Nanotechnology: Conservative Dentistry and Endodontics

Chole, Dayanand; Khan, Irshad; Kundoor, Shashank; Bakle, Srinivas; Gandhi, Neha; Deshpande, Rucha

doi:10.9790/0853-160401102107

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…This hydration reaction and setting time are affected by the availability of water, and setting time may be prolonged in overly dried canals. Nanosized particles facilitate the delivery of material from 0.012 mm fine needles and adapt to irregular dentin surfaces, providing excellent seal and dimensional stability [45].…”

Section: Root Canal Sealersmentioning

confidence: 99%

Applications of Nanotechnology in Endodontics: A Narrative Review

Boitsaniuk,

Kochan,

Levkiv

2023

Nanoarchitectonics

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The term “nanodentistry” was first introduced at the beginning of the 21st century. In recent decades,nanotechnology has progressed significantly, creating numerous opportunities for application in various biomedicalfields. In particular, the use of nanoparticles in endodontics has attracted considerable interest due to their uniquecharacteristics. As a result of their nano-size, nanoparticles possess several properties that can improve the treatment ofendodontic infections, such as increased antibacterial activity, increased reactivity, and the ability to be functionalizedwith other reactive compounds. Materials whose size is less than 100 nm in at least one dimension are referred to asnanomaterials. Among nanoparticles can be found grains, fibers, clusters, nano-holes, or their combinations. The mainfeature of nanoparticles is their large surface area per unit mass compared to bulk matter. Due to their large surface area,nanoparticles have significantly modified the physical and chemical properties of the material in comparison to bulkmatter. Nanoparticles with their modified and specific physicochemical properties, such as ultra-small size, large surfacearea/mass ratio, and increased chemical reactivity, have opened new prospects in endodontics. For the present study, anelectronic search was done using MEDLINE (PubMed), Google Scholar, and open-access journals that are publishedby Elsevier. For search words and phrases: «nanotechnology», «nanotechnology in dentistry», and «classification ofnanoparticles» were used in various combinations. Forty articles were found, from which 16 were selected. The selecteditems include research and review articles. This review provides insights into the unique characteristics of nanoparticles,including their chemical, physical, and antimicrobial properties; limitations; and potential uses. Various studiesconcerning different methods of using nanoparticles in endodontics have been thoroughly studied. Based on previousclinical studies, methods of nanoparticle use in endodontics were evaluated. The findings indicate that nanoparticleapplications in endodontics have a lot of potential.

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Section: Root Canal Sealersmentioning

confidence: 99%

Applications of Nanotechnology in Endodontics: A Narrative Review

Boitsaniuk,

Kochan,

Levkiv

2023

Nanoarchitectonics

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“…In the field of regenerative endodontics, nanobiomaterials are employed to create advanced scaffolds and facilitate the controlled delivery of growth factors, contributing to more successful regenerative procedures [4]. Furthermore, NPs are being investigated for their antibacterial properties, to eliminate biofilms and bacteria within the root canal system [5].…”

Section: Introductionmentioning

confidence: 99%

Enhancing Antimicrobial Efficacy and Synergistic Effects of Nano-Silica-Based Combinations With Doxycycline, Metronidazole, and Ciprofloxacin Against Enterococcus faecalis Biofilms

Hameed,

Antony,

Shanmugam

et al. 2024

Cureus

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Background: Enterococcus faecalis biofilm formation within root canals poses a challenging problem in endodontics, often leading to treatment failure. To combat this issue, nanotechnology offers a promising avenue for enhancing antimicrobial efficacy. This study explores the potential synergistic effects of combining nanoscale silica particles with conventional antibiotics, including doxycycline, metronidazole, and ciprofloxacin, against E. faecalis biofilms. The unique characteristics of silica nanoparticles, such as their increased reactivity and ability to be functionalized with other compounds, make them ideal candidates for augmenting antibiotic efficacy. This research investigates the antimicrobial properties of these silica-based combinations and their potential to eliminate or inhibit E. faecalis biofilms more effectively than conventional treatments.Methodology: The methods involved the preparation of nanostructured silica particles and their combination with doxycycline, Flagyl, and ciprofloxacin at subinhibitory concentrations. These combinations were then tested against E. faecalis biofilms using the agar well diffusion technique.Results: Preliminary results suggested that the synergistic interactions between silica nanoparticles and antibiotics can significantly enhance antimicrobial efficacy. The combined treatment exhibited superior inhibitory effects on E. faecalis compared to antibiotics or silica nanoparticles alone (P < 0.05).Conclusions: This study sheds light on the potential of nanoscale silica-based combinations to address the challenges posed by E. faecalis biofilms in endodontics. Understanding the mechanisms of synergy between nanoparticles and antibiotics can pave the way for the development of more effective and targeted strategies for root canal disinfection, ultimately improving the success rates of endodontic treatments.

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