Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control

Liu, Yong; Shi, Linqi; Su, Linzhu; Mei, Henny C. van der; Jutte, Paul C.; Ren, Yijin; Busscher, Henk J.

doi:10.1039/c7cs00807d

Cited by 517 publications

(461 citation statements)

References 53 publications

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“…Large biomolecules mainly include AMPs and antibacterial proteins that disrupt bacterial cell membranes. While both AMPs and antibacterial proteins are regarded as promising candidates to address the challenge of multidrug‐resistant bacteria, their efficacy is hindered by limited uptake efficacy and the fragile nature of biomolecules, which can be easily degraded . In addition, their stability may be influenced by ionic strength and pH, and the high cost of the production and purification of large biomolecules is another issue in practical applications .…”

Section: Nanomaterials For Antibiotic‐free Antibacterial Applicationsmentioning

confidence: 99%

Antibiotic‐Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives

et al. 2019

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.201904106.Bacterial infection is one of the top ten leading causes of death globally and the worst killer in low-income countries. The overuse of antibiotics leads to ever-increasing antibiotic resistance, posing a severe threat to human health. Recent advances in nanotechnology provide new opportunities to address the challenges in bacterial infection by killing germs without using antibiotics. Antibiotic-free antibacterial strategies enabled by advanced nanomaterials are presented. Nanomaterials are classified on the basis of their mode of action: nanomaterials with intrinsic or light-mediated bactericidal properties and others that serve as vehicles for the delivery of natural antibacterial compounds. Specific attention is given to antibacterial mechanisms and the structureperformance relationship. Practical antibacterial applications employing these antibiotic-free strategies are also introduced. Current challenges in this field and future perspectives are presented to stimulate new technologies and their translation to fight against bacterial infection.

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Section: Nanomaterials For Antibiotic‐free Antibacterial Applicationsmentioning

confidence: 99%

Antibiotic‐Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives

et al. 2019

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“…As we mentioned above, pH responsiveness is featured by the reversible pronation/deprotonation of a specific chemical group, inducing the change of its charge or solubility. Therefore, there are two major strategies in designing pH‐responsive drug‐delivery systems . On one hand, the pH‐responsive moieties could be located on the shells of the nanocarriers to form the surface‐adaptive nanocarriers.…”

Section: Adaptive Antimicrobial‐delivery Systemsmentioning

confidence: 99%

“…The development of new antibiotics is largely hurdled by the rapid emergence of drug‐resistant bacteria, and nowadays, few pharmaceutical companies are willing to invest huge research and development costs to develop new antibiotics. Other than planktonic mode of growth, in most cases, bacteria are prone to attach to the surfaces of tissues or implants, producing extracellular polymeric substances (EPS) to form the notorious biofilms . Additionally, in some extreme cases, invaded bacteria could be internalized by mammalian cells, while once inside cells, bacteria camouflage themselves to avoid the clearance of the infected cells ( Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

“…With rational design, adaptive materials are able to eradicate bacteria in a “contact and kill” manner, which is also efficient to eradicate the multidrug‐resistant bacteria . Moreover, adaptive nanocarriers can deliver antimicrobials to overcome the barriers of biofilms and cells, enhance the efficacy of conventional antimicrobial, and reduce their dose of antimicrobials as well as the likelihood of pathogens being resistant to antimicrobials . This feature article highlights the recent developments of the adaptive materials used in detecting and combating pathogenic bacteria, mainly in their biofilm mode or intracellular mode of growth.…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances and Future Prospects on Adaptive Biomaterials for Antimicrobial Applications

Liu

et al. 2019

Macromolecular Bioscience

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Bacterial infection is becoming the biggest threat to human health. The scenario is partly due to the ineffectiveness of the conventional antibiotic treatments against the emergence of multidrug‐resistant bacteria and partly due to the bacteria living in biofilms or cells. Adaptive biomaterials can change their physicochemical properties in the microenvironment of bacterial infection, thereby facilitating either their interactions with bacteria or drug release. The trends in treating bacterial infections using adaptive biomaterials‐based systems are flourishing and generate innumerous possibility to design novel antimicrobial therapeutics. This feature article aims to summarize the recent developments in the formulations, mechanisms, and advances of adaptive materials in bacterial infection diagnosis, contact killing of bacteria, and antimicrobial drug delivery. Also, the challenges and limitations of current antimicrobial treatments based on adaptive materials and their clinical and industrial future prospects are discussed.

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“…To counter the increasing threat of bacterial infections, numerous nanotechnology-based antimicrobials and smart, antimicrobial-delivery nanocarriers are being designed (Liu et al, 2019a), such as carbon quantum dots, graphene, gold, silver, iron oxide, or polymeric nanoparticles, including micelles or antimicrobial dendrimers. However, the antimicrobial efficacy of many new nanoparticles are insignificant for clinical usage and only achieve about 90% reductions in bacterial viability (1 log unit), while a minimum of 99.9-99.99% (3-4 log units) is required to achieve any clinical efficacy (Liu X. et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Applications and Perspectives of Cascade Reactions in Bacterial Infection Control

Yang

Ren

et al. 2020

Front. Chem.

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Cascade reactions integrate two or more reactions, of which each subsequent reaction can only start when the previous reaction step is completed. Employing natural substrates in the human body such as glucose and oxygen, cascade reactions can generate reactive oxygen species (ROS) to kill tumor cells, but cascade reactions may also have potential as a direly needed, novel bacterial infection-control strategy. ROS can disintegrate the EPS matrix of infectious biofilm, disrupt bacterial cell membranes, and damage intra-cellular DNA. Application of cascade reactions producing ROS as a new infection-control strategy is still in its infancy. The main advantages for infection-control cascade reactions include the fact that they are non-antibiotic based and induction of ROS resistance is unlikely. However, the amount of ROS generated is generally low and antimicrobial efficacies reported are still far <3-4 log units necessary for clinical efficacy. Increasing the amounts of ROS generated by adding more substrate bears the risk of collateral damage to tissue surrounding an infection site. Collateral tissue damage upon increasing substrate concentrations may be prevented by locally increasing substrate concentrations, for instance, using smart nanocarriers. Smart, pH-responsive nanocarriers can self-target and accumulate in infectious biofilms from the blood circulation to confine ROS production inside the biofilm to yield long-term presence of ROS, despite the short lifetime (nanoseconds) of individual ROS molecules. Increasing bacterial killing efficacies using cascade reaction components containing nanocarriers constitutes a first, major challenge in the development of infection-control cascade reactions. Nevertheless, their use in combination with clinical antibiotic treatment may already yield synergistic effects, but this remains to be established for cascade reactions. Furthermore, specific patient groups possessing elevated levels of endogenous substrate (for instance, diabetic or cancer patients) may benefit from the use of cascade reaction components containing nanocarriers.

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Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control

Abstract: Bacterial-infections are mostly due to bacteria in their biofilm-mode of growth. Nanotechnology-based antimicrobials possess excellent potential in biofilm-infection control, overcoming the biological barriers of biofilms.

Cited by 517 publications

References 53 publications

Antibiotic‐Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives

Antibiotic‐Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives

Recent Advances and Future Prospects on Adaptive Biomaterials for Antimicrobial Applications

Applications and Perspectives of Cascade Reactions in Bacterial Infection Control

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