Nanotechnology for Cerebral Aneurysm Treatment

Surface Modification of Bacterial Cellulose for Biomedical Applications

“…Moreover, BC possesses high purity with high water retaining capacity, easily modifiable biodegradability, biocompatibility with facile production, purification and mouldability. The micromorphology of BC has a distinctive network of cellulose nanofiber consisting of unique feature rendering them as oil absorbents, fuel cell, catalyst and biomedical applications such as drug delivery, tissue engineering, skin repair and wound dressing [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ].…”

“…BC has become a popular choice with research in emerging applications in both tissue engineering and regenerative medicine. Tissue engineering and regenerative medicine, attempt to create functional human tissues from cells by repairing or replacing tissue in organs which may fail due to disease, genetic errors, congenital abnormalities, or traumatic injury [ 24 , 25 ]. While tissue engineering encompasses the scaffolds and growth factors which affects the regeneration or replacement of damaged tissues, regenerative medicine circumscribes cell therapy, gene therapy and immunomodulation to encourage tissue or organ repair or reconstruction inside the body.…”

“…In some cases, the designed scaffold dissolve overtime while in others they remain to provide lifelong strength, endurance and support to the system which mimic the organs. Damage to blood vessel walls also known as aneurysms can be a critical trauma leading to high fatality rates [ 24 ]. Clipping and endovascular coiling by surgery are the conventional treatment for such conditions with the serious risk of thrombus formation as post-surgical complication.…”

Simulación dinámica computacional de la hemodinámica de un aneurisma cerebral bajo la acción de un campo magnético externo

“…El objetivo de todos los tratamientos del aneurisma es obstruir el flujo de sangre hacia el saco del aneurisma. Recientemente, algunos autores han postulado opciones para promover la oclusión del cuello del aneurisma promoviendo el crecimiento del tejido faltante en un proceso denominado reendotelización [15][16][17]. Las opciones propuestas incluyen, teniendo como referencia el tratamiento endovascular, posicionar un soporte estructural que a partir de la atracción de células endoteliales (EC) logre inducir el crecimiento de tejido en la región del ostium, cerrando el cuello del aneurisma con tejido vascular, aliviando el flujo de sangre y la presión en el saco, reduciendo significativamente e incluso eliminando la posibilidad de una ruptura tardía o un daño en el tejido circundante.…”

Effects of Uniform Magnetic Field on the Non-Newtonian Hemodynamics of a Saccular Brain Aneurysm 3d Model

“…The tissue regeneration at the neck of saccular brain aneurysm has been previously investigated, as a treatment that enable thrombogenic occlusion. It has been proposed to use magnetic fields to recruit endothelial cells present in the blood to the aneurysm neck region (Allain et al 2013). However, to date there is a paucity of understanding about the disturbed flow behavior that includes the complex hemodynamic environment of the blood flow under magnetic fields (Mirzababaei et al 2017).…”