Nanotechnology in Ophthalmology

Petrović, Nenad; Petrovic, M.; Srećković, Sunčica; Jovanović, Svetlana; Todorović, Dušan; Vulović, Tatjana Šarenac

doi:10.1007/978-3-319-56979-6_11

Cited by 7 publications

(8 citation statements)

References 106 publications

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“…In order to overcome ocular therapies limitations, the development of novel delivery systems is constantly under study. In this way, nanotechnology has been exploited in ocular therapy with overall good results 58,81,97 . Nanomedicine is the use of nanotechnology in medicine.…”

Section: Nanoparticulate Systems For Bd Delivery Intended For Ocular mentioning

confidence: 99%

“…In this way, nanotechnology has been exploited in ocular therapy with overall good results. 58,81,97 Nanomedicine is the use of nanotechnology in medicine. It is the science and technology used in the design and evaluation of systems at nanometric scale, made up of at least the active principle or biologically active molecule and the system itself, which generates a special applicability related to diagnosis, monitoring, treating, or prevention of a disease at the expense of its physical, chemical, and biological properties.…”

Section: Nanoparticul Ate Sys Tems For B D Delivery Intended For O Cul Ar Ang I Og Ene S Is Tre Atmentmentioning

confidence: 99%

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Biological drug therapy for ocular angiogenesis: Anti‐VEGF agents and novel strategies based on nanotechnology

Formica

Alfonso

Palma

2021

Pharmacology Res & Perspec

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Currently, biological drug therapy for ocular angiogenesis treatment is based on the administration of anti‐VEGF agents via intravitreal route. The molecules approved with this purpose for ocular use include pegaptanib, ranibizumab, and aflibercept, whereas bevacizumab is commonly off‐label used in the clinical practice. The schedule dosage involves repeated intravitreal injections of anti‐VEGF agents to achieve and maintain effective concentrations in retina and choroids, which are administrated as solutions form. In this review article, we describe the features of different anti‐VEGF agents, major challenges for their ocular delivery and the nanoparticles in development as delivery system of them. In this way, several polymeric and lipid nanoparticles are explored to load anti‐VEGF agents with the aim of achieving sustained drug release and thus, minimize the number of intravitreal injections required. The main challenges were focused in the loading the molecules that maintain their bioactivity after their release from nanoparticulate system, followed the evaluation of them through studies of formulation stability, pharmacokinetic, and efficacy in in vitro and in vivo models. The analysis was based on the information published in peer‐reviewed published papers relevant to anti‐VEGF treatments and nanoparticles developed as ocular anti‐VEGF delivery system.

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Section: Nanoparticulate Systems For Bd Delivery Intended For Ocular mentioning

confidence: 99%

Section: Nanoparticul Ate Sys Tems For B D Delivery Intended For O Cul Ar Ang I Og Ene S Is Tre Atmentmentioning

confidence: 99%

Biological drug therapy for ocular angiogenesis: Anti‐VEGF agents and novel strategies based on nanotechnology

Formica

Alfonso

Palma

2021

Pharmacology Res & Perspec

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“…During the past decades, nanotechnology-based applications have provided a new perspective on treatment of ocular diseases via increasing drug bioavailability, providing controllable release of therapeutic compounds, decreasing eye irritation, and enhancing the performance of treatment by providing up to 100% drug permeability to both anterior and posterior segments of the eye [ 23 ]. Several nanotechnology-based treatment options have been developed for ocular diseases which can be counted as nanoparticles, micelles, nanoemulsions, nanofibers, nanobubbles, liposomes, dendrimers, nano-capsules, etc.…”

Section: Topical Nano-formulations For Ocular Drug Deliverymentioning

confidence: 99%

Application of Convergent Science and Technology toward Ocular Disease Treatment

et al. 2023

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Eyes are one of the main critical organs of the body that provide our brain with the most information about the surrounding environment. Disturbance in the activity of this informational organ, resulting from different ocular diseases, could affect the quality of life, so finding appropriate methods for treating ocular disease has attracted lots of attention. This is especially due to the ineffectiveness of the conventional therapeutic method to deliver drugs into the interior parts of the eye, and the also presence of barriers such as tear film, blood-ocular, and blood-retina barriers. Recently, some novel techniques, such as different types of contact lenses, micro and nanoneedles and in situ gels, have been introduced which can overcome the previously mentioned barriers. These novel techniques could enhance the bioavailability of therapeutic components inside the eyes, deliver them to the posterior side of the eyes, release them in a controlled manner, and reduce the side effects of previous methods (such as eye drops). Accordingly, this review paper aims to summarize some of the evidence on the effectiveness of these new techniques for treating ocular disease, their preclinical and clinical progression, current limitations, and future perspectives.

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“…2.5.6. Ophthalmology Some applications of nanotechnology to ophthalmology are explained in [125]. These applications include the treatment of oxidative stress, measurement of intraocular pressure, theragnostics the use of nanoparticles to treat choroidal new vessels, prevent scarring after glaucoma surgery, and treat retinal degenerative disease with gene therapy; prosthetics; and regenerative nanomedicine [125].…”

Section: Fluorescence Imagingmentioning

confidence: 99%

A Brief Review on Challenges in Design and Development of Nanorobots for Medical Applications

Giri¹,

Maddahi²,

Zareinia³

2023

Preprint

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<p>Robotics is a rapidly growing field, and the innovative idea to scale down the size of robots to the nanometer level has paved a new way of treating human health. Nanorobots have become the focus of many researchers aiming to explore their many potential applications in medicine. This paper focuses on manufacturing techniques involved in the fabrication of nanorobots and their associated challenges in terms of design architecture, sensors, actuators, powering, navigation, data transmission, followed by challenges in applications. In addition, an overview of various nanorobotic systems addresses different architectures of a nanorobot. Moreover, multiple medical applications, such as oncology, drug delivery, and surgery, are reviewed and summarized.</p>

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Nanotechnology in Ophthalmology

Cited by 7 publications

References 106 publications

Biological drug therapy for ocular angiogenesis: Anti‐VEGF agents and novel strategies based on nanotechnology

Biological drug therapy for ocular angiogenesis: Anti‐VEGF agents and novel strategies based on nanotechnology

Application of Convergent Science and Technology toward Ocular Disease Treatment

A Brief Review on Challenges in Design and Development of Nanorobots for Medical Applications

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