Nanotechnology in ligature-induced periodontitis: protective effect of a doxycycline gel with nanoparticules

Botelho, Marco Antônio; Martins, Jose Galberto; Ruela, Ronaldo; Queiróz, Dinalva Brito de; Ruela, Wagner Sousa

doi:10.1590/s1678-77572010000400003

Cited by 44 publications

(51 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In several studies with similar methodology 6,12,13,18 , but with different substances testing, was found decreased inflammatory response but was not shown difference on the measurement from the cemento-enamel junction, this fact probably occurs because the short time of analysis after application of substances, which is usually after seven days. Thus, further researches are necessary to observe how much time is appropriate to manage the substances for the recovery of bone loss.…”

Section: Resultsmentioning

confidence: 95%

“…Because of the anti-inflammatory and antibacterial agents, the andiroba topically administered or inside dental dentifrices would probably lead to better results. The concentration of the best active principles of the plant associate with mechanic therapy would improve the clinical outcames 13 . New studies are required to verify the effects of the oil in these two distinct ways of administration.…”

Section: Resultsmentioning

confidence: 99%

“…Because of it, researches were conducted in an attempt to improve the clinical management of this condition and is much used the administer of local and systemic antibiotics to control bacteria present on the periondotitis 12,13 . However the antibiotics must be properly used to avoid the selection of new resistant bacteria.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of andiroba oil on periodontitis in Wistar rats

Carmona¹,

Teixeira

Brito

et al. 2013

Acta Cir. Bras.

View full text Add to dashboard Cite

PURPOSE:To evaluate the effects of andiroba oil on the periodontitis in rats. METHODS:The periodontitis was induced by the placement of cotton ligatures around the cervix of the second upper molars on fifteen rats, and waiting fifty days. The animals were randomly distributed into three groups: saline group, andiroba oil group and meloxican group, differentiated by substance used in the treatment of periodontitis. The groups received the respective substance by gavage for seven days, after the periodontitis induced. It was analyzed the score of inflammatory cells and the measurement from the cementoenamel junction to the bone crest. RESULTS:The andiroba oil group (p=0.008) and meloxican group (p=0.0347) show a less score of inflammatory cells than saline group, however there weren't difference between them (p=0.2754). Regarding the analysis of measurement from the cemento-enamel junction to the bone crest, there was no difference between groups studied (p=0.3451). CONCLUSION:Andiroba oil decreased the quantity of inflammatory cells, however, it didn't have an effect on the measurement of alveolar bone loss, like the treatment with Meloxican ® .

show abstract

Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of andiroba oil on periodontitis in Wistar rats

Carmona¹,

Teixeira

Brito

et al. 2013

Acta Cir. Bras.

View full text Add to dashboard Cite

show abstract

“…Botelho et al 45 reported a decrease in bone loss and myeloperoxidase activity in a murine model using a doxycycline gel with nanospheres. In periodontal surgery, current clinical trials suggest the use of nanocrystalline hydroxyapatite paste for the treatment of periodontal intrabony defects, reducing probing depth and gingival recession and increasing clinical attachment level, with the results being similar to those obtained with autogenous grafts 46,47 .…”

Section: Nanotechnology and Dental Applicationsmentioning

confidence: 99%

Nanotechnology in Dentistry

Arruda¹,

Oliveira²,

Paula³

et al. 2017

Arch Health Invest

View full text Add to dashboard Cite

Introduction: Nanotechnology is a rapidly expanding field that encompasses the development, manipulation, and application of structures on the nanometer scale. Applications of nanotechnology to dentistry are particularly promising and comprise materials and devices designed to achieve maximal therapeutic efficacy with minimal side effects. Objective: This review discusses the advantages of nanotechnology and the different types of nanostructures used in dentistry. Material and Method: In this study, online databases: pubmed, medline and scielo were searched to analyse the current understanding of the potential of nanotechnology in dentistry, including the restoration of tooth structure with nanocomposites and the development of nanoparticles for dentin remineralisation, drug delivery, disease diagnostics, oral analgesia, oral hygiene maintenance, local anaesthesia, tooth desensitisation, and bone tissue repair. Results: The study demonstrated a wide range of nanotechnological strategies in different dentistry areas and suggests that nanotechnology-based delivery systems may be very useful to improve treatment, prevention and repair in dentistry in the future. Conclusion: There is little or no clinical experience for the nanotechnology-based drug delivery systems cited herein. Safety assessments and clinical trials are the next step in their development.

show abstract

“…The role of IL-1b and TNF-a, on periodontal disease, has been discussed earlier (Lima et al, 2004;Botelho et al, 2010).…”

Section: Induction Of Experimental Periodontitis and Treatmentmentioning

confidence: 99%

Nanoemulgel (NEG) of Ketoprofen with eugenol as oil phase for the treatment of ligature-induced experimental periodontitis in Wistar rats

et al. 2014

View full text Add to dashboard Cite

Aim: The aim of the novel study was to check the efficacy of a locally applied 2%w/w nanoemulgel (NEG) of Ketoprofen (KP) in preventing the periodontitis, and was also checked NEG without KP to ensure the effect of eugenol in NEG as an oil phase. Design: For experimentally induced periodontitis, sterile silk ligatures (3/0) were placed around the crevices of the first left lower molar teeth of the male Wistar rats. During 8 weeks, all rats were fed with 10%w/v sucrose solution. The experimental assessment was carried out at 11 d after treatment of experimental periodontal disease (EPD) rats by various clinical parameters like gingival index (GI), tooth mobility (TM), alveolar bone loss (ABL), histological analysis, detection of TNF-a, and IL-1b in gingival tissue by ELISA and the roughness were measured by atomic force microscopy (AFM) in tapping modes. Results: After treatment, comparison studies with EPD were performed. NEG loaded with KP prevents significantly (p50.05) various parameters (GI, TM, and ABL), which were responsible for periodontitis. The histopathology of the periodontium showed that Group 3 (NEG loaded with KP) had a more significant reduction in inflammatory cell infiltration, alveolar bones resorption, and cementum (p50.05). In the topographical images, significant reduction in roughness of NEG loaded with KP was observed in comparison with EPD without treatment. Conclusion: The study revealed the great synergistic potential of the combined NEG of an antiinflammatory drug KP along with eugenol as the oil phase, which have potential antibacterial, analgesic, and anesthetic properties to combat periodontal disease.

show abstract

Nanotechnology in ligature-induced periodontitis: protective effect of a doxycycline gel with nanoparticules

Cited by 44 publications

References 24 publications

Effect of andiroba oil on periodontitis in Wistar rats

Effect of andiroba oil on periodontitis in Wistar rats

Nanotechnology in Dentistry

Nanoemulgel (NEG) of Ketoprofen with eugenol as oil phase for the treatment of ligature-induced experimental periodontitis in Wistar rats

Contact Info

Product

Resources

About