Nanotube-mediated efficiency of cisplatin anticancer therapy

Werengowska-Ciećwierz, Karolina; Wiśniewski, Marek; Terzyk, Artur P.; Gurtowska, Natalia; Olkowska, Joanna; Kloskowski, Tomasz; Drewa, Tomasz; Kiełkowska, Urszula; Drużyński, Sebastian

doi:10.1016/j.carbon.2013.12.060

Cited by 24 publications

(25 citation statements)

References 57 publications

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“…The results of recent in vitro and in vivo studies [195][196][197][198] suggest that described novel DDS should be more effective and successful against cancer cells in comparison to traditional chemotherapy. Application of nanovehicles in targeted active treatment seems to be very promising direction in current material science and medicine.…”

Section: Discussionmentioning

confidence: 99%

The Chemistry of Bioconjugation in Nanoparticles-Based Drug Delivery System

Werengowska-Ciećwierz

Wiśniewski

Terzyk

et al. 2015

Advances in Condensed Matter Physics

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Nanomedicine is, generally, the application of nanotechnology to medicine. The term nanomedicine includes monitoring, construction of novel drug delivery systems, and any possible future applications of nanotechnology and nanovaccinology. In this review, the most important ligand-nanocarrier and drug-nanocarrier bioconjugations are described. The detailed characterizations of covalently formed bonds between targeted ligand and nanocarrier, including amide, thioether, disulfide, acetyl-hydrazone and polycyclic groups, are described. Also, the coupling of small elements and heteroatoms in the form of R-X-R the “click chemistry” groups is shown. Physical adsorption and chemical bonding of drug to nanocarrier surface involving drug on the internal or external surfaces of nanocarriers are described throughout possibility of the formation of the above-mentioned functionalities. Moreover, the most popular nanostructures (liposomes, micelles, polymeric nanoparticles, dendrimers, carbon nanotubes, and nanohorns) are characterized as nanocarriers. Building of modern drug carrier is a new method which could be effectively applied in targeted anticancer therapy.

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Section: Discussionmentioning

confidence: 99%

The Chemistry of Bioconjugation in Nanoparticles-Based Drug Delivery System

Werengowska-Ciećwierz

Wiśniewski

Terzyk

et al. 2015

Advances in Condensed Matter Physics

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“…Z-contrast scanning transmission electron microscopy (STEM) is one of the powerful tools for imaging individual heavy atoms in materials science applications and, most recently, this technique is used for imaging the distribution of platinum-based drug molecules attached to SWCNTs [105,106]. STEM operates similarly as the normal SEM, by using a focused beam of electrons that scanned across a thin sample while some desired signal is then collected by a detector to form image at the atomic level [107].…”

Section: Imaging Microscopies: Sem Tem Stem Afm and Stmmentioning

confidence: 99%

“…STEM operates similarly as the normal SEM, by using a focused beam of electrons that scanned across a thin sample while some desired signal is then collected by a detector to form image at the atomic level [107]. It is an ideal technique for quantifying image intensities and determining the number of heavy metal-based drugs attached to nanotubes or other low-Z nanocarriers [105,106].…”

Section: Imaging Microscopies: Sem Tem Stem Afm and Stmmentioning

confidence: 99%

“…In view of this, a group of researchers used hydrothermally oxidized SWCNTs as delivery vehicle for the loading of platinum (Pt)-based drug prepared differently using water or dimethylformamide (DMF) as solvents [106]. They observed that the drug is rapidly delivered into the cells for system prepared using DMF as solvent, especially for the first 10 h of treatment.…”

Section: Cisplatin (Cis)mentioning

confidence: 99%

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A Review on Characterizations and Biocompatibility of Functionalized Carbon Nanotubes in Drug Delivery Design

Tan

Arulselvan

Fakurazi

et al. 2014

Journal of Nanomaterials

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The revolutionary development of functionalized carbon nanotubes (f-CNTs) for applications in nanomedicine has emerged as one of the most interesting fields, which has increased exponentially in recent years. This is due to their appealing physical and chemical properties, as well as their unique architecture. After a brief introduction on the physicochemical properties of carbon nanotubes (CNTs), we described several functionalization methods for the surface modification of CNTs, with the aim to facilitate their solubility in physiological aqueous environment. This review focuses on recent advances in drug delivery design based onf-CNTs with an emphasis on the determination of various parameters involved and characterization methods used in order to achieve higher therapeutic efficacy of targeted drug delivery. In particular, we will highlight a variety of different analytical techniques which can be used to characterize the elemental composition, chemical structure, and functional groups introduced onto the CNTs after surface modification. We also review the current progress of availablein vitrobiocompatibility assays based onf-CNTs and then discuss their toxicological profile and biodistribution for advanced drug delivery.

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“…Next challenge [ 17 ] is related to the controllable surface chemistry of nanomaterials. By the procedure of hydrothermal oxidation [ 18 – 20 ], we are able to add controllable number of oxygen groups on the surface of nanotubes; however, we can control mainly concentration of those groups. In this way, using the hydrothermal treatment procedure, being so-called “green chemistry” method, we also pick up challenge 3 [ 17 ]—we avoid organic solvents during modifications—and in this way, we reduce the unintended impurities.…”

Section: Introduction and The Aims Of The Studymentioning

confidence: 99%

Conscious Changes of Carbon Nanotubes Cytotoxicity by Manipulation with Selected Nanofactors

Werengowska-Ciećwierz

Wiśniewski

Terzyk

et al. 2015

Appl Biochem Biotechnol

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We discuss eight major challenges in the field of carbon nanomaterial toxicity. Generally, we pick up some of them, and the most important challenge is searching of the qualitative relationships between nanofactors and cytotoxicity. This is important since it can provide the possibility of conscious changes of carbon nanotubes cytotoxicity by manipulation with selected nanofactors. Therefore, the toxicity of a series of gradually oxidized carbon nanotubes is studied. We show, for the first time, that toxicity of those materials depends strongly on the ratio of acidic to basic group concentration—the higher is this ratio value, the more toxic are nanotubes. In this way, by changing this ratio, one can change toxicity. This correlation is more evident after ultrasonication, and it is connected with the accessibility of charged groups for interactions with proteins. Toxicity also depends on the ability of nanotubes for protein adsorption. We suggest that the changes in the protein composition of medium, especially lack of important growth factors, inhibit cell proliferation.Electronic supplementary materialThe online version of this article (doi:10.1007/s12010-015-1607-1) contains supplementary material, which is available to authorized users.

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Nanotube-mediated efficiency of cisplatin anticancer therapy

Cited by 24 publications

References 57 publications

The Chemistry of Bioconjugation in Nanoparticles-Based Drug Delivery System

The Chemistry of Bioconjugation in Nanoparticles-Based Drug Delivery System

A Review on Characterizations and Biocompatibility of Functionalized Carbon Nanotubes in Drug Delivery Design

Conscious Changes of Carbon Nanotubes Cytotoxicity by Manipulation with Selected Nanofactors

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