Nanotechnology-Ocular Devices for Glaucoma Treatment: A Literature Review

Cardigos, Joana; Ferreira, Quirina; Crisóstomo, Sara; Moura-Coelho, Nuno; Cunha, João Paulo; Pinto, Luís Abegão; Ferreira, Joana Tavares

doi:10.1080/02713683.2018.1536218

Cited by 17 publications

(10 citation statements)

References 56 publications

(66 reference statements)

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“…The breakthrough for the development of organic devices is to develop smart devices able to replace silicon semiconductor components. The trend is to learn with biological systems [89,90,91,92,93,94,95]. To develop functional devices, it is important to understand how biological machines work and mimic their mechanisms.…”

Section: Perspectivesmentioning

confidence: 99%

Bottom-Up Self-Assembled Supramolecular Structures Built by STM at the Solid/Liquid Interface

et al. 2019

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One of the lines of research on organic devices is focused on their miniaturization to obtain denser and faster electronic circuits. The challenge is to build devices adding atom by atom or molecule by molecule until the desired structures are achieved. To do this job, techniques able to see and manipulate matter at this scale are needed. Scanning tunneling microscopy (STM) has been the selected technique by scientists to develop smart and functional unimolecular devices. This review article compiles the latest developments in this field giving examples of supramolecular systems monitored and fabricated at the molecular scale by bottom-up approaches using STM at the solid/liquid interface.

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Section: Perspectivesmentioning

confidence: 99%

Bottom-Up Self-Assembled Supramolecular Structures Built by STM at the Solid/Liquid Interface

et al. 2019

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“…The nano delivery systems can make use of nanoparticles (NPs) [43], nanoemulsions [44], nanodiamonds (NDs) [45], nanocrystals [46], liposomes [47], dendrimers [48], cyclodextrins [49], and other devices [50] together with contact lenses (Figure 4). The physicochemical properties (hydrophobicity, length, and stability), target tissue and the administration route determine which device and materials to use.…”

Section: Advancements Of Nanomedicine In Glaucomamentioning

confidence: 99%

“…Devices are mostly used in the drainage of glaucoma when trabeculectomy and IOP-lowering medication prove inefficient [50,94]. The mentioned devices give a different route for the aqueous humor to the collection plate beneath the conjunctiva from the anterior section of the eye.…”

Section: Diagnostic and Therapeutic Glaucoma Nanodevicesmentioning

confidence: 99%

Promising Approach in the Treatment of Glaucoma Using Nanotechnology and Nanomedicine-Based Systems

et al. 2019

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Glaucoma is considered a leading cause of blindness with the human eye being one of the body’s most delicate organs. Ocular diseases encompass diverse diseases affecting the anterior and posterior ocular sections, respectively. The human eye’s peculiar and exclusive anatomy and physiology continue to pose a significant obstacle to researchers and pharmacologists in the provision of efficient drug delivery. Though several traditional invasive and noninvasive eye therapies exist, including implants, eye drops, and injections, there are still significant complications that arise which may either be their low bioavailability or the grave ocular adverse effects experienced thereafter. On the other hand, new nanoscience technology and nanotechnology serve as a novel approach in ocular disease treatment. In order to interact specifically with ocular tissues and overcome ocular challenges, numerous active molecules have been modified to react with nanocarriers. In the general population of glaucoma patients, disease growth and advancement cannot be contained by decreasing intraocular pressure (IOP), hence a spiking in future research for novel drug delivery systems and target therapeutics. This review focuses on nanotechnology and its therapeutic and diagnostic prospects in ophthalmology, specifically glaucoma. Nanotechnology and nanomedicine history, the human eye anatomy, research frontiers in nanomedicine and nanotechnology, its imaging modal quality, diagnostic and surgical approach, and its possible application in glaucoma will all be further explored below. Particular focus will be on the efficiency and safety of this new therapy and its advances.

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“…The breakthrough for the development of organic devices is to develop smart devices able to replace all silicon semiconductor components. The trend is to learn with biological systems [79][80][81][82][83][84][85].…”

Section: Future Perspectivementioning

confidence: 99%

Bottom-Up Self-Assembled Supramolecular Structures Built by STM at Solid/Liquid Interface

Ferreira¹,

Delfino²,

Morgado³

et al. 2018

Preprint

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The development of organic devices has been focused in their miniaturization in order to obtain denser and faster electronic circuits. The challenge is to build the devices adding atom by atom or molecule by molecule until the desired structure is achieved. To do this job, techniques able to see and manipulate matter at this scale are needed. Scanning tunneling microscopy has been the selected technique by scientists to develop smart and functional unimolecular devices. This review article compiles the latest developments in this field giving examples of supramolecular systems monitored and fabricated at molecular scale by bottom-up approaches using STM at solid/liquid interface.

show abstract

Nanotechnology-Ocular Devices for Glaucoma Treatment: A Literature Review

Cited by 17 publications

References 56 publications

Bottom-Up Self-Assembled Supramolecular Structures Built by STM at the Solid/Liquid Interface

Bottom-Up Self-Assembled Supramolecular Structures Built by STM at the Solid/Liquid Interface

Promising Approach in the Treatment of Glaucoma Using Nanotechnology and Nanomedicine-Based Systems

Bottom-Up Self-Assembled Supramolecular Structures Built by STM at Solid/Liquid Interface

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