“…Analogous to natural enzymes, nanozymes possess up to four different catalytic types, including oxidoreductase-, hydrolase-, lyase-, and isomerase-like nanozymes . Among them, oxidoreductase-like nanozymes are a large family that was the earliest discovered and most fully developed, accounting for more than 96% of the known nanozymes, e.g., oxidase (OXD)-, peroxidase (POD)-, catalase (CAT)-, and superoxide dismutase (SOD)-like nanozymes. , To date, the catalytic types and activities of nanozymes have been precisely modulated through a series of methods: for example, size engineering, valence engineering, surface modification, crystal surface engineering, and defect engineering . Specifically, size engineering tunes the number of active sites on the surface of nanomaterials per unit mass, thus upregulating or downregulating the catalytic activity of nanozymes.…”