Nanostructured Titanium Implant Surface Facilitating Osseointegration from Protein Adsorption to Osteogenesis: The Example of TiO2 NTAs

Wu, Bin; Tang, Yufei; Wang, Kai; Zhou, Xuemei; Xiang, Lin

doi:10.2147/ijn.s362720

Cited by 44 publications

(36 citation statements)

References 120 publications

(179 reference statements)

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“…Specifically, surface energy and hydrophilicity of the NT samples increased after the anodic oxidation process, which plays a critical role in protein adsorption . It is known that changes in surface hydrophobicity and energy can alter the adsorption of proteins and their conformation, which in turn dictate stem cell adhesion and differentiation . For instance, anodized titanium surfaces were shown to be more hydrophilic compared to their NA counterparts, which induced higher fibronectin adsorption and thus allowed higher stem cell adhesion and osteogenic differentiation. , …”

Section: Results and Discussionmentioning

confidence: 99%

Morphology of Nanostructured Tantalum Oxide Controls Stem Cell Differentiation and Improves Corrosion Behavior

Erdogan,

Uslu,

Aydınol

et al. 2023

ACS Biomater. Sci. Eng.

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Tantalum is receiving increasing attention in the biomedical field due to its biocompatible nature and superior mechanical properties. However, the bioinert nature of tantalum still poses a challenge and limits its integration into the bone tissue. To address these issues, we fabricated nanotubular (NT), nanocoral (NC), and nanodimple morphologies on tantalum surfaces via anodization. The size of these nanofeatures was engineered to be approximately 30 nm for all anodized samples. Thus, the influence of the anodized nanostructured morphology on the chemical and biological properties of tantalum was evaluated. The NT and NC samples exhibited higher surface roughness, surface energy, and hydrophilicity compared to the nonanodized samples. In addition, the NT samples exhibited the highest corrosion resistance among all of the investigated samples. Biological experiments indicated that NT and NC samples promoted human adipose tissue-derived mesenchymal stem cell (hADMSC) spreading and proliferation up to 5 days in vitro. ALP, COL1A1, and OSC gene expressions as well as calcium mineral synthesis were upregulated on the NT and NC samples in the second and third weeks in vitro. These findings highlight the significance of nanostructured feature morphology for anodized tantalum, where the NT morphology was shown to be a potential candidate for orthopedic applications.

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Section: Results and Discussionmentioning

confidence: 99%

Morphology of Nanostructured Tantalum Oxide Controls Stem Cell Differentiation and Improves Corrosion Behavior

Erdogan,

Uslu,

Aydınol

et al. 2023

ACS Biomater. Sci. Eng.

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show abstract

“…[40] Additionally, the clustered TiO 2 nanotube surface modified by plateletderived growth factor (PDGF)-BB boosted the osteogenic differentiation of MSCs and bone regeneration in vivo. [41] Interestingly, besides osteogenic differentiation, arrays of TiO 2 nanotubes with a diameter of 30 nm showed the potential for vascularization by increasing the activity of endothelial cells, [42] and the ≈85 nm spaced Ti nanorod array switched macrophage (M𝜑) from M1 to M2 phenotype. [43] Notably, nanoporous Ti surface with about 30 nm diameter alleviated the inhibition of osteoclasts on osteogenesis by changing the secretion of cytokines and accelerated bone regeneration by macrophage cytokine profiles, which indicated that the morphology of Ti surface was critical for modulating monocyte/M𝜑 lineage commitment, thereby providing guidance for promoting osseointegration by coupling the osteogenesis and osteoclastogenesis (Figure 1c).…”

Section: Ti-based Nanostructuresmentioning

confidence: 99%

Materials‐Mediated In Situ Physical Cues for Bone Regeneration

Liu,

Zhang,

et al. 2023

Adv Funct Materials

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Physical cues like morphology, light, electric signal, mechanic signal, magnetic signal, and heat can be used as alternative regulators for expensive but short‐acting growth factors in bone tissue engineering to promote osteogenic differentiation and bone regeneration. As physical stimulation applied directly to the tissue cannot be focused on the bone defect area to regulate the cell behaviors and fate in situ, this limits the efficiency of precise bone regeneration. Biomaterials‐mediated in situ physical cues, as an effective strategy combining the synergistic effect of materials themselves, are put forward and studied widely to promote osteogenic differentiation and bone repair efficiently and precisely. Different types of physical cues provide different choices to better satisfy the requirements for targeted bone defect repair. In this review, the recent research about different biomaterials‐mediated physical cues accelerating osteogenesis in vitro and promoting in situ bone formation in vivo is introduced. Meanwhile, the corresponding possible mechanisms of various physical cues regulating cell responses are also discussed. This review provides useful and enlightening guidance for the utilization of intrinsically physical properties of functional materials to achieve efficient bone regeneration, leading to the design and construction of smart biomaterials for practical applications, and eventually promoting clinical translation.

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“…Differentiation of macrophages in vivo is the result of changes in the microenvironment, 45 which is highly related to the surface properties of biomaterials. In this study, we demonstrated that Tanfloc could inhibit the preinflammatory differentiation induced by LPS, a classic inflammation factor produced by bacteria that widely existed in sites with peri-implantitis.…”

Section: Cell Proliferation Testmentioning

confidence: 99%

Colloidal Phenol-Amine Coating on Implants for Improved Anti-Inflammation and Osteogenesis

Liang,

Chen,

Zhu

et al. 2023

ACS Biomater. Sci. Eng.

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Phenol-amine coatings have attracted significant attention in recent years owing to their adjustable composition and multifaceted biological functionalities. The current preparation of phenol-amine coatings, however, involves a chemical reaction within the solution or interface, resulting in lengthy preparation times and necessitating specific reaction conditions, such as alkaline environments and oxygen presence. The facile, rapid, and eco-friendly preparation of phenol-amine coatings under mild conditions continues to pose a challenge. In this study, we use a macromolecular phenol-amine, Tanfloc, to form a stable colloid under neutral conditions, which was then rapidly adsorbed on the titanium surface by electrostatic action and then spread and fused to form a continuous coating within several minutes. This nonchemical preparation process was rapid, mild, and free of chemical additives. The in vitro and in vivo results showed that the Tanfloc colloid fusion coating inhibited destructive inflammation, promoted osteogenesis, and enhanced osteointegration. These remarkable advantages of the colloidal phenol-amine fusion coating highlight the suitability of its future application in clinical practice.

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Nanostructured Titanium Implant Surface Facilitating Osseointegration from Protein Adsorption to Osteogenesis: The Example of TiO2 NTAs

Cited by 44 publications

References 120 publications

Morphology of Nanostructured Tantalum Oxide Controls Stem Cell Differentiation and Improves Corrosion Behavior

Morphology of Nanostructured Tantalum Oxide Controls Stem Cell Differentiation and Improves Corrosion Behavior

Materials‐Mediated In Situ Physical Cues for Bone Regeneration

Colloidal Phenol-Amine Coating on Implants for Improved Anti-Inflammation and Osteogenesis

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