Nanosuspension Technologies for Delivery of Poorly Soluble Drugs-A Review

Patel, Harshil; Patel, Bhumi B.; Shah, Chainesh N.; Shah, Dhiren P.

doi:10.5958/0974-360x.2016.00120.7

Cited by 20 publications

(6 citation statements)

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“…Many of the new drugs, especially among phytopharmaceuticals, are poorly water-soluble and hence have low bioavailability. 1 Resveratrol is hydrophobic (solubility <0.05 mg/ mL), undergoes fast metabolization in the intestines and liver, 2 and is also a highly reactive and therefore unstable molecule owing to the presence of OH-groups, benzene rings, and C=C bonds. 3 Resveratrol is stable in acidic conditions but starts to degrade exponentially above pH 6.8, reaching maximum degradation at pH 9.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of innovative resveratrol nanobelt-like particles and assessment of their bioactivity, antioxidative and antibacterial properties

Tomić

Matić²,

Filipović

et al. 2023

J Biomater Appl

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Recently, many studies have shown various beneficial effects of polyphenol resveratrol (Res) on human health. The most important of these effects include cardioprotective, neuroprotective, anti-cancer, anti-inflammatory, osteoinductive, and anti-microbial effects. Resveratrol has cis and trans isoforms, with the trans isoform being more stable and biologically active. Despite the results of in vitro experiments, resveratrol has limited potential for application in vivo due to its poor water solubility, sensitivity to oxygen, light, and heat, rapid metabolism, and therefore low bioavailability. The possible solution to overcome these limitations could be the synthesis of resveratrol in nanoparticle form. Accordingly, in this study, we have developed a simple, green solvent/non-solvent physicochemical method to synthesize stable, uniform, carrier-free resveratrol nanobelt-like particles (ResNPs) for applications in tissue engineering. UV–visible spectroscopy (UV-Vis) was used to identify the trans isoform of ResNPs which remained stable for at least 63 days. The additional qualitative analysis was performed by Fourier transform infrared spectroscopy (FTIR), while X-ray diffraction (XRD) determined the monoclinic structure of resveratrol with a significant difference in the intensity of diffraction peaks between commercial and nano-belt form. The morphology of ResNPs was evaluated by optical microscopy and field-emission scanning electron microscope (FE-SEM) that revealed a uniform nanobelt-like structure with an individual thickness of less than 1 μm. Bioactivity was confirmed using Artemia salina in vivo toxicity assay, while 2,2–diphenyl-1-picrylhydrazylhydrate (DPPH) reduction assay showed the good antioxidative potential of concentrations of 100 μg/ml and lower. Microdilution assay on several reference strains and clinical isolates showed promising antibacterial potential on Staphylococci, with minimal inhibitory concentration (MIC) being 800 μg/ml. Bioactive glass-based scaffolds were coated with ResNPs and characterized to confirm coating potential. All of the above make these particles a promising bioactive, easy-to-handle component in various biomaterial formulations.

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of innovative resveratrol nanobelt-like particles and assessment of their bioactivity, antioxidative and antibacterial properties

Tomić

Matić²,

Filipović

et al. 2023

J Biomater Appl

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“…4 1.1 Nano Suspension Advantages 1) Reduced tissue irritation in the case of subcutaneous/intramuscular administration 2) Enhanced dissolution rate and saturation solubility of the drug. 5 3) Long-term physical firmness. 4) Higher drug loading can be attained.…”

