Nanotheranostics-based Management of Head and Neck Cancer

Chavda, Vivek P.; Balar, Pankti C.; Patel, Srushti B.

doi:10.7150/ntno.81724

Cited by 14 publications

(7 citation statements)

References 56 publications

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“…NPs made of silver and gold have enormous potential as theranostic agents. They have the benefits of simplicity in synthesis, bioconjugation, and surface changes that make AuNPs more biocompatible and less cytotoxic . With the same multimodal imaging capabilities and application flexibility as MNPs, AuNPs provide a greater range of therapeutic and diagnostic utility for treating cancer .…”

Section: Plasmonic Theranosticsmentioning

confidence: 99%

“…They have the benefits of simplicity in synthesis, bioconjugation, and surface changes that make AuNPs more biocompatible and less cytotoxic. 142 With the same multimodal imaging capabilities and application flexibility as MNPs, AuNPs provide a greater range of therapeutic and diagnostic utility for treating cancer. 132 SERS nanoantennas can be conjugated with the FDA-approved antibody cetuximab, inhibiting cancer via epidermal growth factor receptor deactivation.…”

Section: Plasmonic Theranosticsmentioning

confidence: 99%

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Conjugated Nanoparticles for Solid Tumor Theranostics: Unraveling the Interplay of Known and Unknown Factors

Chavda,

Balar,

Nalla

et al. 2023

ACS Omega

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Cancer diagnoses have been increasing worldwide, and solid tumors are among the leading contributors to patient mortality, creating an enormous burden on the global healthcare system. Cancer is responsible for around 10.3 million deaths worldwide. Solid tumors are one of the most prevalent cancers observed in recent times. On the other hand, early diagnosis is a significant challenge that could save a person's life. Treatment with existing methods has pitfalls that limit the successful elimination of the disorder. Though nanoparticle-based imaging and therapeutics have shown a significant impact in healthcare, current methodologies for solid tumor treatment are insufficient. There are multiple complications associated with the diagnosis and management of solid tumors as well. Recently, surface-conjugated nanoparticles such as lipid nanoparticles, metallic nanoparticles, and quantum dots have shown positive results in solid tumor diagnostics and therapeutics in preclinical models. Other nanotheranostic material platforms such as plasmonic theranostics, magnetotheranostics, hybrid nanotheranostics, and graphene theranostics have also been explored. These nanoparticle theranostics ensure the appropriate targeting of tumors along with selective delivery of cargos (both imaging and therapeutic probes) without affecting the surrounding healthy tissues. Though they have multiple applications, nanoparticles still possess numerous limitations that need to be addressed in order to be fully utilized in the clinic. In this review, we outline the importance of materials and design strategies used to engineer nanoparticles in the treatment and diagnosis of solid tumors and how effectively each method overcomes the drawbacks of the current techniques. We also highlight the gaps in each material platform and how design considerations can address their limitations in future research directions.

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Section: Plasmonic Theranosticsmentioning

confidence: 99%

Section: Plasmonic Theranosticsmentioning

confidence: 99%

Conjugated Nanoparticles for Solid Tumor Theranostics: Unraveling the Interplay of Known and Unknown Factors

Chavda,

Balar,

Nalla

et al. 2023

ACS Omega

Self Cite

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“…International Publisher the tumor heterogeneity to achieve a better prognosis [8]. And nanotheranostics can play a pivotal role in the stratification of the patient on basis of the therapeutic efficacy of the nanomedicine [9].…”

Section: Ivyspringmentioning

confidence: 99%

“…Early and precise diagnosis plays a pivotal role in determining the outcome of the treatment and for these various biomarkers and bio-imaging modalities are utilized [8,12,13]. Certain organic, inorganic and hybrid based nanoparticulate materials are developed that can aid in diagnostic as well as therapeutic outcomes.…”

Section: Ivyspringmentioning

confidence: 99%

Current status of Cancer Nanotheranostics: Emerging strategies for cancer management

Chavda¹,

Khadela²,

Shah³

et al. 2023

Nanotheranostics

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Cancer diagnosis and management have been a slow-evolving area in medical science. Conventional therapies have by far proved to have various limitations. Also, the concept of immunotherapy which was thought to revolutionize the management of cancer has presented its range of drawbacks. To overcome these limitations nanoparticulate-derived diagnostic and therapeutic strategies are emerging. These nanomaterials are to be explored as they serve as a prospect for cancer theranostics. Nanoparticles have a significant yet unclear role in screening as well as therapy of cancer. However, nanogels and Photodynamic therapy is one such approach to be developed in cancer theranostics. Photoactive cancer theranostics is a vivid area that might prove to help manage cancer. Also, the utilization of the quantum dots as a diagnostic tool and to selectively kill cancer cells, especially in CNS tumors. Additionally, the redox-sensitive micelles targeting the tumor microenvironment of the cancer are also an important theranostic tool. This review focuses on exploring various agents that are currently being studied or can further be studied as cancer theranostics.

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“…Analogous to natural enzymes, nanozymes possess up to four different catalytic types, including oxidoreductase-, hydrolase-, lyase-, and isomerase-like nanozymes . Among them, oxidoreductase-like nanozymes are a large family that was the earliest discovered and most fully developed, accounting for more than 96% of the known nanozymes, e.g., oxidase (OXD)-, peroxidase (POD)-, catalase (CAT)-, and superoxide dismutase (SOD)-like nanozymes. , To date, the catalytic types and activities of nanozymes have been precisely modulated through a series of methods: for example, size engineering, valence engineering, surface modification, crystal surface engineering, and defect engineering . Specifically, size engineering tunes the number of active sites on the surface of nanomaterials per unit mass, thus upregulating or downregulating the catalytic activity of nanozymes.…”

Section: Introductionmentioning

confidence: 99%

Rational Design Strategies for Nanozymes

Chen

Gao

et al. 2023

ACS Nano

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Nanozymes constitute an emerging class of nanomaterials with enzyme-like characteristics. Over the past 15 years, more than 1200 nanozymes have been developed, and they have demonstrated promising potentials in broad applications. With the diversification and complexity of its applications, traditional empirical and trial-and-error design strategies no longer meet the requirements for efficient nanozyme design. Thanks to the rapid development of computational chemistry and artificial intelligence technologies, first-principles methods and machine-learning algorithms are gradually being adopted as a more efficient and easier means to assist nanozyme design. This review focuses on the potential elementary reaction mechanisms in the rational design of nanozymes, including peroxidase (POD)-, oxidase (OXD)-, catalase (CAT)-, superoxide dismutase (SOD)-, and hydrolase (HYL)-like nanozymes. The activity descriptors are introduced, with the aim of providing further guidelines for nanozyme active material screening. The computing- and data-driven approaches are thoroughly reviewed to give a proposal on how to proceed with the next-generation paradigm rational design. At the end of this review, personal perspectives on the prospects and challenges of the rational design of nanozymes are put forward, hoping to promote the further development of nanozymes toward superior application performance in the future.

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Nanotheranostics-based Management of Head and Neck Cancer

Cited by 14 publications

References 56 publications

Conjugated Nanoparticles for Solid Tumor Theranostics: Unraveling the Interplay of Known and Unknown Factors

Conjugated Nanoparticles for Solid Tumor Theranostics: Unraveling the Interplay of Known and Unknown Factors

Current status of Cancer Nanotheranostics: Emerging strategies for cancer management

Rational Design Strategies for Nanozymes

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