Nanostructured self assembled monolayers on magnesium for improved biological performance

Mahapatro, Anil; Negrón, Taína D. Matos; Gomes, Anosh Steffin

doi:10.1080/10667857.2016.1222053

Cited by 31 publications

(7 citation statements)

References 87 publications

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“…The synergistic ROP of lactones using lipase and microwave radiation was applied to the solvent‐free polymerization of ϵ‐CL [69] and ω‐PDL, [70] yielding poly‐ϵ‐CL with M n of 20,624 g/mol and PDI of 1.2 (four hours reaction at 90 °C and 50 W, with Novozym®435 10 wt%) and poly‐ω‐PDL 24,997 g/mol M n and 1.93 PDI (four hours reaction at 70 °C and 200 W, with Novozym®435 10 wt%). Compared to using lipase and traditional heating, microwave‐assisted lipase‐catalyzed ROP of lactones increased the molecular weight of the synthesized aliphatic polyesters and decreased the PDI but was requiring controlled and limited microwave intensity.…”

Section: Erop Of Lactonesmentioning

confidence: 99%

Enzymatic Ring‐Opening Polymerization of Lactones: Traditional Approaches and Alternative Strategies

et al. 2019

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Biodegradable polymers such as polylactides and other polylactones and their synthesis gain progressively importance. Enzymatic ring‐opening polymerization (eROP) is the next step sustainable synthesis of polyesters, also suitable for biomedical applications due to high selectivity and lack of toxic agents. The possibility for applying diverse reaction media ranging from traditional bulk and organic media to greener alternatives such as aqueous media, ionic liquids, and supercritical fluids may allow designing alternative non‐conventional processes with less environmental footprint. Target success criteria such as high molecular weight and uniformity of polymers, and conversion of monomers have to be carefully evaluated in these diverse media. Herein we discuss the influence of different reaction media and conditions such as water content, temperature and time on the polymer sizes achieved in eROPs and various approaches to improve the molecular weight and uniformity of polymers.

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Section: Erop Of Lactonesmentioning

confidence: 99%

Enzymatic Ring‐Opening Polymerization of Lactones: Traditional Approaches and Alternative Strategies

et al. 2019

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“…Current research is now focused on developing improved Mg alloys with lower biodegradation rates by utilizing surface modification techniques. Mahapatro et al 9 have described an interesting method to develop a self-assembled monolayers (SAMs) on the surface of magnesium alloy. Similarly, Wang et al 10 developed Si-containing coatings through a chemical deposition method on the surface of AZ31B alloy to decrease the biodegradation rate of the alloy.…”

Section: Devesh Misramentioning

confidence: 99%

Special issue – recent advances in nanostructured implantable biomaterials

Misra¹

2016

Materials Technology

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“…Similarly, OTS modification has been shown to strengthen the interface compatibility between the HA surface and PLLA in developing macroporous composites with interconnected porous structure . Deposition of nanosized self-assembled monolayers of OTS on magnesium alloys showed enhanced biocompatibility with favorable corrosion behavior . Bacterial cellulose (BC) modified with OTS was shown to have an enhanced hydrophobic structure with lower cellular viability of dermal fibroblasts delineating to be a suitable candidate for anticancer/antibacterial applications …”

Section: Introductionmentioning

confidence: 99%

“…24 Deposition of nanosized self-assembled monolayers of OTS on magnesium alloys showed enhanced biocompatibility with favorable corrosion behavior. 25 Bacterial cellulose (BC) modified with OTS was shown to have an enhanced hydrophobic structure with lower cellular viability of dermal fibroblasts delineating to be a suitable candidate for anticancer/antibacterial applications. 19 Herein, BF endosperm was chosen as a suitable material for developing 3D cellulosic scaffolds owing to its unique morphological and vasculature structure, which is highly fibrous and interconnected, that mimics the porous microarchitecture of native animal ECM.…”

Section: Introductionmentioning

confidence: 99%

Surface Modification of Decellularized Natural Cellulose Scaffolds with Organosilanes for Bone Tissue Regeneration

Mahendiran

Muthusamy

Janani

et al. 2022

ACS Biomater. Sci. Eng.

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The utility of plant tissues as scaffolding materials has been gaining significant interest in recent years owing to their unique material characteristics that are ideal for tissue regeneration. In this study, the degradation and biocompatibility of natural cellulosic scaffolds derived from Borassus f labellifer (Linn.) (BF) immature endosperm was improved by chemical oxidation and surface functionalization processes. Briefly, thus obtained cellulosic scaffolds were sequentially processed via a detergent exchange decellularization process followed by sodium periodate mediated oxidation and organosilane-based surface modification using amino (NH 2 )terminated 3-aminopropyltriethoxysilane (APTES) and methyl (CH 3 )terminated octadecyltrichlorosilane (OTS). Post oxidation and surface functionalization, the scaffolds showed improved physiochemical, morphological, and mechanical properties. Especially, the swelling capacity, total porosity, surface area, degradation kinetics, and mechanical behavior of scaffold were significantly higher in modified scaffold groups. The biocompatibility analysis demonstrated excellent cellular adhesion, proliferation and differentiation of osteoblasts with an evident upregulation of mineralization. Subcutaneous implantation of these scaffolds in a rat model demonstrated active angiogenesis, enhanced degradation, and excellent biocompatibility with concomitant deposition of a collagen matrix. Taken together, the native cellulosic scaffolds post chemical oxidation and surface functionalization can exclusively integrate the potential properties of native soft tissue with ameliorated in vitro and in vivo support in bone tissue engineering for nonloading bearing applications.

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Nanostructured self assembled monolayers on magnesium for improved biological performance

Cited by 31 publications

References 87 publications

Enzymatic Ring‐Opening Polymerization of Lactones: Traditional Approaches and Alternative Strategies

Enzymatic Ring‐Opening Polymerization of Lactones: Traditional Approaches and Alternative Strategies

Special issue – recent advances in nanostructured implantable biomaterials

Surface Modification of Decellularized Natural Cellulose Scaffolds with Organosilanes for Bone Tissue Regeneration

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