Nanostructured titanium surfaces fabricated by hydrothermal method: Influence of alkali conditions on the osteogenic performance of implants

Huang, Y.; He, Shu-Kun; Guo, Zhijun; Pi, Jin-Kui; Deng, Li; Dong, Li Hua; Zeng, Yi; Su, Bo; Da, Lincui; Zhang, Li; Xiang, Zhou; Ding, Wei; Gong, Maolian; Xie, Huiqi

doi:10.1016/j.msec.2018.08.069

Cited by 40 publications

(32 citation statements)

References 59 publications

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“…The hydrothermal method has been proved to be a facile and cost-effective approach to obtain nanostructured titanate layers on Ti surfaces under relatively high pressure and temperature [21]. The composition of nanostructured titanate layers on Ti surfaces is H 2 Ti 2 O 5 ∙H 2 O and Na 2 Ti 2 O 5 ∙H 2 O after hydrothermal method [22]. By changing the concentration of NaOH to 10 mM according to previous studies [23], the surfaces of Ti-NW and Ti-NW-Zn samples in our study were covered with nanowire-like structures.…”

Section: Resultsmentioning

confidence: 99%

Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment

Zhu

Shao

et al. 2019

J Nanobiotechnol

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Titanium (Ti) and its alloys as bio-implants have excellent biocompatibilities and osteogenic properties after modification of chemical composition and topography via various methods. The corrosion resistance of these modified materials is of great importance for changing oral system, while few researches have reported this point. Recently, oxidative corrosion induced by cellular metabolites has been well concerned. In this study, we explored the corrosion behaviors of four common materials (commercially pure Ti, cp-Ti; Sandblasting and acid etching-modified Ti, Ti-SLA; nanowires-modified Ti, Ti-NW; and zinc-containing nanowires-modified Ti, Ti-NW-Zn) with excellent biocompatibilities and osteogenic capacities under the macrophages induced-oxidizing microenvironment. The results showed that the materials immersed into a high oxidizing environment were more vulnerable to corrode. Meanwhile, different surfaces also showed various corrosion susceptibilities under oxidizing condition. Samples embed with zinc element exhibited more excellent corrosion resistance compared with other three surfaces exposure to excessive H 2 O 2 . Besides, we found that zinc-decorated Ti surfaces inhibited the adhesion and proliferation of macrophages on its surface and induced the M2 states of macrophages to better healing and tissue reconstruction. Most importantly, zinc-decorated Ti surfaces markedly increased the expressions of antioxidant enzyme relative genes in macrophages. It improved the oxidation microenvironment around the materials and further protected their properties. In summary, our results demonstrated that Ti-NW-Zn surfaces not only provided excellent corrosion resistance properties, but also inhibited the adhesion of macrophages. These aspects were necessary for maintaining osseointegration capacity and enhancing the corrosion resistance of Ti in numerous medical applications, particularly in dentistry.

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Section: Resultsmentioning

confidence: 99%

Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment

Zhu

Shao

et al. 2019

J Nanobiotechnol

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“…It is known that surface chemical composition and micro/nano structure play important role in regulating the response of the cells. Many previous studies confirmed that either chemical or electrochemical treatments would change the surface composition and structure of Ti-based implants, and thus mediate the behavior of osteoblasts or mesenchymal stem cells (MSCs) [ 26 , 41–44 ]. In current study, the pTi sample without any surface treatment had a relatively smooth surface, which was favorable for the attachment and proliferation of MC3T3-E1 pre-osteoblasts.…”

Section: Resultsmentioning

confidence: 99%

The optimized preparation of HA/L-TiO2/D-TiO2 composite coating on porous titanium and its effect on the behavior osteoblasts

Zhou

Liu

et al. 2020

Regenerative Biomaterials

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Various surface bioactivation technology has been confirmed to improve the osteogenic ability of porous titanium (pTi) implants effectively. In this study, a three-layered composite coating, i.e. outer layer of hydroxyapatite (HA), middle layer of loose titanium dioxide (L-TiO2) and inner layer of dense TiO2 (D-TiO2), was fabricated on pTi by a combined processing procedure of pickling, alkali heat (AH), anodic oxidation (AO), electrochemical deposition (ED) and hydrothermal treatment (HT). After soaking in simulated body fluid for 48 h, the surface of the AHAOEDHT-treated pTi was completely covered by a homogeneous apatite layer. Using MC3T3-E1 pro-osteoblasts as cell model, the cell culture revealed that both the pTi without surface treatment and the AHAOEDHT sample could support the attachment, growth and proliferation of the cells. Compared to the pTi sample, the AHAOEDHT one induced higher expressions of osteogenesis-related genes in the cells, including alkaline phosphatase, Type I collagen, osteopontin, osteoclast inhibitor, osteocalcin and zinc finger structure transcription factor. As thus, besides the good corrosion resistance, the HA/L-TiO2/D-TiO2-coated pTi had good osteogenic activity, showing good potential in practical application for bone defect repair.

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“…Tissue-biomaterial process was a surface phenomena governed by surface properties. From a clinical point of view, ideal bone substitute biomaterial should possess excellent bioactivity and biocompatibility for osteogenesis and osteointegration [15, 30, 34]. Surface modification could add biologically active and compatible functionality onto the bio-inert Ti-based implant surfaces, which improved its osteogenesis and bioactive bone-bonding ability and finally gave rise to favorable bone regeneration and osseointegration.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, osteoblasts, osteoid and minerals could be observed near this kind of interface [14]. The formation of a direct interface was crucial to osseointegration and long-term stability in vivo of implants [34, 36, 37].…”

Section: Resultsmentioning

confidence: 99%

In-vivo performance of plasma-sprayed CaO–MgO–SiO2-based bioactive glass-ceramic coating on Ti–6Al–4V alloy for bone regeneration

Zhang¹,

Pu²,

Chen

et al. 2019

Heliyon

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The CaO–MgO–SiO2-based bioactive glass-ceramic coating (named M2) on Ti–6Al–4V alloy has been proven to behave well in vitro. But how to make full sense of its performances in terms of osteogenesis and osseointegration in vivo matters very much. For this, the M2-coated Ti–6Al–4V cylinders were prepared by atmospheric plasma spraying (APS) and implanted into New Zealand rabbit for 1, 2 and 3 months, respectively, by setting commercial HA-coated Ti–6Al–4V as the control. It is encouraging that, the two groups bonded with the surrounding tissues stably and newly formed bone grew towards or around the implants after 3-month implantation according to radiographic images. From the histological sections, it is obvious that, compared to the control, the M2-coated implant was more favorable for the osteogenesis and neo-vascularisation in the whole experimental process and demonstrated a better osseointegration with the host bone, indicating the former possessed better osteoconductivity, osteoinductivity and osteogenic ability. The study indicated that the M2-coated Ti–6Al–4V implant exerted a great potential to substitute the commercial HA-coated Ti–6Al–4V implant in repairing load-bearing bone defects.

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Nanostructured titanium surfaces fabricated by hydrothermal method: Influence of alkali conditions on the osteogenic performance of implants

Cited by 40 publications

References 59 publications

Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment

Enhanced corrosion resistance of zinc-containing nanowires-modified titanium surface under exposure to oxidizing microenvironment

The optimized preparation of HA/L-TiO2/D-TiO2 composite coating on porous titanium and its effect on the behavior osteoblasts

In-vivo performance of plasma-sprayed CaO–MgO–SiO2-based bioactive glass-ceramic coating on Ti–6Al–4V alloy for bone regeneration

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