Section: Introductionmentioning

confidence: 99%

Nanosuspension as Promising and Potential Drug Delivery: A Review

Chinthaginjala¹,

Ahad²,

Reddy³

et al. 2022

Int J Life Sci Pharm Res

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In the last decade, nanosuspensions have gained considerable interest as a method for formulating poorly soluble drugs. Because of their cost-effectiveness and technological simplicity compared to liposomes and other colloidal drug carriers, nanoscale systems have recently received a lot of attention as a way of solving problems of solubility. Nanosuspensions are biphasic systems comprising of pure drug particles dispersed in an aqueous vehicle, stabilized by surface active agents. Fabrication of nanosuspension is simple and more advantageous than other approaches. Nanosuspension is a very finely single solid drug particle in an aqueous vessel, stabilized by surfactants for either oral or topical use or for parenteral and pulmonary administration, it can also be used for targeted drug delivery when incorporated in the ocular inserts and mucoadhesive hydrogels, with reduced particle size resulting in increased dissolution rate. This article covers the preparation of nanosuspension by bottom up technology, top down technology, melt emulsification, emulsification- solvent evaporation and supercritical fluid with their advantages and disadvantages, aspects of structure, classification and their drug delivery applications. Nanosuspension can be processed for the drugs which are of hydrophobic in nature quite easily employing stability enhancers, solvents that are of organic and additional ingredients including buffering agents, salts, PEG, osmotic agents and anti-freeze compounds.

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“…Este cenário tem impulsionado pesquisas com o objetivo de melhorar e/ou complementar a ação dos fármacos existentes, bem como avaliar novos candidatos a fármacos. Problemas como baixa solubilidade e baixa biodisponibilidade têm sido minimizados através, respectivamente, da incorporação das amostras em polímeros solúveis em água, como a polivinilpirrolidona (PVP) e o polietileno glicol (PEG), a administração do fármaco incorporado em lipossomas, a utilização da β-ciclodextrina como carreador do fármaco e ainda nanopartículas poliméricas (EL-LAKKANY et al, 2012;FREZZA et al, 2013a;LEUNER & DRESSMAN, 2000;MAINARDES et al, 2006;PATEL et al, 2012;SILVA et al, 2012;VASCONCELOS et al, 2007;YU et al, 2009).…”

Section: Abreviaturasunclassified

“…Estudos demonstraram que o PZQ era bem tolerado por pacientes de todas as idades e com diferentes formas clínicas, incluindo casos hepatoesplênicos e apresentava efeitos colaterais brandos além de não ser mutagênico (BASSILY et al, 1985;FROHBERG, 1984;MONTERO & OSTROSKY, 1997). Além disso, é administrado por via oral em dose única, o que oferece uma série de vantagens como facilidade na administração, estabilidade, dosagem exata e fácil produção (PATEL et al, 2012).…”

Section: A Quimioterapia Da Esquistossomose Mansônicaunclassified

“…Embora , 2012;LEOPOLD et al, 1978;PATEL et al, 2012;SILVA et al, 2012;THÉTIOT-LAURENT et al, 2013;VALENCIA et al, 1994). Estas limitações têm impulsionado pesquisas visando ampliar o espectro de ação do PZQ através de quimioterapia conjugada com substâncias sintéticas, semisintéticas e naturais (MACIEL et al, 2002;DEL VILLAR et al, 2012).…”

Section: A Quimioterapia Da Esquistossomose Mansônicaunclassified

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Efeito da atividade de derivados da artemisinina sobre a linhagem SE de Schistosoma mansoni

Corrêa¹,

Allegretti²

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Ao meu esposo Robson Corrêa e aos meus filhos Gabriel, Luigi e Nicole. Vocês foram meu alicerce nesta difícil aventura! Obrigada pelo amor, compreensão e incentivo! Amo muito cada um de vocês! Agradecimentos A Deus, pelo dom da vida, por ter me dado a graça de fazer parte desta família chamada UNICAMP e por ter me sustentado em meio às provações e dificuldades vividas neste tempo. À Profa. Dra. Silmara Marques Allegretti, pela confiança depositada em mim! Obrigada pelo carinho, compreensão e orientação. Você foi e será sempre para mim muito mais que uma orientadora, uma amiga! À Profa. Dra. Verônica de Lourdes Sierpe Jeraldo, obrigada pelo apoio e orientação! Aos membros da banca examinadora, Profa.

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Nanosuspension Technologies for Delivery of Poorly Soluble Drugs-A Review

Cited by 20 publications

References 0 publications

Synthesis and characterization of innovative resveratrol nanobelt-like particles and assessment of their bioactivity, antioxidative and antibacterial properties

Synthesis and characterization of innovative resveratrol nanobelt-like particles and assessment of their bioactivity, antioxidative and antibacterial properties

Nanosuspension as Promising and Potential Drug Delivery: A Review

Efeito da atividade de derivados da artemisinina sobre a linhagem SE de Schistosoma mansoni

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