Nanotechnology reinforced neutrophil-based therapeutic strategies for inflammatory diseases therapy

Wu, Jiahe; Ma, Teng; Zhu, Manhua; Huang, Tianchen; Zhang, Bo; Gao, Jian; Lin, Nengming

doi:10.1016/j.nantod.2022.101577

Cited by 20 publications

(14 citation statements)

References 165 publications

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“…It has been widely recognized that neutrophils participate in tumor progression and evolution. − Peripheral neutrophils will be attracted by inflammation context in tumor sites and anchor with inflamed vascular endothelial cells through the ligand–receptor reaction between adhesion-associated proteins on the neutrophil membrane and corresponding receptors on the endothelium, like LFA-1 and intercellular cell adhesion molecular-1 (ICAM-1), and be recruited to tumor sites eventually …”

Section: Resultsmentioning

confidence: 99%

“…As the most abundant white blood cells and indispensable constituents of innate immune homeostasis, neutrophils are the first cells to respond to inflammatory reactions and are deeply involved in tumorigenesis, progression, and prognosis. , Tumor cells attract neutrophils in peripheral circulation through secreted inflammatory cytokines. Attracted neutrophils migrate along the chemotactic gradient of inflammatory factors and extravasate across the vascular barrier by virtue of the interaction between cell surface adhesion molecules to arrive at the chronic inflammation context surrounding the tumor .…”

Section: Introductionmentioning

confidence: 99%

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A Pluripotential Neutrophil-Mimic Nanovehicle Modulates Immune Microenvironment with Targeted Drug Delivery for Augmented Antitumor Chemotherapy

Wu,

Ma,

Zhu

et al. 2024

ACS Nano

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The limited therapeutic outcomes and severe systemic toxicity of chemotherapy remain major challenges to the current clinical antitumor therapeutic regimen. Tumor-targeted drug delivery that diminishes the undifferentiated systemic distribution is a practical solution to ameliorating systemic toxicity. However, the tumor adaptive immune microenvironment still poses a great threat that compromises the therapeutic efficacy of chemotherapy by promoting the tolerance of the tumor cells. Herein, a pluripotential neutrophil-mimic nanovehicle (Neutrosome(L)) composed of an activated neutrophil membrane-incorporated liposome is proposed to modulate the immune microenvironment and synergize antitumor chemotherapy. The prominent tumor targeting capability inherited from activated neutrophils and the improved tumor penetration ability of Neutrosome(L) enable considerable drug accumulation in tumor tissues (more than sixfold that of free drug). Importantly, Neutrosome(L) can modulate the immune microenvironment by restricting neutrophil infiltration in tumor tissue, which may be attributed to the neutralization of inflammatory cytokines, thus potentiating antitumor chemotherapy. As a consequence, the treatment of cisplatin-loaded Neutrosome(L) performs prominent tumor suppression effects, reduces systemic drug toxicity, and prolongs the survival period of tumor-bearing mice. The pluripotential neutrophil-mimic nanovehicle proposed in this study can not only enhance the tumor accumulation of chemotherapeutics but also modulate the immune microenvironment, providing a compendious strategy for augmented antitumor chemotherapy.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Pluripotential Neutrophil-Mimic Nanovehicle Modulates Immune Microenvironment with Targeted Drug Delivery for Augmented Antitumor Chemotherapy

Wu,

Ma,

Zhu

et al. 2024

ACS Nano

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“…Otherwise, their persistent existence can worsen inflammation and delay wound healing. Therefore, controlling the behavior of neutrophils is essential for regulating the inflammation, 67 which can be regarded as a cellular target for immunomodulation. In this regard, one strategy is to reduce their activation, adhesion, and infiltration.…”

Section: Cellular Targets For Immunomodulationmentioning

confidence: 99%

Immunomodulatory hydrogels for skin wound healing: cellular targets and design strategy

He,

Cen,

Tian

2024

J. Mater. Chem. B

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“…Immune cells can combat bacterial infection through various pathways. 147 Therefore, regulating the immune microenvironment around the infection is a feasible approach to participate in antibiofilm.…”

Section: Nanocomposites For Regulating Infection Microenvironmentmentioning

confidence: 99%

Recent nanotechnology-based strategies for interfering with the life cycle of bacterial biofilms

Zhang

Lin

2023

Biomater. Sci.

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Nanotechnology reinforced neutrophil-based therapeutic strategies for inflammatory diseases therapy

Cited by 20 publications

References 165 publications

A Pluripotential Neutrophil-Mimic Nanovehicle Modulates Immune Microenvironment with Targeted Drug Delivery for Augmented Antitumor Chemotherapy

A Pluripotential Neutrophil-Mimic Nanovehicle Modulates Immune Microenvironment with Targeted Drug Delivery for Augmented Antitumor Chemotherapy

Immunomodulatory hydrogels for skin wound healing: cellular targets and design strategy

Recent nanotechnology-based strategies for interfering with the life cycle of bacterial biofilms

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