Nanotechnology-Based Strategies for Effective and Rapid Detection of SARS-CoV-2

Moabelo, Koena Leah; Martin, Darius Riziki; Fadaka, Adewale Oluwaseun; Sibuyi, Nicole Remaliah Samantha; Meyer, Mervin; Madiehe, Abram Madimabe

doi:10.3390/ma14247851

Cited by 13 publications

(8 citation statements)

References 135 publications

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“…However, it was found that some new techniques of QDs for SARS-CoV-2 detection could be borrowed for LFIA, thus providing excellent new options for POCT continuously. For example, a QDs method for the quantitative detection of SARS-CoV-2 IgG reported in the study by Moabelo et al has an excellent detection limit of 4 pg/ml, which is a cause for concern ( Moabelo et al, 2021 ). The method is a highly sensitive QDs-linked immunoassay based on QDs nanoparticles and magnetic iron oxide (MnFe3O4) nanomicrospheres.…”

Section: Lfia Technique For Sars-cov-2 Antibody Detectionmentioning

confidence: 99%

Rapid detection of SARS-CoV-2: The gradual boom of lateral flow immunoassay

Zhu

Zhou

et al. 2023

Front. Bioeng. Biotechnol.

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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is still in an epidemic situation, which poses a serious threat to the safety of people and property. Rapid diagnosis and isolation of infected individuals are one of the important methods to control virus transmission. Existing lateral flow immunoassay techniques have the advantages of rapid, sensitive, and easy operation, and some new options have emerged with the continuous development of nanotechnology. Such as lateral flow immunoassay test strips based on colorimetric-fluorescent dual-mode and gold nanoparticles, Surface Enhanced Raman Scattering, etc., these technologies have played an important role in the rapid diagnosis of COVID-19. In this paper, we summarize the current research progress of lateral flow immunoassay in the field of Severe Acute Respiratory Syndrome Coronavirus 2 infection diagnosis, analyze the performance of Severe Acute Respiratory Syndrome Coronavirus 2 lateral flow immunoassay products, review the advantages and limitations of different detection methods and markers, and then explore the competitive CRISPR-based nucleic acid chromatography detection method. This method combines the advantages of gene editing and lateral flow immunoassay and can achieve rapid and highly sensitive lateral flow immunoassay detection of target nucleic acids, which is expected to be the most representative method for community and clinical point-of-care testing. We hope that researchers will be inspired by this review and strive to solve the problems in the design of highly sensitive targets, the selection of detection methods, and the enhancement of CRISPR technology, to truly achieve rapid, sensitive, convenient, and specific detection of novel coronaviruses, thus promoting the development of novel coronavirus diagnosis and contributing our modest contribution to the world’s fight against epidemics.

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Section: Lfia Technique For Sars-cov-2 Antibody Detectionmentioning

confidence: 99%

Rapid detection of SARS-CoV-2: The gradual boom of lateral flow immunoassay

Zhu

Zhou

et al. 2023

Front. Bioeng. Biotechnol.

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“…NAATs are the gold standard diagnostic for SARS-CoV-2 infection (Tyagi et al, 2020). SARS-CoV-2 has developed many mutations that can result in immune escape (Moabelo et al, 2021). Since NAATs use nucleic acid primers to recognize and amplify their targets, the incorporation of one or more base substitutions into the targeted nucleotide sequence is potentially sufficient to inhibit the reaction.…”

Section: Therapeuticsmentioning

confidence: 99%

Nanotechnology and COVID-19: Prevention, diagnosis, vaccine, and treatment strategies

Ayan

Aranci-Ciftci²,

Çiftçi³

et al. 2023

Front. Mater.

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In December 2019, Coronavirus pandemic (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) viruses, which affected the whole world, is emerged. The details on the epidemiology, infection source, transmission mode, and prognosis of SARS-CoV-2 gave in this review. Universal infection control standards such as hand hygiene, environmental cleanliness, use of personal protective equipment, and quarantine used to prevent the spread of COVID-19 without vaccine. However, many vaccine candidate studies carried out globally with using traditional and technological approaches. Innovations in technology allow the development of nanotechnological tools and the formation of systems that will inactivate SARS-CoV-2 in patients. It expected to include technologies that combine different disciplines, especially robotic applications, antimicrobial nanotechnology, and tissue engineering for the future treatment of COVID-19. This review-based work discusses the relationship of COVID-19 and nanotechnology based working principles.

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“…Nanosensors based on magnetic nanoparticles (MNPs) generate heat as a result of their optical properties when aggregate vibrations in energy concentration take place at the interface of nanomaterial via conjugating to magnetic radiation. The increased frequency of collisions with lattice atoms caused by the enhanced motion of conduction electrons leads to the generation of PT-induced heat (Hofmann et al 2008 ; Moabelo et al 2021 ; Esbin et al 2020 ).…”

Section: Diagnosis Of Sars-cov-2 Infestationmentioning

confidence: 99%

Superior possibilities and upcoming horizons for nanoscience in COVID-19: noteworthy approach for effective diagnostics and management of SARS-CoV-2 outbreak

Bhattacharjee¹,

Ikbal

Farooqui

et al. 2023

Chem. Pap.

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The outbreak of COVID-19 has caused great havoc and affected many parts of the world. It has imposed a great challenge to the medical and health fraternity with its ability to continue mutating and increasing the transmission rate. Some challenges include the availability of current knowledge of active drugs against the virus, mode of delivery of the medicaments, its diagnosis, which are relatively limited and do not suffice for further prognosis. One recently developed drug delivery system called nanoparticles is currently being utilized in combating COVID-19. This article highlights the existing methods for diagnosis of COVID-19 such as computed tomography scan, reverse transcription-polymerase chain reaction, nucleic acid sequencing, immunoassay, point-of-care test, detection from breath, nanotechnology-based bio-sensors, viral antigen detection, microfluidic device, magnetic nanosensor, magnetic resonance platform and internet-of-things biosensors. The latest detection strategy based on nanotechnology, biosensor, is said to produce satisfactory results in recognizing SARS-CoV-2 virus. It also highlights the successes in the research and development of COVID-19 treatments and vaccines that are already in use. In addition, there are a number of nanovaccines and nanomedicines currently in clinical trials that have the potential to target COVID-19.

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Nanotechnology-Based Strategies for Effective and Rapid Detection of SARS-CoV-2

Cited by 13 publications

References 135 publications

Rapid detection of SARS-CoV-2: The gradual boom of lateral flow immunoassay

Rapid detection of SARS-CoV-2: The gradual boom of lateral flow immunoassay

Nanotechnology and COVID-19: Prevention, diagnosis, vaccine, and treatment strategies

Superior possibilities and upcoming horizons for nanoscience in COVID-19: noteworthy approach for effective diagnostics and management of SARS-CoV-2 outbreak

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