Nanotechnology-based materials as emerging trends for dental applications

Barot, Tejas; Rawtani, Deepak; Kulkarni, Pratik

doi:10.1515/rams-2020-0052

Cited by 43 publications

(24 citation statements)

References 131 publications

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“…In order to restore dental enamel, a number of various materials have been developed, such as composite resins and ceramics [ 60 , 61 ]; however, their application could not result in the achievement of a stable restoration due to imperfections in the combination of the utilized materials and the native dental tissue [ 12 , 62 ]. Therefore, a tendency to reproduce the native structure of the natural hard dental tissue [ 13 , 14 , 62 ] with the use of biomimetic composites involving nanocrystalline carbonate-substituted hydroxyapatite in its composition is in the basis of the doctrine of current therapeutic dentistry.…”

Section: Discussionmentioning

confidence: 99%

“…Biomimetic composites containing an organic matrix and inorganic phosphate components are promising materials for restorative and regenerative dentistry, surgery and bone grafting [ 1 , 2 , 3 ]. The synthesis of such hybrid biomaterials, reproducing the physicochemical properties of human hard tissues [ 4 , 5 , 6 , 7 , 8 ], as well as the modification of biomaterials with different inorganic bioactive ions and molecular groups in order to initiate the controlled reaction in tissues and to provide antimicrobic activity, is a complex and multilevel task [ 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the Effect of Nanocrystalline Calcium Carbonate-Substituted Hydroxyapatite and L-Lysine and L-Arginine Surface Interactions on the Molecular Properties of Dental Biomimetic Composites

et al. 2021

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Differences in the surface interactions of non-stoichiometric nanocrystalline B-type carbonate-substituted hydroxyapatite (n-cHAp) with the amino acids L-Lysine hydrochloride (L-LysHCl) and L-Arginine hydrochloride (L-ArgHCl) in acidic and alkaline media were determined using structural and spectroscopic analysis methods. The obtained data confirm that hydroxyapatite synthesized using our technique, which was used to develop the n-cHAp/L-LysHCl and n-cHAp/L-ArgHCl composites, is nanocrystalline. Studies of molecular composition of the samples by Fourier transform infrared spectroscopy under the change in the charge state of L-Lysine in environments with different alkalinity are consistent with the results of X-ray diffraction analysis, as evidenced by the redistribution of the modes’ intensities in the spectra that is correlated with the side chains, i.e., amide and carboxyl groups, of the amino acid. During the formation of a biomimetic composite containing L-Lysine hydrochloride and n-cHAp, the interaction occurred through bonding of the L-Lysine side chain and the hydroxyl groups of hydroxyapatite, which created an anionic form of L-Lysine at pH ≤ 5. In contrast, in biocomposites based on L-Arginine and n-cHAp, the interaction only slightly depends on pH value, and it proceeds by molecular orientation mechanisms. The X-ray diffraction and infrared spectroscopy results confirm that changes in the molecular composition of n-cHAp/L-ArgHCl biomimetic composites are caused by the electrostatic interaction between the L-ArgHCl molecule and the carbonate-substituted calcium hydroxyapatite. In this case, the bond formation was detected by Fourier transform infrared (FTIR) spectroscopy; the vibrational modes attributed to the main carbon chain and the guanidine group of L-Arginine are shifted during the interaction. The discovered interaction mechanisms between nanocrystalline carbonate-substituted hydroxyapatite that has physicochemical properties characteristic of the apatite in human dental enamel and specific amino acids are important for selecting the formation conditions of biomimetic composites and their integration with the natural dental tissue.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Investigation of the Effect of Nanocrystalline Calcium Carbonate-Substituted Hydroxyapatite and L-Lysine and L-Arginine Surface Interactions on the Molecular Properties of Dental Biomimetic Composites

et al. 2021

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“…However, in spite of intensive investigations in this area of biomaterial science, approaches concerning the creation of materials with the functional characteristics of enamel and dentine still remain to be research-based, as most prospective current biomaterials are inferior to the native tissue. The main obstacle here is still the great existing difference in the functional properties of biocomposites relative to those that are inherent to hard natural tissues (low chemical tropism to the native tissue by its physical properties: mechanical strength, elasticity, optical and light emission characteristics, cytotoxicity [14][15][16][17][18]). All of these enumerated properties directly depend not only on the type of nanostructure defect and the morphology of calcium hydroxyapatite applied for their fabrication, but also on its hierarchical organization as well as on the type of interaction with the organic matrix in the biomimetic composite [19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Raman and XANES Spectroscopic Study of the Influence of Coordination Atomic and Molecular Environments in Biomimetic Composite Materials Integrated with Dental Tissue

