Nanotechnology in drug and gene delivery

Hamimed, Selma; Jabberi, Marwa; Chatti, Abdelwaheb

doi:10.1007/s00210-022-02245-z

Cited by 35 publications

(33 citation statements)

References 209 publications

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“…First, the genes must be delivered efficiently and safely to target cells, and second, the modified cells or modifying agents must be monitored using noninvasive imaging. [8] Gene delivery and expression can therefore be tracked. Gene therapeutics is a relatively new approach in itself, so it faces many challenges.…”

Section: Drug Deliverymentioning

confidence: 99%

“…They improve pharmacokinetics and respond to permeation and retention at the tumor site, and also play a crucial role due to how easily they are synthesized and their flexible properties. [8] Another type of carrier are the lipid-based nanocarriers, which are also efficient vectors in delivering genes. They are used to encapsulate RNA, and are created by a combination of a lipid solution and plasmid DNA.…”

Section: Drug Deliverymentioning

confidence: 99%

“…The particle surfaces hold positively charged molecules like peptides, amino acids, or oligonucleotides. [8] Often in conjunction with chemotherapy or gene therapy, cancer patients will receive radiation to further limit the growth of cancer cells. This is done so by damaging their DNA and inducing cellular death by altering the DNA directly or by creating charged atoms that will.…”

Section: Drug Deliverymentioning

confidence: 99%

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Nanotechnology and its Role in Cancer Treatment and Diagnosis

Feng¹

2023

HSET

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Globally, cancer is one of the leading causes of death and is extremely difficult to treat and diagnose. The numerous types and variations of the disease make it a complex illness to tackle. Often, a patient diagnosed with cancer will face a drastic reduction in quality of life, if not death. One of the biggest challenges regarding cancer is early detection and toxic therapies. Over the past few years, the two factors have been improved upon by the employment of nanotechnology via innovations in tumor imaging and reducing toxicity in drug delivery. Various nanocarriers and materials such as liposomes and nanotubes have shown improvement in target specificity and enhanced imaging. They preserve healthy tissue cells to a greater degree and can aid in accurately detecting cancer before metastasis. In this paper, there will be (i) an overview of various nanoparticles and their advantages, (ii) how nanocarriers are applied in cancer diagnosis and treatment, (iii) the developmental path of nanotechnology methods, and (iv) future prospects of nanotechnology development.

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Section: Drug Deliverymentioning

confidence: 99%

Section: Drug Deliverymentioning

confidence: 99%

Section: Drug Deliverymentioning

confidence: 99%

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Nanotechnology and its Role in Cancer Treatment and Diagnosis

Feng¹

2023

HSET

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“…Solid lipid nanoparticles (SLNs) have emerged as promising colloidal drug delivery systems owing to their interesting properties. 42 Though SLNs have been investigated widely to deliver different classes of drugs such as anticancer drugs, Alzheimer's drugs, antimicrobial agents [43][44][45] efficiently at the target site, encapsulation of hydrophilic drugs in the SLNs still remains challenging because of insufficient affinity between the drug and lipid matrix.…”

Section: Preparation and Optimization Of Formulationmentioning

confidence: 99%

Poly(N-vinylcaprolactam) containing solid lipid polymer hybrid nanoparticles for controlled delivery of a hydrophilic drug gemcitabine hydrochloride

Surapaneni

Ambade

2022

RSC Adv.

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“…Nanotechnology has been used in various fields, such as medicines for diagnostics and drug delivery. [8,9] Nanomedicines have been widely studied for over 30 years, including liposomes, micelles and nanoparticles. [10,11] The use of nanoparticles for pulmonary drug delivery is of increasing global concern.…”

Section: Introductionmentioning

confidence: 99%

Pollen‐Inspired Shell–Core Aerosol Particles Capable of Brownian Motion for Pulmonary Vascularization

Chen

Xiang

et al. 2023

Advanced Materials

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Nebulization is the most widely used respiratory delivery technique with non‐invasive properties. However, nebulized drugs often fail to function due to the excretion and immune clearance of the respiratory system. In this work, inspired by pollen in nature, novel shell–core aerosol particles (APs) capable of Brownian motion are constructed for respiratory delivery. Drugs‐loaded poly(lactic‐co‐glycolic acid) nanoparticles are prepared by emulsification to form the inner core, and the membranes of macrophages are extracted to form the outer shell. The optimized size and the shell–core structure endow APs with Brownian motion and atomization stability, thus enabling the APs to reach the bronchi and alveoli deeply for effective deposition. Camouflaging the macrophage membranes equips the APs with immune evasion. In vitro experiments prove that deferoxamine (DFO)‐loaded APs (DFO@APs) can promote the angiogenesis of human umbilical vein endothelial cells. A hyperoxia‐induced bronchopulmonary dysplasia (BPD) model is constructed to validate the efficiency of DFO@APs. In BPD mice, DFO@APs can release DFO in the alveolar interstitium, thus promoting the reconstruction of microvasculature, ultimately inducing lung development for treating BPD. In conclusion, this study develops “pollen”‐inspired shell–core aerosol particles capable of Brownian motion, which provides a novel idea and theoretical basis for respiratory administration.

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Nanotechnology in drug and gene delivery

Cited by 35 publications

References 209 publications

Nanotechnology and its Role in Cancer Treatment and Diagnosis

Nanotechnology and its Role in Cancer Treatment and Diagnosis

Poly(N-vinylcaprolactam) containing solid lipid polymer hybrid nanoparticles for controlled delivery of a hydrophilic drug gemcitabine hydrochloride

Pollen‐Inspired Shell–Core Aerosol Particles Capable of Brownian Motion for Pulmonary Vascularization

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