Nanotechnology approaches for skin wound regeneration using drug-delivery systems

García-Orue, Itxaso; Gainza, Garazi; Villullas, Silvia; Pedraz, José Luís; Hernández, Rosa María; Igartua, Manoli

doi:10.1016/b978-0-323-42865-1.00002-7

Cited by 13 publications

(9 citation statements)

References 87 publications

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“…Granulation is defined as the promotion of tissue granulation by fibroblasts, granulocytes and macrophages. Finally, remodeling involves the production of collagen-and elastin-including fibroblasts leading to myofibroblasts in the presence of T cells and macrophages [106]. Monocyte chemoattractant protein 1, cytokines (interlukin-1 and interlukin-6), growth factors such as fibroblast growth factor (FGF), epidermal growth factor (EGF), transforming growth factor-β (TGF-β), platelet-derived growth factor (PDGF), bone morphogenic proteins (BMPs), connective tissue growth factor (CTGF), granulocyte macrophage-colony stimulating factor (GM-CSF) and vascular endothelial growth factor (VEGF) participate in wound healing.…”

Section: Nanoparticlesmentioning

confidence: 99%

“…Decreased blood supply to the wound leads to ulcer formation. There are four phases in wound healing, namely, hemostasis, inflammation, proliferation and remodeling ( Figure 4 ) [ 106 ].…”

Section: Wounds and The Barriers For Topical Drug Delivery To Wounmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Evolution of Nanotechnology in Delivering Drugs to Eyes, Skin and Wounds via Topical Route

et al. 2020

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The topical route is the most preferred one for administering drugs to eyes, skin and wounds for reaching enhanced efficacy and to improve patient compliance. Topical administration of drugs via conventional dosage forms such as solutions, creams and so forth to the eyes is associated with very low bioavailability (less than 5%) and hence, we cannot rely on these for delivering drugs to eyes more efficiently. An intravitreal injection is another popular drug delivery regime but is associated with complications like intravitreal hemorrhage, retinal detachment, endophthalmitis, and cataracts. The skin has a complex structure that serves as numerous physiological barriers to the entry of exogenous substances. Drug localization is an important aspect of some dermal diseases and requires directed delivery of the active substance to the diseased cells, which is challenging with current approaches. Existing therapies used for wound healing are costly, and they involve long-lasting treatments with 70% chance of recurrence of ulcers. Nanotechnology is a novel and highly potential technology for designing formulations that would improve the efficiency of delivering drugs via the topical route. This review involves a discussion about how nanotechnology-driven drug delivery systems have evolved, and their potential in overcoming the natural barriers for delivering drugs to eyes, skin and wounds.

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Section: Nanoparticlesmentioning

confidence: 99%

“…Decreased blood supply to the wound leads to ulcer formation. There are four phases in wound healing, namely, hemostasis, inflammation, proliferation and remodeling ( Figure 4 ) [ 106 ].…”

Section: Wounds and The Barriers For Topical Drug Delivery To Wounmentioning

confidence: 99%

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Evolution of Nanotechnology in Delivering Drugs to Eyes, Skin and Wounds via Topical Route

et al. 2020

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“…There are a number of different nanoparticle strategies in development for the delivery of therapeutic molecules into the wound site, with benefits such as controlled and targeted drug delivery, protection of molecules from degradation, decreased toxicity, and easy integration with other wound healing techniques [68,75]. Nanoparticle types include micelles, selfassembled core-shell structures; polymeric nanoparticles composed of biodegradable polymers; nanoemulsions, nanometric droplets dispersed into another immiscible liquid; liposomes, spherical lipid bilayer structures; cyclodextrins, hollow particles of cyclic oligosaccharides from glucopyranose; and inorganic nanoparticles, composed of metals [68•].…”

Section: Nanomaterialsmentioning

confidence: 99%

Development of Novel Microenvironments for Promoting Enhanced Wound Healing

Scull

Brown

2020

Curr. Tissue Microenviron. Rep.

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Purpose of Review Non-healing wounds are a significant issue facing the healthcare industry. Materials that modulate the wound microenvironment have the potential to improve healing outcomes. Recent Findings A variety of acellular and cellular scaffolds have been developed for regulating the wound microenvironment, including materials for controlled release of antimicrobials and growth factors, materials with inherent immunomodulative properties, and novel colloidal-based scaffolds. Scaffold construction methods include electrospinning, 3D printing, decellularization of the extracellular matrix, or a combination of techniques. Material application methods include layering or injecting at the wound site. Summary Though these techniques show promise for repairing wounds, all material strategies thus far struggle to induce regeneration of features such as sweat glands and hair follicles. Nonetheless, innovative technologies currently in the research phase may facilitate future attainment of these features. Novel methods and materials are constantly arising for the development of microenvironments for enhanced wound healing. Keywords Wound microenvironment. Wound modulation. Chronic wounds. Biomaterials. Biomaterials for wound healing. Novel wound healing materials This article is part of the Topical Collection on Cell Behavior Manipulation

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“…The probabilities of occurring of cutaneous wounds are more, as skin is vulnerable to a variety of external factors and resulting in different types of skin damage. The available traditional therapies generally involve high cost and long-lasting treatments with an ulcer relapse rate of above 70 % [7]. Significant efforts have been made towards wound care management in recent years for framing the new therapeutic approaches and technologies, however,satisfactory results have still not been achieved.…”

Section: Introductionmentioning

confidence: 99%

Comparative evaluation for wound healing potentials of bulk and nano forms of zinc oxide ointment

Gupta¹,

Verma²,

Gupta³

et al. 2020

Nanosystems: Phys. Chem. Math.

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Development of nanotechnology has led to massive breakthroughs in the area of wound healing. Recently, metal oxide nanoparticles have shown a broad range of applications in biomedical fields. The lack of potent healing agents for complicated wounds and healing potentials of zinc oxide (ZnO) motivated us to evaluate the wound healing potentials of nano ZnO in comparison to its bulk form in rats. In the present study, single open excision wounds (2 × 2 cm 2) were created on the backs of fifteen rats and divided into Group I, II and III. On the wounds of group I, II and III, topical application of ointment base, bulk ZnO (20 %) and ZnO nanoparticles (2 %) was done for 14 days, respectively. Significantly smaller wound area and increased percent wound contraction was evident in the ZnO nanoparticles-treated group. Histopathological analysis revealed that the ZnO nanoparticle-treated wounds possessed reduced numbers of fibroblasts and blood vessels. However, collagen fibers in ZnO treated group were compactly arranged in thick bundles with a well-organized manner and orientation. The newly formed epithelial layer was also covering more area of healing tissue in the ZnO nanoparticle-treated group. The ZnO nanoparticle-treated group also revealed the higher overall wound maturity score, as compared to other groups. In view of this, it might be concluded that topical application of ZnO nanoparticles (2 %) caused faster wound healing and the healing was better than bulk ZnO treatment, even at tenfold lower concentration.

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Nanotechnology approaches for skin wound regeneration using drug-delivery systems

Cited by 13 publications

References 87 publications

Evolution of Nanotechnology in Delivering Drugs to Eyes, Skin and Wounds via Topical Route

Evolution of Nanotechnology in Delivering Drugs to Eyes, Skin and Wounds via Topical Route

Development of Novel Microenvironments for Promoting Enhanced Wound Healing

Comparative evaluation for wound healing potentials of bulk and nano forms of zinc oxide ointment

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