Nanostructured Titanium Alloys Surface Modification Technology for Antibacterial and Osteogenic Properties

Wang, Qingge; Wu, Lihui; Liu, Shifeng; Cao, Peng; Yang, Junlin; Wang, Liqiang

doi:10.2174/1573413716666200217104004

Cited by 6 publications

(4 citation statements)

References 200 publications

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“…As shown in Figure 7 [56,57], the antibacterial modification of orthopedic implants can also be divided into bacterial repelling and killing, in addition to other specific properties. Researchers have designed various surfaces for orthopedic implants to inhibit the formation of biofilms [58][59][60], such as anti-adhesion surfaces, responsive biocides-containing coating.…”

Section: Orthopedic Implantsmentioning

confidence: 99%

Antibacterial surfaces: Strategies and applications

Yang

Hou

Tian

et al. 2022

Sci. China Technol. Sci.

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Antibacterial surfaces are surfaces that can resist bacteria, relying on the nature of the material itself. It is significant for safe food and water, human health, and industrial equipment. Biofilm is the main form of bacterial contamination on the material surface. Preventing the formation of biofilm is an efficient way to develop antibacterial surfaces. The strategy for constructing the antibacterial surface is divided into bacteria repelling and bacteria killing based on the formation of the biofilm. Material surface wettability, adhesion, and steric hindrance determine bacteria repelling performance. Bacteria should be killed by surface chemistry or physical structures when they are attached to a material surface irreversibly. Killing approaches are usually in the light of the cell membrane of bacteria. This review summarizes the fabrication methods and applications of antibacterial surfaces from the view of the treatment of the material surfaces. We also present several crucial points for developing long-term stability, no drug resistance, broad-spectrum, and even programable antibacterial surfaces.

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Section: Orthopedic Implantsmentioning

confidence: 99%

Antibacterial surfaces: Strategies and applications

Yang

Hou

Tian

et al. 2022

Sci. China Technol. Sci.

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“…Ion implantation is a well-established method in tuning material and surface characteristics [ 62 , 63 , 64 ]. Indeed, Kupferer et al have recently reported that low-energy low-fluence ion implantation of TNSs not only promotes smoothing and surface relaxation, it is further connected to a considerable change in chemical composition and electrical conductivity [ 49 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

Laminin Adsorption and Adhesion of Neurons and Glial Cells on Carbon Implanted Titania Nanotube Scaffolds for Neural Implant Applications

et al. 2022

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Interfacing neurons persistently to conductive matter constitutes one of the key challenges when designing brain-machine interfaces such as neuroelectrodes or retinal implants. Novel materials approaches that prevent occurrence of loss of long-term adhesion, rejection reactions, and glial scarring are highly desirable. Ion doped titania nanotube scaffolds are a promising material to fulfill all these requirements while revealing sufficient electrical conductivity, and are scrutinized in the present study regarding their neuron–material interface. Adsorption of laminin, an essential extracellular matrix protein of the brain, is comprehensively analyzed. The implantation-dependent decline in laminin adsorption is revealed by employing surface characteristics such as nanotube diameter, ζ-potential, and surface free energy. Moreover, the viability of U87-MG glial cells and SH-SY5Y neurons after one and four days are investigated, as well as the material’s cytotoxicity. The higher conductivity related to carbon implantation does not affect the viability of neurons, although it impedes glial cell proliferation. This gives rise to novel titania nanotube based implant materials with long-term stability, and could reduce undesirable glial scarring.

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“…The most common reasons for revisions include aseptic loosening, instability, infections, and osteolysis [ 8 ]. With appropriate implant design and modifications, it is possible to improve osseointegration and antibacterial activity, thus reducing the risk of infection [ 9 , 10 , 11 ]. For example, graphene oxide-modified titanium surfaces have been found to have antibacterial and osteogenic activity that increases with the number of graphene oxide layers [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Growth Factors in Bioactive Coatings

Bjelić

Finšgar

2021

Pharmaceutics

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With increasing obesity and an ageing population, health complications are also on the rise, such as the need to replace a joint with an artificial one. In both humans and animals, the integration of the implant is crucial, and bioactive coatings play an important role in bone tissue engineering. Since bone tissue engineering is about designing an implant that maximally mimics natural bone and is accepted by the tissue, the search for optimal materials and therapeutic agents and their concentrations is increasing. The incorporation of growth factors (GFs) in a bioactive coating represents a novel approach in bone tissue engineering, in which osteoinduction is enhanced in order to create the optimal conditions for the bone healing process, which crucially affects implant fixation. For the application of GFs in coatings and their implementation in clinical practice, factors such as the choice of one or more GFs, their concentration, the coating material, the method of incorporation, and the implant material must be considered to achieve the desired controlled release. Therefore, the avoidance of revision surgery also depends on the success of the design of the most appropriate bioactive coating. This overview considers the integration of the most common GFs that have been investigated in in vitro and in vivo studies, as well as in human clinical trials, with the aim of applying them in bioactive coatings. An overview of the main therapeutic agents that can stimulate cells to express the GFs necessary for bone tissue development is also provided. The main objective is to present the advantages and disadvantages of the GFs that have shown promise for inclusion in bioactive coatings according to the results of numerous studies.

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Nanostructured Titanium Alloys Surface Modification Technology for Antibacterial and Osteogenic Properties

Cited by 6 publications

References 200 publications

Antibacterial surfaces: Strategies and applications

Antibacterial surfaces: Strategies and applications

Laminin Adsorption and Adhesion of Neurons and Glial Cells on Carbon Implanted Titania Nanotube Scaffolds for Neural Implant Applications

The Role of Growth Factors in Bioactive Coatings

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