Peptide-based topical agents and intravenous hemostat for rapid hemostasis

Ghosh, Snehasish; Tripathi, Archana; Gayen, Paramita; Roy, Ranabir Sinha

doi:10.1039/d0md00204f

Cited by 10 publications

(13 citation statements)

References 70 publications

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“…and synthetic hemostatic agents (e.g., liposomes, PLGA nanoparticles, polySTAT, etc.) . By imitating or combining appropriate peptide sequences, these hemostatic medicines are able to target and identify bleeding sites. , Table summarizes the reported cellular and synthetic hemostats and their mechanisms of action.…”

Section: Progress In Targeting Intravenous Hemostatmentioning

confidence: 99%

Intravenous Hemostats: Foundation, Targeting, and Controlled-Release

et al. 2022

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Uncontrollable blood loss is the greatest cause of mortality in prehospital patients and the main source of disability and death in hospital care. Compared with external hemostats, intravenous hemostats are more appropriate for preventing and treating uncontrolled bleeding in vivo and large bleeding on the body surface. This Review initially establishes intravenous hemostats' response basis, including the coagulation mechanism, fibrinolytic pathway, and protein corona. Second, the study of advancement of intravenous hemostat targeting was expanded from two perspectives, cellular hemostatic agents and synthetic hemostatic agents. Meanwhile, after discussing the progress of controlled-release intravenous hemostats with platelets as the stimuli, this Review offers insight into the possibility of controlled-release intravenous hemostats with microenvironment as the stimuli, combining the studies of controlled-release targeted thrombolysis.

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Section: Progress In Targeting Intravenous Hemostatmentioning

confidence: 99%

Intravenous Hemostats: Foundation, Targeting, and Controlled-Release

et al. 2022

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“…Blood clotting is a complex process. It involves numerous protein factors to play significant roles [1b] . The entire process can be broken down into two stages:…”

Section: Physiological Mechanism Of Blood Clotting and Wound Healingmentioning

confidence: 99%

“…The primary homeostasis: This is the process of formation of a weak platelet plug at the site of injury. In case of any injury, the blood vessel walls constrict to regulate blood flow, allowing the formation of a platelet plug at the site of injury [1b] …”

Section: Physiological Mechanism Of Blood Clotting and Wound Healingmentioning

confidence: 99%

“…Patients with bleeding disorder face life threatening situations during surgery. Several techniques including suture, gauze pressure, laser techniques, electro cauterization are used by clinicians for handling uncontrolled bleeding, which have limitations including the use of electrode based thermal devices, cauterization by using heat or laser or applying pressure by mechanical methods etc [1b,6] . Conventional suturing supports mainly primary wound closure, but not recommended for soft tissue repairs, especially for lungs and nerves [6b] .…”

Section: Introductionmentioning

confidence: 99%

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Engineered Bio‐inspired Multifunctional Peptide‐ and Protein‐based Therapeutic Biomolecules for Better Wound Care

Gayen

Jan

Chowdhury

et al. 2021

Chemistry An Asian Journal

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Developing non-immunogenic therapeutic biomolecules for facilitating blood clotting followed by wound healing via therapeutic angiogenesis, still remains a formidable challenge. Excessive blood loss of accident victims and battalions cause a huge number of deaths worldwide. Patients with inherited bleeding disorders face acute complications during injury and post-surgery. Biologically-inspired peptide-based hemostat can act as a potential therapeutic for handling coagulopathy. Additionally, non-healing wounds for patients having ischemic diseases can cause severe clinical complications. Advancement in stabilized growth-factorbased proangiogenic therapy may offer effective possibilities for the treatment of ischemic pathology. This review will discuss nature-inspired biocompatible stabilized peptide-and protein-based molecular medicines to serve unmet medical challenges for handling traumatic coagulopathy and impaired wound healing.

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“…of the polysaccharides are disparate, which can endow them with various hemostatic characteristics as detailed in the following sections. Similarly, polypeptides, which are abundant in tissue and blood, play a vital role in coagulation and can be utilized as the key point for hemostatic material design [ 11 , 12 ]. Furthermore, many functional groups have recently been introduced into the biopolymers to modify their physical and physiological properties, making them smart and multifunctional.…”

Section: Introductionmentioning

confidence: 99%

Design of biopolymer-based hemostatic material: Starting from molecular structures and forms

Zou¹,

Li²,

Hu³

et al. 2022

Materials Today Bio

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Peptide-based topical agents and intravenous hemostat for rapid hemostasis

Abstract: These article features about peptide based topical and intravenous hemostat.

Cited by 10 publications

References 70 publications

Intravenous Hemostats: Foundation, Targeting, and Controlled-Release

Intravenous Hemostats: Foundation, Targeting, and Controlled-Release

Engineered Bio‐inspired Multifunctional Peptide‐ and Protein‐based Therapeutic Biomolecules for Better Wound Care

Design of biopolymer-based hemostatic material: Starting from molecular structures and forms

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