2021
DOI: 10.1007/s13346-021-00965-y
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Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control

Abstract: The COVID-19 pandemic's high mortality rate and severe socioeconomic impact serve as a reminder of the urgent need for effective countermeasures against viral pandemic threats. In particular, effective antiviral therapeutics capable of stopping infections in its tracks is critical to reducing infection fatality rate and healthcare burden. With the field of drug delivery witnessing tremendous advancement in the last two decades owing to a panoply of nanotechnology advances, the present review summarizes and exp… Show more

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Cited by 24 publications
(15 citation statements)
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“…The described nanomaterials can be categorized according to their chemistry; inorganic and organic materials as the base material. Organic materials include carriers based on polymers and lipids like dendrimers, liposomes, dendrimers and other polymer derivatives, while inorganic materials include materials like metal-based nanomaterials and carbon-based nanomaterials (fullerenes, graphene, graphene oxide) [ 154 , 155 ]. These nanomaterials are functionalized for their use as drug carriers, depending on the different physical and chemical parameters [ 156 ].…”
Section: Viral Capsids and Other Nanomaterials As Drug Carriersmentioning
confidence: 99%
“…The described nanomaterials can be categorized according to their chemistry; inorganic and organic materials as the base material. Organic materials include carriers based on polymers and lipids like dendrimers, liposomes, dendrimers and other polymer derivatives, while inorganic materials include materials like metal-based nanomaterials and carbon-based nanomaterials (fullerenes, graphene, graphene oxide) [ 154 , 155 ]. These nanomaterials are functionalized for their use as drug carriers, depending on the different physical and chemical parameters [ 156 ].…”
Section: Viral Capsids and Other Nanomaterials As Drug Carriersmentioning
confidence: 99%
“…Lactoferrin of a multifunctional glycoprotein is currently being developed in the treatment of SARS-CoV-2. Lactoferrin liposome shows promising results by inhibiting the entry of viruses, reducing inflammation [52] and having the activities as an immunomodulator. Lactoferrin liposomes will be related to ACE-2 so that SARS-CoV-2 will not interact with ACE-2, which causes it to not be able to enter the host cell.…”
Section: Liposomementioning
confidence: 99%
“…Drug delivery systems (DDSs), employing nanoformulations, have been the main platform of nanomedicine over the last few decades, witnessing tremendous advancements in therapy against various infectious by viruses (i.e., HIV, influenza, coronaviruses) and bacteria [4][5][6][7]. The main concept behind using nano-antivirals is to allow nanoparticle (NP)-virus interactions, based on the small size of the virus, offering a realistic solution for treating them.…”
Section: Introductionmentioning
confidence: 99%
“…The natural prodrug ELG (2,3,7,8-tetrahydroxy-chromeno [5,4,3-cde]chromene-5,10dione), a safe and powerful polyphenol, is present in several types of fruit (e.g., grapes, pomegranates, strawberries, and walnuts) [20,21] and medicinal plants [22]. It exhibits multiple pharmacological actions, including anticancer, antiviral, anti-inflammatory, and antimicrobial effects [21,23,24].…”
Section: Introductionmentioning
confidence: 99%