Nanotechnology Approaches in Chronic Wound Healing

Blanco-Fernandez, Bárbara; Castaño, Óscar; Mateos‐Timoneda, Miguel A.; Engel, Elisabeth; Pérez‐Amodio, Soledad

doi:10.1089/wound.2019.1094

Cited by 105 publications

(86 citation statements)

References 153 publications

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“…In addition, several nanocarriers can be endowed with an inherent antimicrobial activity, thus synergizing with the antimicrobial efficacy of a coupled antibiotic [21]. All these findings appear extremely intriguing, since they may be exploited to produce innovative and nonconventional nanotherapies for wound management [22,23].…”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of Different Chitosan Species and Derivatives as Candidate Biomaterials for Oxygen-Loaded Nanodroplet Formulations to Treat Chronic Wounds

et al. 2021

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Persistent hypoxia is a main clinical feature of chronic wounds. Intriguingly, oxygen-loaded nanodroplets (OLNDs), filled with oxygen-solving 2H,3H-decafluoropentane and shelled with polysaccharides, have been proposed as a promising tool to counteract hypoxia by releasing a clinically relevant oxygen amount in a time-sustained manner. Here, four different types of chitosan (low or medium weight (LW or MW), glycol-(G-), and methylglycol-(MG-) chitosan) were compared as candidate biopolymers for shell manufacturing. The aim of the work was to design OLND formulations with optimized physico-chemical characteristics, efficacy in oxygen release, and biocompatibility. All OLND formulations displayed spherical morphology, cationic surfaces, ≤500 nm diameters (with LW chitosan-shelled OLNDs being the smallest), high stability, good oxygen encapsulation efficiency, and prolonged oxygen release kinetics. Upon cellular internalization, LW, MW, and G-chitosan-shelled nanodroplets did not significantly affect the viability, health, or metabolic activity of human keratinocytes (HaCaT cell line). On the contrary, MG-chitosan-shelled nanodroplets showed very poor biocompatibility. Combining the physico-chemical and the biological results obtained, LW chitosan emerges as the best candidate biopolymer for future OLND application as a skin device to treat chronic wounds.

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Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of Different Chitosan Species and Derivatives as Candidate Biomaterials for Oxygen-Loaded Nanodroplet Formulations to Treat Chronic Wounds

et al. 2021

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“…Reduction of silver to silver nanoparticles was visually observed by color change from yellowish orange to dark brown color in Figure 2 showing the synthesis of silver nanoparticles.. Gelatin 9 was mixed well with aloe vera gel and glycerin to obtain a translucent solution named as gel base. Addition of silver nanoparticles to gel solution resulted in BioFibGel as the final product with slight color change to the gel matrix.…”

Section: Resultsmentioning

confidence: 99%

BioFibGel: A Green Nanotechnology Based Wound Dressing

Shandilya¹,

Tarwadi²,

Chavan³

et al. 2021

IJPER

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Aim: Wound is a fragile and complex injury which can be as simple as a minor cut to the deep lesions and traumatic gash. Depending on the patient's internal and external conditions, wounds can progress backward or forward. Acute hemorrhage and wound infections are the main cause of loss of life in critical conditions of war field or in traumatic accidents. Innovation: BioFibGel bandage/dressing is a green nanotechnology based wound care product which is intended to be used in trauma, combat injuries (bleeding gunshot wounds) and mangling as first-line emergency tool. The dressing can absorb and retain significant amount of water without dissolving or losing their structure, stabilize blood flow and avert bleeding. Materials and Results: BioFibGel is silver nanoparticles based hydrogel sheets/ fibers made up of gelatin, glycerin and aloe vera which are considered as ideal materials for hemostasis activities and encourages cleaning and protection from reinjures or infection and speeds wound healing along with real-time monitoring of pH of wound using carbon dots fluorescence. Conclusion: This work is an attempt to devise a wound dressing that can aid in natural blood-clotting mechanism (sparing blood loss) and providing positive environment in wound healing.

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“…The nanoparticles have been extensively used for wound healing, which may have different functions such as anti-infection, antioxidant, immunoregulation, and controlled release of drugs/cytokines/genes [ 220 ]. Qiao et al prepared copper sulfide nanodots that can eradicate multidrug-resistant bacteria owing to the photothermal effect [ 221 ].…”

Section: Chronic Inflammation-associated Diseases and Therapiesmentioning

confidence: 99%

The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials

et al. 2021

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Tissue regeneration is an active multiplex process involving the dynamic inflammatory microenvironment. Under a normal physiological framework, inflammation is necessary for the systematic immunity including tissue repair and regeneration as well as returning to homeostasis. Inflammatory cellular response and metabolic mechanisms play key roles in the well-orchestrated tissue regeneration. If this response is dysregulated, it becomes chronic, which in turn causes progressive fibrosis, improper repair, and autoimmune disorders, ultimately leading to organ failure and death. Therefore, understanding of the complex inflammatory multiple player responses and their cellular metabolisms facilitates the latest insights and brings novel therapeutic methods for early diseases and modern health challenges. This review discusses the recent advances in molecular interactions of immune cells, controlled shift of pro- to anti-inflammation, reparative inflammatory metabolisms in tissue regeneration, controlling of an unfavorable microenvironment, dysregulated inflammatory diseases, and emerging therapeutic strategies including the use of biomaterials, which expand therapeutic views and briefly denote important gaps that are still prevailing.

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Nanotechnology Approaches in Chronic Wound Healing

Cited by 105 publications

References 153 publications

Comparative Evaluation of Different Chitosan Species and Derivatives as Candidate Biomaterials for Oxygen-Loaded Nanodroplet Formulations to Treat Chronic Wounds

Comparative Evaluation of Different Chitosan Species and Derivatives as Candidate Biomaterials for Oxygen-Loaded Nanodroplet Formulations to Treat Chronic Wounds

BioFibGel: A Green Nanotechnology Based Wound Dressing

The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials

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