Nanovesicles for Nanomedicine: Theory and Practices

Wadhwa, Sheetu; Garg, Varun; Gulati, Monica; Kapoor, Bhupinder; Singh, Sachin Kumar; Mittal, Neeraj

doi:10.1007/978-1-4939-9516-5_1

Cited by 17 publications

(12 citation statements)

References 54 publications

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“…Nanovesicular systems (also known as nanovesicles) can typically be distinguished by their unilamellar structures, which have become up-and-coming drug delivery and targeting systems. 198 The original vesicles are conventional liposomes before they are adapted into niosomes, transfersomes, and ethosomes, named after their characteristics and compositions. 199 They can be assembled per need of their membrane components, and the type of the drug (hydrophobic or hydrophilic), 199 which are useful for topical delivery of psoriasis.…”

Section: Types and Properties Of Lipid-based Nanoparticles For Psoria...mentioning

confidence: 99%

Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects

et al. 2021

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Section: Types and Properties Of Lipid-based Nanoparticles For Psoria...mentioning

confidence: 99%

Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects

et al. 2021

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“…Liposomes can differ in their design based on their preparation method (extrusion techniques, reverse phase evaporation method, sonication, dehydration method, and more recently, microfluidics) [ 26 , 27 ] and their structural parameters in terms of size, charge and lamellarity (unilamellar, multilamellar and oligolamellar vesicles) [ 6 ]. They can also differ based on their function, application and composition.…”

Section: Application Of Liposomes In Drug Deliverymentioning

confidence: 99%

The Role of Cryoprotective Agents in Liposome Stabilization and Preservation

Boafo

Magar

Ekpo

et al. 2022

IJMS

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To improve liposomes’ usage as drug delivery vehicles, cryoprotectants can be utilized to prevent constituent leakage and liposome instability. Cryoprotective agents (CPAs) or cryoprotectants can protect liposomes from the mechanical stress of ice by vitrifying at a specific temperature, which forms a glassy matrix. The majority of studies on cryoprotectants demonstrate that as the concentration of the cryoprotectant is increased, the liposomal stability improves, resulting in decreased aggregation. The effectiveness of CPAs in maintaining liposome stability in the aqueous state essentially depends on a complex interaction between protectants and bilayer composition. Furthermore, different types of CPAs have distinct effective mechanisms of action; therefore, the combination of several cryoprotectants may be beneficial and novel attributed to the synergistic actions of the CPAs. In this review, we discuss the use of liposomes as drug delivery vehicles, phospholipid–CPA interactions, their thermotropic behavior during freezing, types of CPA and their mechanism for preventing leakage of drugs from liposomes.

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“…The evolution of natural-lipid-based nanovesicles that possess structural resemblances to biological chylomicrons (CMs) are now well recognized as potential candidates for organ-targeted drug delivery [ 14 ], along with other liposomes [ 15 ]. They have the advantages of being biologically compatible drug nanocarriers.…”

Section: Introductionmentioning

confidence: 99%

Inclusion of a Phytomedicinal Flavonoid in Biocompatible Surface-Modified Chylomicron Mimic Nanovesicles with Improved Oral Bioavailability and Virucidal Activity: Molecular Modeling and Pharmacodynamic Studies

et al. 2022

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Morin hydrate (MH) is a widely-used Asian phytomedicinal flavonoid with a wide range of reported therapeutic activities. However, MH has limited oral bioavailability due to its low aqueous solubility and intestinal permeability, which in turn hinders its potential antiviral activity. The study reported herein was designed to encapsulate MH in polyethyleneglycolated (PEGylated) chylomicrons (PCMs) and to boost its antiviral activity and biological availability for oral administration using a rat experimental model. The PEGylated edge activator combined with the conventional components of chylomicrons (CMs) amplify the transport of the drug across the intestine and its circulation period, hence its therapeutic impact. The implementation of variables in the in vitro characterization of the vesicles was investigated. Using Design Expert® software, a 24 factorial design was conducted, and the resulting PCM formulations were fabricated utilizing a thin-film hydration technique. The efficacy of the formulations was assessed according to their zeta potential (ZP), entrapment efficiency percentage (EE%), amount of drug released after 8 h (Q8h), and particle size (PS) data. Formulation F9, which was deemed to be the optimal formula, used compritol as the lipidic core together in defined amounts with phosphatidylcholine (PC) and Brij52. Computer-aided studies revealed that MH alone in a suspension had both diminished intestinal permeability and absorption, but was enhanced when loaded in PCMs. This was affirmed by the superiority of formulation F9 results in ex vivo permeation and pharmacokinetic studies. Furthermore, formulation F9 had a superior safety profile and antiviral activity over a pure MH suspension. Molecular-docking studies revealed the capability of MH to inhibit MERS-CoV 3CLpro, the enzyme shown to exhibit a crucial role in viral replication. Additionally, F9 suppressed both MERS-CoV-induced histopathological alteration in lung tissue and resulting oxidative and inflammatory biomarkers. Collectively, the results reported herein affirmed the potential of PCMs as nanocarriers for the effective oral administration of MH as an antiviral.

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Nanovesicles for Nanomedicine: Theory and Practices

Cited by 17 publications

References 54 publications

Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects

Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects

The Role of Cryoprotective Agents in Liposome Stabilization and Preservation

Inclusion of a Phytomedicinal Flavonoid in Biocompatible Surface-Modified Chylomicron Mimic Nanovesicles with Improved Oral Bioavailability and Virucidal Activity: Molecular Modeling and Pharmacodynamic Studies

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