Nanostructured systems for transbuccal drug delivery

Franz-Montan, Michelle; Araújo, Daniele Ribeiro de; Ribeiro, Lígia Nunes de Morais; Melo, Nathalie Ferreira Silva de; Paula, Eneida de

doi:10.1016/b978-0-323-47720-8.00005-5

Cited by 18 publications

(12 citation statements)

References 130 publications

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“…Moreover, prolonged in vitro SMT release was observed for both NE/ALG-SMT and NE/PCT-SMT in comparison to free SMT. In addition, a burst release effect was observed for both NE in the first 2 h of analysis, which is desirable for pain management drugs (Franz-Montan et al, 2017a). The nonencapsulated fraction of SMT ensured the immediate onset of analgesia, followed by a sustained release of SMT loaded by copaiba oil nanoparticles.…”

Section: Discussionmentioning

confidence: 95%

Functional Hybrid Nanoemulsions for Sumatriptan Intranasal Delivery

et al. 2020

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Section: Discussionmentioning

confidence: 95%

Functional Hybrid Nanoemulsions for Sumatriptan Intranasal Delivery

et al. 2020

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“…In the hybridization approach, benefits from the nanostructured particles and polymers were combined into a single pharmaceutical form: the sustained release profile of NLC-encapsulated LA and the appropriate viscosity, consistency, and adhesion of the biopolymer matrix, to provide efficient topical anesthesia of the oral mucosa. 17 Despite the best mucoadhesion of CHT, 37 its incompatibility with NLC formulations led to separation, 38 probably due to the tripolyphosphate ionic crosslinking. Moreover, the use of weak acid in the polymer preparation and its undesirable flavor 39 viscosity.…”

Section: Discussionmentioning

confidence: 99%

“…16 In the DDS field, these advanced hybrid materials combine structural, physicochemical, mechanical, and therapeutic properties of each excipient in a single final form. Hybridization enables the development of smart formulations or pharmaceutical forms that are able to specifically interact with biological barriers, 17 such as the mucosal tissues and skin. There are some reports of lipid-biopolymer hydrogels for the topical sustained release of ibuprofen, 18 ketoprofen, 19 ofloxacin, 20 Resina draconis, 21 clobetasol, 22 and LAs, [23][24][25] which exhibited optimized properties in comparison to their lipid-related DDS.…”

Section: Introductionmentioning

confidence: 99%

Nanohybrid hydrogels designed for transbuccal anesthesia

Ribeiro

Franz-Montan

Breitkreitz

et al. 2018

IJN

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BackgroundLocal anesthesia in dentistry is by far the most terrifying procedure for patients, causing treatment interruption. None of the commercially available topical formulations is effective in eliminating the pain and phobia associated to the needle insertion and injection.Materials and methodsIn this work we prepared a nanostructured lipid-biopolymer hydrogel for the sustained delivery of lidocaine–prilocaine (LDC-PLC) for transbuccal pre-anesthesia. The lipid was composed of optimized nanostructured lipid carriers (NLC) loaded with 5% LDC-PLC (NLC/LDC-PLC). The biopolymer counterpart was selected among alginate, xanthan (XAN), and chitosan matrices. The XAN-NLC hydrogel presented the most uniform aspect and pseudoplastic rheological profile, as required for topical use; therefore, it was selected for subsequent analyses. Accelerated stability tests under critical conditions (40°C; 75% relative humidity) were conducted for 6 months, in terms of drug content (mg/g), weight loss (%), and pH.ResultsIn vitro LDC-PLC release profile through Franz diffusion cells revealed a bimodal kinetics with a burst effect followed by the sustained release of both anesthetics, for 24 hours. Structural analyses (fourier transform infrared spectroscopy, differential scanning calorimetry and scanning electron microscopy) gave details on the molecular organization of the hybrid hydrogel, confirming the synergic interaction between the components. Safety and efficacy were evaluated through in vitro cell viability (3T3, HaCat, and VERO cells) and in vivo antinociceptive (tail-flick, in mice) tests, respectively. In comparison to a control hydrogel and the eutectic mixture of 5% LDC-PLC cream (EMLA®), the XAN-NLC/LDC-PLC hybrid hydrogel doubled and quadrupled the anesthetic effect (8 hours), respectively.ConclusionConsidering such exciting results, this multifaceted nanohybrid system is now ready to be further tested in clinical trials.

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“…This arsenic-based device consisted of a new treatment against syphilis, the most efficient anti-syphilitic agent until the penicillin discovery in 1940 [ 62 , 63 ]. Since then, the multidisciplinary DDS field has grown exponentially, especially those designed from nanotechnology [ 64 ].…”

Section: Nanostructured Drug-delivery Systemsmentioning

confidence: 99%

The Role of Pharmaceutical Nanotechnology in the Time of COVID-19 Pandemic

Ribeiro

Fonseca

2020

Future Microbiol.

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There is no effective therapy against COVID-19 available so far. In the last months, different drugs have been tested as potential treatments for COVID-19, exhibiting high toxicity and low efficacy. Therefore, nanotechnology can be applied to improve the therapeutic action and minimize the toxicity of loaded drugs. In this review, we summarized the drugs tested as COVID-19 treatment and the advantages of antiviral nanostructured drug-delivery systems. Such systems have demonstrated low in vitro toxicity with better in vitro antiviral activity than free drugs. We believe that this approach should inspire novel nanostructured drug-delivery systems developments to find efficient COVID-19 treatments. Here, we discuss the remaining challenges for such promising nanosystems to be approved for clinical use.

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Nanostructured systems for transbuccal drug delivery

Cited by 18 publications

References 130 publications

Functional Hybrid Nanoemulsions for Sumatriptan Intranasal Delivery

Functional Hybrid Nanoemulsions for Sumatriptan Intranasal Delivery

Nanohybrid hydrogels designed for transbuccal anesthesia

The Role of Pharmaceutical Nanotechnology in the Time of COVID-19 Pandemic

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