Nanotechnological Applications Hold a Pivotal Position in Boosting Stem Cells Osteogenic Activity: In Vitro and In Vivo Studies

Evaluation of the Efficacy of Stem Cell Therapy in Ovariectomized Osteoporotic Rats Based on Micro-CT and Dual-Energy X-Ray Absorptiometry: A Systematic Review and Meta-Analysis

“…Characteristics of the Included Studies. A total of 10 RCTs and 3 non-RCTs involving 405 rats were included in this meta-analysis, all published from 2008 to 2020 [9][10][11][12][13][14][15][16][17][18][19][20][21]. All included studies explored the efficacy of stem cell transplantation in OVX osteoporotic rats.…”

“…All included studies explored the efficacy of stem cell transplantation in OVX osteoporotic rats. There are 4 sources of stem cells in the included studies, of which 8 studies are BMSCs [9,10,13,14,[17][18][19]21], 3 studies are ADSCs [11,15,16], one study is AM-MSCs [12], and the remaining 1 study is hUCB-MSCs [20]. Female rats were used in all 13 included studies, 11 of which were Sprague Dawley (SD) rats [9-11, 13-18, 20, 21] and 2 of which were Wistar rats [12,19].…”

“…Stem cell transplantation is proposed as a potential treatment strategy for patients with osteoporosis [8]. Some experimental studies have been conducted in animal models of osteoporosis to evaluate the therapeutic effect of stem cell transplantation [8][9][10][11][12][13][14][15][16][17][18][19][20][21]. Stem cells used in animal models of osteoporosis include bone marrow mesenchymal stem cells (BMSCs) [21], adipose-derived stem cells (ADSCs) [16], amniotic membrane mesenchymal stem cells (AM-MSCs) [12], and human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) [20].…”

“…Stem cells used in animal models of osteoporosis include bone marrow mesenchymal stem cells (BMSCs) [21], adipose-derived stem cells (ADSCs) [16], amniotic membrane mesenchymal stem cells (AM-MSCs) [12], and human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) [20]. Among them, BMSCs are able to differentiate into multiple cell types, including osteoblasts, chondrocytes, and adipocytes, under appropriate culture conditions and are the most commonly used MSC for osteoporosis due to their easy accessibility and strong osteogenic differentiation [4,19]. Some of the current experimental studies evaluated the potential therapeutic effects of stem cell transplantation in OVX osteoporotic rats by using micro-CT and dual-energy X-ray absorptiometry [9][10][11][12][13][14][15][16][17][18][19][20][21].…”

“…Among them, BMSCs are able to differentiate into multiple cell types, including osteoblasts, chondrocytes, and adipocytes, under appropriate culture conditions and are the most commonly used MSC for osteoporosis due to their easy accessibility and strong osteogenic differentiation [4,19]. Some of the current experimental studies evaluated the potential therapeutic effects of stem cell transplantation in OVX osteoporotic rats by using micro-CT and dual-energy X-ray absorptiometry [9][10][11][12][13][14][15][16][17][18][19][20][21]. In order to investigate the potential efficacy of stem cell transplantation in OVX osteoporotic rats and thus provide some support for the possibility of stem cell transplantation in the treatment of osteoporosis, we constructed this meta-analysis by pooling the relevant studies mentioned above.…”