Nanozyme‐Based Stretchable Hydrogel of Low Hysteresis with Antibacterial and Antioxidant Dual Functions for Closely Fitting and Wound Healing in Movable Parts

Abstract

Wound healing in movable parts including joints and neck remains a critical challenge due to frequent motions and poor flexibility of dressing which may lead to mismatching of mechanical properties and poor fitting between dressings and wounds, thus increasing the risk of bacterial infection and inflammation. Herein, through the copolymerization of N-isopropylacrylamide, acrylamide, and acryloyl Pluronic 127 (PF127-DA), and functionalization by molybdenum disulfide-polydopamine nanozyme (MP), a new type of stretchable, adhesive, and low hysteretic MP composite hydrogel (MPH) with antibacterial and antioxidant dual functions for closely fitting and wound healing in movable parts is designed. The excellent mechanical properties (stretching about 616%, hysteresis about 0.17) and adhesiveness (about 3.25 kPa) of MPH make it fast to match the motions of the movable parts, close to fit with wound resisting bacterial invasion, and effective to avoid secondary dressing fixation. Furthermore, the dual functions of antibacterial derived from photothermal properties and antioxidant derived from intrinsic enzyme-like activity can eliminate the infection (exposing to 808 nm irradiation, the killing ratios for Staphylococcus aureus and Escherichia coli are 99.1% and 93.9%), reduce oxidative stress, improve wound microenvironment, and promote wound healing.

Anti-oxidant anti-inflammatory and antibacterial tannin-crosslinked citrate-based mussel-inspired bioadhesives facilitate scarless wound healing

“…Excessive accumulation of ROS in infected wounds can overwhelm the native antioxidant defense system, strengthen the inflammatory reaction, and thus delay wound healing [ 7 , 8 ] and cause scar formation [ [9] , [10] , [11] , [12] ], resulting in skin dysfunction and adverse cosmetic appearance [ 13 ]. ROS-scavenging biomaterials including polyphenols [ 14 , 15 ], nanozymes [ 16 , 17 ], and others, exhibit enhanced therapeutic effects via augmentation of malfunctioning or depleted native antioxidant mechanisms, indicating their utility in the resolution of delayed wound closure and scarless wound healing. The development of a multifunctional therapeutic material system combining antimicrobial capacity, ROS scavenging, and promotion of skin regeneration is thus highly desirable.…”

Highly Resilient Dual-Crosslinked Hydrogel Adhesives Based on a Dopamine-Modified Crosslinker

“…The AA-TD hydrogel demonstrated superior mechanical performance compared to that of previously reported hydrogel adhesives for skin wound healing around joints. The AA-TD exhibit hydrogel exhibits more than 3-fold tissue adhesion (71.4 kPa) and excellent maintenance of tissue adhesion in a moist environment (over 10 kPa after 48 h), 29,48 and negligible hysteresis loop changes under a large strain rate (below 200% strain). 33,49 Moreover, the hydrogel exhibits higher tissue adhesion than commercially available fibrin and cyanoacrylate glues.…”

A Study on Dual-Response Composite Hydrogels Based on Oriented Nanocellulose

“…L929 cells with a cell density of 4 × 10 4 /mL were seeded into a 48-well plate and incubated for 24 h. Various concentrations of the cross-linked CN+HAMA hydrogels scaffold sheets with a diameter of 8 mm and a thickness of 2 mm were added to the cell medium in different wells. After coculture for 1, 3, and 7 days, cell counting kit-8 (CCK-8) solution was added to each well and incubated for 2 h. Subsequently, the reaction solution transferred to another 96-well plate, the optical density (OD) of the solution was measured by a spectrophotometer at 450 nm[ 38 ].…”