Nanostructured products of the drug theophylline caused by charge transfer interactions and a binary solvent system: Morphology and nanometry

Charge transfer interaction of organic p-acceptors with the anti-hyperuricemic drug allopurinol: Insights from IR, Raman, 1H NMR and 13C NMR spectroscopies

“…H NMR spectrum of free Allop, the proton of the pyrimidine ring N-H was observed as a singlet signal at 3.84 ppm, and that of pyrazole ring N-H appeared as a singlet at 12.87 ppm (18). The signal due to the phenolic proton (-OH) of the PA acceptor, which is observed at d ~11.94 ppm (10) in the spectrum of the free PA acceptor, is no longer observed. Instead, a new signal is located at approximately ~6.83 ppm.…”

“…Studies of the charge-transfer (CT) or proton-transfer (PT) interactions of drugs have attracted considerable interest and have become a popular area of research because of their unique physical and chemical properties and wide range of applications (10). The chemistry of these interactions has received considerable attention in pharmacology, chemistry, biology and medicine.…”

“…The chemistry of these interactions has received considerable attention in pharmacology, chemistry, biology and medicine. They play crucial roles in many processes; therefore, understanding these interactions is important for the understanding of drug-receptor binding and the drug's mechanism of action as well as for obtaining quantitative estimates of drugs (10)(11)(12).…”

Charge-transfer Complexes Formed between the Sweeteners Saccharin Drug and Acido Acceptors: Structural, Thermal and Morphological Features

“…They found that a hydrogen bonding is existed between the two protons (-OH) of S(=O) 2 -OH group of the dye and the acidic central position (-OH) of the CLA and PA acceptors. The morphology and nanometry of nanostructured products formed from the interaction between drug theophylline and some organic acceptors were investigated by Adam and Refat (2015). They indicated that the complexation of theophylline with PA acceptor leads to the formation of a hydrogen bonding with a proton transfer.…”

Charge-transfer chemistry of azithromycin, the antibiotic used worldwide to treat the coronavirus disease (COVID-19). Part II: Complexation with several π-acceptors (PA, CLA, CHL)

“…The CLA molecule has two chloro groups and two carbonyl groups, whereas the CHL molecule has four chloro groups and two carbonyl groups. These groups act as electron-withdrawing systems that decrease the electron density of the aromatic rings of CLA and CHL, thereby rendering them robust electron-accepting systems [ 35 , 149 , [164] , [165] , [166] , [167] , [168] ]. The purpose of this work was to investigate the CT interaction of AZM with three π-acceptors (PA, CLA, and CHL) in MeOH solvent.…”