et al. 2021

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In this work, for the first time, the influence of the coordination environment as well as Ca and P atomic states on biomimetic composites integrated with dental tissue was investigated. Bioinspired dental composites were synthesised based on nanocrystalline calcium carbonate-substituted hydroxyapatite Ca4ICa6IIPO46−xCO3x+yOH2−y (nano-cHAp) obtained from a biogenic source and a set of polar amino acids that modelled the organic matrix. Biomimetic composites, as well as natural dental tissue samples, were investigated using Raman spectromicroscopy and synchrotron X-ray absorption near edge structure (XANES) spectroscopy. Molecular structure and energy structure studies revealed several important features related to the different calcium atomic environments. It was shown that biomimetic composites created in order to reproduce the physicochemical properties of dental tissue provide good imitation of molecular and electron energetic properties, including the carbonate anion CO32− and the atomic Ca/P ratio in nanocrystals. The features of the molecular structure of biomimetic composites are inherited from the nano-cHAp (to a greater extent) and the amino acid cocktail used for their creation, and are caused by the ratio between the mineral and organic components, which is similar to the composition of natural enamel and dentine. In this case, violation of the nano-cHAp stoichiometry, which is the mineral basis of the natural and bioinspired composites, as well as the inclusion of different molecular groups in the nano-cHAp lattice, do not affect the coordination environment of phosphorus atoms. The differences observed in the molecular and electron energetic structures of the natural enamel and dentine and the imitation of their properties by biomimetic materials are caused by rearrangement in the local environment of the calcium atoms in the HAp crystal lattice. The surface of the nano-cHAp crystals in the natural enamel and dentine involved in the formation of bonds with the organic matrix is characterised by the coordination environment of the calcium atom, corresponding to its location in the CaI position—that is, bound through common oxygen atoms with PO4 tetrahedrons. At the same time, on the surface of nano-cHAp crystals in bioinspired dental materials, the calcium atom is characteristically located in the CaII position, bound to the hydroxyl OH group. The features detected in the atomic and molecular coordination environment in nano-cHAp play a fundamental role in recreating a biomimetic dental composite of the natural organomineral interaction in mineralised tissue and will help to find an optimal way to integrate the dental biocomposite with natural tissue.

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“…It is worth noting that the antibacterial properties of prosthetic materials used for obtaining implant-supported prostheses play a very important role in the longevity of dental implants [ 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 ]. The antibacterial capacity of natural polymers [ 129 , 130 , 131 ], the addition of antimicrobial agents in polymer matrix [ 129 , 132 ], antibacterial coatings of both dental implants and prosthetic materials [ 133 , 134 ], and the incorporation of metallic, ceramic, or polymeric antimicrobial nanoparticles [ 133 , 134 , 135 , 136 ] may prevent microbial colonization, infection, and subsequent oral implant failure [ 133 ]. The multifunctional antimicrobial materials not only fight against oral infections, but they can promote the efficacy of medical devices as well [ 128 ].…”

Section: Definitive Prosthetic Materials Used For Obtaining Oral Impl...mentioning

confidence: 99%

Prosthetic Materials Used for Implant-Supported Restorations and Their Biochemical Oral Interactions: A Narrative Review

et al. 2022

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The purpose of this study is to outline relevant elements regarding the biochemical interactions between prosthetic materials used for obtaining implant-supported restorations and the oral environment. Implant-supported prostheses have seen unprecedented development in recent years, benefiting from the emergence of both new prosthetic materials (with increased biocompatibility and very good mechanical behavior), and computerized manufacturing technologies, which offer predictability, accuracy, and reproducibility. On the other hand, the quality of conventional materials for obtaining implant-supported prostheses is acknowledged, as they have already proven their clinical performance. The properties of PMMA (poly (methyl methacrylate))—which is a representative interim material frequently used in prosthodontics—and of PEEK (polyether ether ketone)—a biomaterial which is placed on the border between interim and final prosthetic use—are highlighted in order to illustrate the complex way these materials interact with the oral environment. In regard to definitive prosthetic materials used for obtaining implant-supported prostheses, emphasis is placed on zirconia-based ceramics. Zirconia exhibits several distinctive advantages (excellent aesthetics, good mechanical behavior, biocompatibility), through which its clinical applicability has become increasingly wide. Zirconia’s interaction with the oral environment (fibroblasts, osteoblasts, dental pulp cells, macrophages) is presented in a relevant synthesis, thus revealing its good biocompatibility.

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Nanotechnology-based materials as emerging trends for dental applications

Cited by 43 publications

References 131 publications

Investigation of the Effect of Nanocrystalline Calcium Carbonate-Substituted Hydroxyapatite and L-Lysine and L-Arginine Surface Interactions on the Molecular Properties of Dental Biomimetic Composites

Investigation of the Effect of Nanocrystalline Calcium Carbonate-Substituted Hydroxyapatite and L-Lysine and L-Arginine Surface Interactions on the Molecular Properties of Dental Biomimetic Composites

Raman and XANES Spectroscopic Study of the Influence of Coordination Atomic and Molecular Environments in Biomimetic Composite Materials Integrated with Dental Tissue

Prosthetic Materials Used for Implant-Supported Restorations and Their Biochemical Oral Interactions: A Narrative Review

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