Nanotheranostics: Metal–Organic‐Framework‐Derived Carbon Nanostructures for Site‐Specific Dual‐Modality Photothermal/Photodynamic Thrombus Therapy (Adv. Sci. 17/2019)

Zhang, Fengrong; Liu, Yuehong; Lei, Jiani; Wang, Shunhao; Ji, Xunming; Liu, Huiyu; Yang, Qi

doi:10.1002/advs.201970106

Cited by 14 publications

(24 citation statements)

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“…Our previous studies have shown that the generated ROS can disrupt phospholipids such as platelet factor 3. [ 28 ] Moreover, ROS could disrupt the fibrin skeleton, as assessed by fluorescein isothiocyanate (FITC)‐labeled fibrin clots assay. In Figure 4d, amount of collapsed skeleton and fragments were distinguished after incubating fibrin with nanoparticles and US irradiation.…”

Section: Methodsmentioning

confidence: 99%

Surface Wettability of Nanoparticle Modulated Sonothrombolysis

Zhang

Pan

et al. 2021

Advanced Materials

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Sonodynamic therapy (SDT) is a non‐invasive and highly penetrating treatment strategy under ultrasound irradiation. However, uncertainty in the mechanism of SDT has seriously hindered its future clinical application. Here, the mechanism of SDT enhanced by the wettability of nanoparticles is investigated. Nanoparticles can adsorb and stabilize nanobubbles in liquid, thus enhancing SDT efficiency. The stability of the nanobubbles is positively correlated with the desorption energy of the nanoparticles, which is determined by the wettability of the nanoparticles. This conclusion is verified for mesoporous silica and polystyrene nanoparticles and it is found that nanoparticles with a water contact angle of about 90° possess the largest desorption energy. To further apply this conclusion, thrombus models are constructed on rats and the experimental results demonstrate that nanoparticles with the largest desorption energy have the highest thrombolytic efficiency. It is believed that these findings will help to better understand the SDT mechanism and guide new strategies for rational design of nanoparticles adopted in SDT.

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Section: Methodsmentioning

confidence: 99%

Surface Wettability of Nanoparticle Modulated Sonothrombolysis

Zhang

Pan

et al. 2021

Advanced Materials

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“…The artificial thrombus formed by fresh blood agglomeration with the help of calcium chloride and thrombin has been utilized for intuitive evaluation of thrombolysis ability in vitro. [ 25,45 ] Capillary thrombus and tail bleeding assay are also important in in vitro models for evaluating theranostic systems. [ 46 ] Thus, the active exploration of newly‐fashioned thrombus‐related disease murine models, such as mimetic thrombus detachment and migration, is another important avenue to push the clinical translation of fundamental research.…”

Section: Mouse Thrombosis and Thrombus‐related Disease Modelsmentioning

confidence: 99%

Near‐Infrared Fluorophores for Thrombosis Diagnosis and Therapy

Sun

Hettie

Zhu

2021

Advanced Therapeutics

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Thrombosis is an adverse physiological event wherein the resulting thrombus and thrombus‐induced diseases collectively result in high morbidity and mortality rates. Currently, nano‐medicines that incorporate fluorophores emitting in the near‐infrared‐I (NIR‐I, 700–900 nm) spectral region have been adopted to afford thrombosis theranostics. However, several unsolved problems such as limited penetration depth and image quality severely impede further applications of such nano‐medicine systems. Fortunately, the ability to incorporate fluorophores emitting in the NIR‐II (1000–1700 nm) window into nano‐medicine systems can unambiguously identify biological processes with high signal‐to‐noise, deep tissue penetration depth, and high image resolution. Considering the inherently favorable properties of NIR‐II fluorophores, it is believed that they have enormous potential to quickly become incorporated into nano‐medicine systems for thrombosis theranostics. In this review, i) the development of NIR fluorescence as an imaging modality and fluorescent agents is discussed; ii) the recent development of NIR‐I fluorophore‐based nano‐medicine systems for thrombosis theranostics is comprehensively summarized; iii) the state‐of‐the‐art NIR‐II fluorophores that are designed for the specific purpose of affording thrombotic diagnosis is highlighted; iv) possible forward avenues for the use of NIR‐II fluorophores toward thrombosis diagnosis and therapy are speculated; and v) the potential for their clinical translation is discussed.

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“…[ 13,16,114–117 ] Dual‐photothermal/photodynamic thrombolysis has also been reported using nanostructured porphyrin. [ 118 ]…”

Section: Stimuli‐mediated Thrombolysismentioning

confidence: 99%

“…One of the major criticisms of NIR‐induced photothermal thrombolysis is the risk of secondary embolism to small blood vessels by larger clot fragments. [ 118 ]…”

Section: Stimuli‐mediated Thrombolysismentioning

confidence: 99%

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Smart Delivery of Plasminogen Activators for Efficient Thrombolysis; Recent Trends and Future Perspectives

Refaat

Rosal

Palasubramaniam

et al. 2021

Advanced Therapeutics

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Fibrinolytic drugs have been successfully used to manage acute thrombotic and thromboembolic conditions. However, their narrow administration time window, rapid clearance, and possible inactivation limit their efficient and wider application. Most importantly, they present a substantial risk of fatal bleeding complications, which are a major cause of mortality and morbidity. Improving the therapeutic outcomes of pharmacological thrombolysis, including alleviating associated side effects, is an urgent challenge. In this context, nano‐drug delivery systems have attracted major interest. State‐of‐the‐art nanodelivery systems have achieved reduced immunogenicity and a significant prolongation of the biological half‐life of drugs, the latter allowing their application as boli instead of infusions. Recent research focuses on theranostic systems capable of image‐guided thrombolysis, clot targeting strategies, and stimuli‐responsive systems. The latter are designed so that an external or internal stimulus triggers the drug release, offering unique spatiotemporal control over the treatment and potentially minimizing side effects. In this review, the authors discuss the different nanodelivery platforms and focus on stimuli‐responsive systems, highlighting their therapeutic advantages and the challenges for their clinical translation.

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Nanotheranostics: Metal–Organic‐Framework‐Derived Carbon Nanostructures for Site‐Specific Dual‐Modality Photothermal/Photodynamic Thrombus Therapy (Adv. Sci. 17/2019)

Cited by 14 publications

References 0 publications

Surface Wettability of Nanoparticle Modulated Sonothrombolysis

Surface Wettability of Nanoparticle Modulated Sonothrombolysis

Near‐Infrared Fluorophores for Thrombosis Diagnosis and Therapy

Smart Delivery of Plasminogen Activators for Efficient Thrombolysis; Recent Trends and Future Perspectives

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