Nanotubular Oxide Layers and Hydroxyapatite Coatings on Porous Titanium Alloy Ti13Nb13Zr

Abstract

The surface condition of an implant has a significant impact on response occurring at the implant-biosystem border. The knowledge of physical-chemical and biological processes allows for targeted modification of biomaterials to induce a specified response of a tissue. The present research was aimed at development of technology composing of obtaining the nanotube oxide layers on a porous titanium alloy Ti13Nb13Zr, followed by the deposition of phosphate coating. The porous substrate (porosity about 50%) was prepared by a selective laser melting of the Ti13Nb13Zr powder with the SLM Realizer 100 equipment. The nanotubular oxide layers were fabricated by electrochemical oxidation in H3PO4 + 0.3% HF mixture for 30 min. at a constant voltage of 20V. The calcium phosphate coatings were formed by the electrochemically assisted deposition (ECAD). The presence of nanotubular oxide layers with their internal diameters ranging from 30 to 100 nm was observed by SEM (JEOL JSM-7600F). The nanotubes have dimensions that facilitated the deposition of hydroxyapatite.

Influence of Laser Modification on the Surface Character of Biomaterials: Titanium and Its Alloys—A Review

“…The Pourbaix diagram shows that titanium is a metal that passivates very quickly [86]. The natural, very good corrosion resistance of titanium and its alloys is indicated [87][88][89][90][91]. Additionally, the corrosion behavior is influenced by the presence of β-stabilizing alloying elements and their role in the stability and thickness of the passive layer formed [92].…”

Synthesis and Characterization of Nanostructured Oxide Layers on Ti-Nb-Zr-Ta and Ti-Nb-Zr-Fe Biomedical Alloys

“…It is expected that organized nanotubular complex oxides will form during the α phase, whereas a combination of nanotubes and nanopores will grow during the two-phase (α + β) component [41]. Several studies have reported on the surface modification of ternary Ti-30Nb-xZr [42]; Ti-35Nb-5Zr, Ti-35Nb-10Zr, and Ti-35Nb-15Zr [43]; Ti-35Nb-2Zr and Ti-35Nb-4Zr [44]; and Ti-13Nb-13Zr [45,46]. This has brought valuable knowledge on important process parameter choices.…”

Fabrication of TiO2 microspikes for highly efficient intracellular delivery by pulse laser-assisted photoporation

“…Besides the metal substrate, nanostructures can also be formed using anodization on Ti alloy substrates, such as Ti-6Al-7Nb, 8,21 Ni-Ti, 22,23 Ti-6Al-4V, 7 Ti13Nb13Zr 24, 25 and Ti15Mo. 26 Among the many nanostructured oxide materials, TiO 2 -based nanostructures have signicant characteristics, such as improved ion-exchangeable ability, photocatalytic properties, environmental safety, and nontoxicity. However, the formation of TiO 2 microspikes on titanium substrate by electrochemical anodization process and their biomedical applications, such as drug delivery or intracellular delivery, have not yet been studied.…”