Nanotechnology-based artificial platelets

Alam, Feroz; Naim, Mohammed; Rahman, Suhail-ur; Shadan, Mariam

doi:10.4103/1110-1067.124836

Cited by 2 publications

(1 citation statement)

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“…The H12 dodecapeptide facilitates platelet aggregation and hemostatic plug formation, whereas the ADP-encapsulated liposome mediates the aggregation-dependent controlled release of ADP at the site of injury to further enhance the blood clot. 69,70 Dyer et al have developed SynthoPlate liposomes, which are made of collagen and functionalized with von Willebrand factorbinding peptides (to mimic platelet adhesion) and fibrinogen-mimetic peptide (to promote platelet aggregation). 71 This synthetic platelet (SynthoPlate) has reduced blood loss compared to the control in a mouse liver model with non-compressible intraperitoneal hemorrhage (internal bleeding in the peritoneal cavity, which cannot be controlled by compression.…”

Section: Peptide-based Intravenous Hemostatmentioning

confidence: 99%

Peptide-based topical agents and intravenous hemostat for rapid hemostasis

et al. 2020

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Section: Peptide-based Intravenous Hemostatmentioning

confidence: 99%

Peptide-based topical agents and intravenous hemostat for rapid hemostasis

et al. 2020

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Evaluation of the effects of nanoparticles on the therapeutic function of platelet: a review

Mehrizi

Kafiabad

2021

Journal of Pharmacy and Pharmacology

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Objectives Nanotechnology and nanoparticles are used in different applications in disease monitoring and therapy in contact with blood. Nanoparticles showed different effects on blood components and reduced or improved the function of therapeutic platelet during the storage time. This review study was performed to evaluate the impacts of various sizes and charges of nanoparticles on platelet function and storage time. The present review contains the literature between 2010 and 2020. The data have been used from different sites such as PubMed, Wiley, ScienceDirect and online electronic journals. Key findings From the literature survey, it has been demonstrated that among various properties, size and charge of nanoparticles were critical on the function of therapeutic platelet during the storage and inhibition of their aggregation. Overall, this study described that nanoparticles with smaller size and negative charge were more effective in increasing the survival time, inhibition of aggregation and improving the function of therapeutic platelet. Summary Based on the current review, it can be confirmed that nanoparticles such as dendrimer, Au, Ag and iron oxide nanoparticles with smaller size and negative charge have significant advantages for improving the efficacy of platelets during the storage chain and inhibition of their aggregation.

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Nanotechnology-based artificial platelets

Cited by 2 publications

References 0 publications

Peptide-based topical agents and intravenous hemostat for rapid hemostasis

Peptide-based topical agents and intravenous hemostat for rapid hemostasis

Evaluation of the effects of nanoparticles on the therapeutic function of platelet: a review

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