Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2

Li, Huimin; Guo, Huilin; Lei, Chang; Liu, Li; Xu, Liqin; Feng, Yaping; Jin, Ke; Fang, Wei; Song, Hao; Xu, Chun; Yu, Chengzhong; Long, Xing

doi:10.1002/adma.201904535

Cited by 56 publications

(45 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nowadays, nanomaterials have been widely applied in the field of bone regeneration, [ 21–24 ] since they possess several outstanding advantages, such as large surface area‐to‐volume ratio, higher reactivity, and easy surface modification. [ 25 ] Carbon dots (CDs), a new type of fluorescent nanomaterial, [ 26,27 ] display unique properties of small size, facile preparation, low cost, good biocompatibility, and excellent optical properties.…”

Section: Introductionmentioning

confidence: 99%

Metformin Carbon Dots for Promoting Periodontal Bone Regeneration via Activation of ERK/AMPK Pathway

Ren

Hao

Wang

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

The osteogenic potential of mesenchymal stem cells (MSCs) is severely impaired under persistent inflammation of periodontitis. A highly efficient way to promote or rescue osteogenic potential of MSCs under inflammation remains an unmet goal. Herein, metformin carbon dots (MCDs) with excellent biocompatibility are prepared from metformin hydrochloride and citric acid via a hydrothermal method. The MCDs can more effectively enhance the alkaline phosphatase (ALP) activity, calcium deposition nodules formation, expression of osteogenic genes and proteins in rat bone marrow mesenchymal stem cells (rBMSCs) than metformin under both inflammatory and normal conditions. Moreover, a novel pathway of extracellular signal‐regulated kinases (ERK)/AMP‐activated protein kinase (AMPK) signaling is involved in the MCDs‐induced osteogenesis. In periodontitis rats, MCDs can effectively regenerate the lost alveolar bone, but not the metformin. Taken together, MCDs can be the promising candidate nanomaterial for periodontitis treatment. This work may provide a new pharmacological target of ERK/AMPK pathway for treating bone loss and also give additional insights into developing nanodrugs from the numerous medications.

show abstract

Section: Introductionmentioning

confidence: 99%

Metformin Carbon Dots for Promoting Periodontal Bone Regeneration via Activation of ERK/AMPK Pathway

Ren

Hao

Wang

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…For a long time, as a representative of inorganic aerogels, silica aerogels have been widely studied and applied because of their low cost and good structure and properties [7,8]. In the field of biomedicine, previous studies have shown the diffusion mechanism of drugs in silica aerogels [9,10], and that silica nanoparticle-loaded drugs have had good targeted therapeutic effects on diseases [11,12]. In recent years, considering the degradability of materials, scientists have turned their attention to the development of natural polymers [13].…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization, and In Vitro Evaluation of Resveratrol-Loaded Cellulose Aerogel

Qin

Zhao

et al. 2020

Materials

View full text Add to dashboard Cite

Resveratrol is a natural active ingredient found in plants, which is a polyphenolic compound and has a variety of pharmaceutical uses. Resveratrol-loaded TEMPO-oxidized cellulose aerogel (RLTA) was prepared using a freeze-drying method, employing high speed homogenization followed by rapid freezing with liquid nitrogen. RLTAs were designed at varying drug–cellulose aerogel ratios (1:2, 2:3, 3:2, and 2:1). It could be seen via scanning electron microscopy (SEM) that Res integrated into TEMPO-oxidized cellulose (TC) at different ratios, which changed its aggregation state and turned it into a short rod-like structure. Fourier transform infrared (FTIR) spectra confirmed that the RLTAs had the characteristic peaks of TC and Res. In addition, X-ray diffraction (XRD) demonstrated that the grain size of RLTA was obviously smaller than that of pure Res. RLTAs also had excellent stability in both simulated gastric fluid and phosphate buffer solution. The drug release rate was initially completed within 5 h under a loading rate of 30.7 wt%. The results of an MTT assay showed the low toxicity and good biocompatibility of the RLTAs. TC aerogel could be a promising drug carrier that may be widely used in designing and preparing novel biomedicine.

show abstract

“…In this way, the therapeutic system based on nanoparticles with the capabilities of regulating the OA microenvironment can intelligently enter the targeted cells and thereby efficiently suppress inflammation and delay the progression of OA. Li et al have demonstrated that polyethyleneimine-modified mesoporous silica nanospheres can successfully bring hyaluronan synthase type 2 into synoviocytes to synthesize endogenous HA with high molecular weight and downregulate the synovial inflammatory mediators in the OA microenvironment, hence promoting the self-repairing mechanism and putting forward a totally different method for OA management [ 258 ]. Chen et al designed a novel MMP-13/pH-responsive and cartilage-targeting ferritin nanocages encapsulating hydroxychloroquine for OA imaging and therapy, which can smartly monitor the overproduced MMP-13 in OA and release hydroxychloroquine induced by weak acid.…”

Section: Chronic Inflammation-associated Diseases and Therapiesmentioning

confidence: 99%

The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials

et al. 2021

View full text Add to dashboard Cite

Tissue regeneration is an active multiplex process involving the dynamic inflammatory microenvironment. Under a normal physiological framework, inflammation is necessary for the systematic immunity including tissue repair and regeneration as well as returning to homeostasis. Inflammatory cellular response and metabolic mechanisms play key roles in the well-orchestrated tissue regeneration. If this response is dysregulated, it becomes chronic, which in turn causes progressive fibrosis, improper repair, and autoimmune disorders, ultimately leading to organ failure and death. Therefore, understanding of the complex inflammatory multiple player responses and their cellular metabolisms facilitates the latest insights and brings novel therapeutic methods for early diseases and modern health challenges. This review discusses the recent advances in molecular interactions of immune cells, controlled shift of pro- to anti-inflammation, reparative inflammatory metabolisms in tissue regeneration, controlling of an unfavorable microenvironment, dysregulated inflammatory diseases, and emerging therapeutic strategies including the use of biomaterials, which expand therapeutic views and briefly denote important gaps that are still prevailing.

show abstract

Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2

Cited by 56 publications

References 37 publications

Metformin Carbon Dots for Promoting Periodontal Bone Regeneration via Activation of ERK/AMPK Pathway

Metformin Carbon Dots for Promoting Periodontal Bone Regeneration via Activation of ERK/AMPK Pathway

Preparation, Characterization, and In Vitro Evaluation of Resveratrol-Loaded Cellulose Aerogel

The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials

Contact Info

Product

Resources

About