Nanosystem trends in drug delivery using quality-by-design concept

Li, Jing; Qiao, Yanjiang; Wu, Zhisheng

doi:10.1016/j.jconrel.2017.04.019

Cited by 77 publications

(50 citation statements)

References 143 publications

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“…Applying concepts of quality by design, such as process analytical technologies (PAT), will ensure an on line/at line quality assessment approach. 113,114 …”

Section: Risk Assessment and Control Bandingmentioning

confidence: 99%

Nanoparticles in Daily Life: Applications, Toxicity and Regulations

Gupta

Xie

2018

J Environ Pathol Toxicol Oncol

397

188

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At nanoscale, man-made materials may show unique properties that differ from bulk and dissolved counterparts. The unique properties of engineered nanomaterials not only impart critical advantages but also confer toxicity because of their unwanted interactions with different biological compartments and cellular processes. In this review, we discuss various entry routes of nanomaterials in the human body, their applications in daily life, and the mechanisms underlying their toxicity. We further explore the passage of nanomaterials into air, water, and soil ecosystems, resulting in diverse environmental impacts. Briefly, we probe the available strategies for risk assessment and risk management to assist in reducing the occupational risks of potentially hazardous engineered nanomaterials including the control banding (CB) approach. Moreover, we substantiate the need for uniform guidelines for systematic analysis of nanomaterial toxicity, in silico toxicological investigations, and obligation to ensure the safe disposal of nanowaste to reduce or eliminate untoward environmental and health impacts. At the end, we scrutinize global regulatory trends, hurdles, and efforts to develop better regulatory sciences in the field of nanomedicines.

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“…Applying concepts of quality by design, such as process analytical technologies (PAT), will ensure an on line/at line quality assessment approach. 113,114 …”

Section: Risk Assessment and Control Bandingmentioning

confidence: 99%

Nanoparticles in Daily Life: Applications, Toxicity and Regulations

Gupta

Xie

2018

J Environ Pathol Toxicol Oncol

397

188

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“…10,16 Liposomes, polymer micelles/ microspheres, dendrimers, nanocapsules, and metal nanoparticles have been used as vehicles for drug delivery and bioregulation. [21][22][23] Nano-or micro-scale hydroxyapatite (HA) particles measure in the order of hundreds of nanometers in length and have been widely used in bone reconstruction. In contrast to plate-shaped bone apatite, HA particles are rod-shaped and appear as enamel.…”

Section: Introductionmentioning

confidence: 99%

Strontium ranelate-loaded PLGA porous microspheres enhancing the osteogenesis of MC3T3-E1 cells

et al. 2017

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“…This demonstrates evidence of the relevance of interactions between the factors and highlights the significant effects on a statistically sound basis [19,20]. Some papers are present in the literature using DoE in the development of nanomedicines [21] and more specifically of polymeric micelles. Some of them refer to systems based on poloxamers [22,23], and in a few cases, HA-based polymeric micelles have been developed [24].…”

Section: Introductionmentioning

confidence: 76%

Design of Experiments-Assisted Development of Clotrimazole-Loaded Ionic Polymeric Micelles Based on Hyaluronic Acid

et al. 2020

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Polymeric micelles based on amphiphilic polysaccharides have some advantages as a carrier of poorly soluble lipophilic drugs thanks to their characteristic "core–shell" structure. Previously, ionic polymeric micelles based on chitosan and fatty acids have been developed. The aim of the present study was the preparation and characterization of hyaluronic acid (HA) derivatives by direct ionic interaction between the HA carboxylic groups and the amine groups of dodecyl amine (DDA) and hexadecyl amine (HDA). The HA–HDA polymeric micelles were loaded with a poorly soluble hydrophobic antifungal drug, clotrimazole (CLO). A 23 full factorial experimental design was used to evaluate the effect of the following factors: HA/HDA ratio from 1:0.25 to 1:0.75, cholesterol (CHOL%) as percentage of HA from 10% to 30%, and preparation temperature from 20 to 40 °C. As dependent variables (responses), nanoparticle dimensions and clotrimazole concentration in the final colloidal dispersion were considered. To optimize the drug final concentration, the design was therefore expanded into a rotatable central composite design (CCD). The effects of the formulation variables and the composition of the optimized formulation were confirmed by a mixture design. Physicochemical characterization of the optimized formulation was performed, confirming the ionic interaction between the polysaccharide and the HDA.

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Nanosystem trends in drug delivery using quality-by-design concept

Cited by 77 publications

References 143 publications

Nanoparticles in Daily Life: Applications, Toxicity and Regulations

Nanoparticles in Daily Life: Applications, Toxicity and Regulations

Strontium ranelate-loaded PLGA porous microspheres enhancing the osteogenesis of MC3T3-E1 cells

Design of Experiments-Assisted Development of Clotrimazole-Loaded Ionic Polymeric Micelles Based on Hyaluronic Acid

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