Nanotechnology in medicine: Leads from Ayurveda

Sharma, Rohit; Prajapati, PK

doi:10.4103/0975-7406.171730

Cited by 58 publications

(27 citation statements)

References 10 publications

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“…The dominant ingredient is Amla , a citrus fruit that is a highly renowned and potent botanical in Ayurveda. The main ingredients of CP, along with their botanical identities, key active biomolecules and specific therapeutic roles, are detailed in Figure 1 and Table 1 [12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55].…”

Section: Compositionmentioning

confidence: 99%

Chyawanprash: A Traditional Indian Bioactive Health Supplement

et al. 2019

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Chyawanprash (CP) is an Ayurvedic health supplement which is made up of a super-concentrated blend of nutrient-rich herbs and minerals. It is meant to restore drained reserves of life force (ojas) and to preserve strength, stamina, and vitality, while stalling the course of aging. Chyawanprash is formulated by processing around 50 medicinal herbs and their extracts, including the prime ingredient, Amla (Indian gooseberry), which is the world’s richest source of vitamin C. Chyawanprash preparation involves preparing a decoction of herbs, followed by dried extract preparation, subsequent mixture with honey, and addition of aromatic herb powders (namely clove, cardamom, and cinnamon) as standard. The finished product has a fruit jam-like consistency, and a sweet, sour, and spicy flavor. Scientific exploration of CP is warranted to understand its therapeutic efficacy. Scattered information exploring the therapeutic potential of CP is available, and there is a need to assemble it. Thus, an effort was made to compile the scattered information from ancient Ayurvedic texts and treatises, along with ethnobotanical, ethnopharmacological, and scientifically validated literature, that highlight the role of CP in therapeutics. Citations relevant to the topic were screened.

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Section: Compositionmentioning

confidence: 99%

Chyawanprash: A Traditional Indian Bioactive Health Supplement

et al. 2019

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“…Biofabrication of anti-QS agents like AuNPs from natural renewable resources of biological origin could open up into new ventures for the development of novel nanomaterials to battle MDR P. aregunosa strains infections. AuNPs have been utilized for centuries by vaidya (Sanskrit word meaning ''physician'' refers to a person who practices Ayurveda) and artists due to the medicinal and optical properties [15,16]. More recently, these unique medicinal and optoelectronic potentials have been explored and utilized in high technology applications such as development of therapeutic agents and sensors.…”

Section: Introductionmentioning

confidence: 99%

Intracellular Synthesis of Gold Nanoparticles Using an Ectomycorrhizal Strain EM-1083 of Laccaria fraterna and Its Nanoanti-quorum Sensing Potential Against Pseudomonas aeruginosa

2017

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In this research work different shapes and sizes of gold nanoparticles (AuNPs) were synthesized through an intracellular biogenic approach, exploiting the chloroauric acid reducing and Au stabilizing potential of EM-1083 mycelia. The intracellularly synthesized AuNPs exhibits anti-quorum sensing inhibitory potential against The synthesized AuNPs were characterized using UV-visible spectroscopy; transmission electron microscopy, X-ray diffraction, energy dispersive X-ray spectroscopy, and Fourier transform infrared spectroscopy. The characterization proved that the successful synthesis of highly stable crystalline AuNPs with various shapes. Here we tested inhibitory activity of AuNPs on QS-regulated biofilm development and pyocyanin production traits of .. The qualitative and quantitative data demonstrated that AuNPs significantly inhibited the biofilm formation and pyocyanin production. In summary, our results signify the future use of intracellularly synthesized AuNPs in mediated diseases.

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“…(Jiang et al, 2019). Bhavana -liquid assisted trituration of drug powders (Yadav et al, 2017) and Bhasmikarana -producing drug particles in nano dimensions in the range of 5-50 nm results in improved stability, bioavailability and targeted drug delivery (Sharma and Prajapati, 2016) which could serve as an excellent model for the incorporation of nanoscience with ultrasound for effective drug delivery and better therapeutic cure. By controlling the ultrasound intensity, sonication becomes the ideal method of manufacturing modern ayurvedic drugs in sub-micron and nano-sized dimensions ensuring highest bioavailability.…”

Section: Ultrasound Applicability In Medicinementioning

confidence: 99%

A new drug delivery strategy targeting mass population in combating epidemic crisis

Mohan

Menon

Chacko

et al. 2020

ijrps

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Ultrasound as an alternative model for mass prophylaxis to check outbreaks in epidemics is being proposed in this paper. The outbreak of communicable diseases and mass gathering are certainly related through the obvious risk of transmission of infectious agents. Either as the source or being susceptible, the gathering makes the disease spread rapidly challenging the medical community. To combat the steady rise in the incidence of disease, appropriate control measures need to be adopted. An alternative drug delivery model utilizing the potential of ultrasound through percussion – as medicated drumming is hence presented here taking the reference from Indian traditional system of medicine. In this model the herbal or herbo-mineral drugs applied over drum surface followed by drumming releases biochemicals of high bioavailability. Studies have shown the simultaneous production of ultrasound with audible frequency while playing musical instruments and the high affinity of herbal and herbo-mineral drugs towards it. The particle reduction technology through Bhasmikarana (producing herbo-mineral-metallic compounds in nano dimensions) and Bhavana (liquid-assisted trituration of drug powders) incorporates nanotechnology for better stability, bioavailability and targeted delivery. Sonication as such enables production of herbal drugs in sub-micron and nano-sized dimensions. Hence, this novel approach of medicated drumming integrating nanotechnology along with ultrasonic sound (corresponding to the nanotechnology coupled sonodynamic therapy with improved pharmacokinetics) could function as an efficient drug delivery strategy to check outbreaks.

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Nanotechnology in medicine: Leads from Ayurveda

Cited by 58 publications

References 10 publications

Chyawanprash: A Traditional Indian Bioactive Health Supplement

Chyawanprash: A Traditional Indian Bioactive Health Supplement

Intracellular Synthesis of Gold Nanoparticles Using an Ectomycorrhizal Strain EM-1083 of Laccaria fraterna and Its Nanoanti-quorum Sensing Potential Against Pseudomonas aeruginosa

A new drug delivery strategy targeting mass population in combating epidemic crisis

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