferroptosis in cancer treatment extensively investigated. These methods include the utilization of small molecules such as erastin, sorafenib (SRF), and sulfasalazine (SAS), or shMTHFD2 and shGPX4 plasmids those target related genes.…”

Section: Introductionmentioning

confidence: 99%

Strategic design and development of a siderophore mimic: pioneering anticancer therapy via ROS generation and ferroptosis

Panwar,

Lye,

Musib

et al. 2024

Dalton Trans.

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Section: Introductionmentioning

confidence: 99%

Strategic design and development of a siderophore mimic: pioneering anticancer therapy via ROS generation and ferroptosis

Panwar,

Lye,

Musib

et al. 2024

Dalton Trans.

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A Ferroptosis‐Inhibitive Polypeptosome for Synergistic Management of Acute Kidney Injury Through Antioxidation and Iron Binding

Liu,

Zhang,

Fan

et al. 2024

Adv Funct Materials

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Acute kidney injury (AKI) is a critical condition with a wide range of triggers that cause heavy burden on public health. Despite its high incidence and mortality, the treatment of AKI still highly relies on hemodialysis, which is costly and usually accompanied by severe complications. Therefore, development of new therapeutic targets and methods for AKI is urgently needed. Herein, a ferroptosis‐targeting strategy for AKI treatment by rationally designed ferroptosis‐inhibitive polypeptide‐based polymersomes (polypeptosomes, FIPs) is proposed. Such FIPs are self‐assembled from poly(glutamic acid)‐block‐poly(methionine‐stat‐tyrosine) [PGA9‐b‐P(Met8‐stat‐PTyr13)]. The ferroptosis‐inhibition function of the FIPs arises from the rationally‐selected amino acid composition: P(Met‐stat‐Tyr) endows the FIPs with a high scavenging efficiency of over 90% toward different reactive oxygen species (ROS); while the glutamate and tyrosine residues, as well as the amide groups, can bind iron ions, thus blocking iron overload and lipid peroxide in cells. In vivo experiments confirm that the FIPs can effectively alleviate oxidative stress, inhibit ferroptosis, and restore kidney functions. Transcriptome sequencing further reveals the therapeutic mechanisms of FIPs. Overall, such polypeptosomes capable of blocking multiple pathways of ferroptosis open a new avenue for AKI treatment and provide fresh insights into the development of generalized therapies for inflammation.

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Mutually reinforced cancer treatment based on phototherapy combined with ferroptosis

Chen,

Gan,

Tian

et al. 2024

Chemical Engineering Journal

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Nanozyme-enhanced ferroptosis for cancer treatment

Abstract: Ferroptosis is a programmed, iron-dependent, oxidative cell death that was discovered recently. It is usually accompanied by iron accumulation and lipid peroxidation during the cell death process. Ferroptosis-inducing factors affect...

Cited by 4 publications

References 153 publications

Strategic design and development of a siderophore mimic: pioneering anticancer therapy via ROS generation and ferroptosis

Strategic design and development of a siderophore mimic: pioneering anticancer therapy via ROS generation and ferroptosis

A Ferroptosis‐Inhibitive Polypeptosome for Synergistic Management of Acute Kidney Injury Through Antioxidation and Iron Binding

Mutually reinforced cancer treatment based on phototherapy combined with ferroptosis

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