Nanostructured lipid carriers containing chitosan or sodium alginate for co-encapsulation of antioxidants and an antimicrobial agent for potential application in wound healing

Costa-Fernandez, Sandra; Matos, Jenyffer K.R. de; Scheunemann, Gaby; Salata, Giovanna Cassone; Chorilli, Marlus; Watanabe, Il-Sei; Araujo, Gabriel Lima Barros de; Santos, Marinilce Fagundes dos; Ishida, Kelly; Lopes, Luciana B.

doi:10.1016/j.ijbiomac.2021.04.168

Cited by 37 publications

(12 citation statements)

References 71 publications

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“…The antimicrobial activity of this formulation was further tested against P. aeruginosa, S. aureus, MRSA, and C. albicans. The hybrid carriers did not impede the activity of tea tree oil, and neither was it improved by the inclusion of the polymer [173].…”

Section: Coating Materials and Excipientsmentioning

confidence: 96%

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

2021

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Chitosan is one of the most studied natural origin polymers for biomedical applications. This review focuses on the potential of chitosan in localized antimicrobial therapy to address the challenges of current rising antimicrobial resistance. Due to its mucoadhesiveness, chitosan offers the opportunity to prolong the formulation residence time at mucosal sites; its wound healing properties open possibilities to utilize chitosan as wound dressings with multitargeted activities and more. We provide an unbiased overview of the state-of-the-art chitosan-based delivery systems categorized by the administration site, addressing the site-related challenges and evaluating the representative formulations. Specifically, we offer an in-depth analysis of the current challenges of the chitosan-based novel delivery systems for skin and vaginal infections, including its formulations optimizations and limitations. A brief overview of chitosan’s potential in treating ocular, buccal and dental, and nasal infections is included. We close the review with remarks on toxicity issues and remaining challenges and perspectives.

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Section: Coating Materials and Excipientsmentioning

confidence: 96%

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

2021

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“…Therefore, there is a constant search for novel antioxidant molecules that can help to regulate this system. Among all the studied molecules, chitosan appears to be one of the most promising agents for the regulation of ROS levels [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Preparation, Structural Characterization, and Property Investigation of Gallic Acid-Grafted Fungal Chitosan Conjugate

Paiva

Queiroz

Sabry

et al. 2021

JoF

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Oxidative stress is the cause of numerous diseases in humans; therefore, there has been a continuous search for novel antioxidant molecules. Fungal chitosan is an attractive molecule that has several applications (antifungal, antibacterial, anticancer and antiparasitic action) owing to its unique characteristics; however, it exhibits low antioxidant activity. The aim of this study was to obtain fungal chitosan (Chit-F) from the fungus Rhizopus arrhizus and synthesize its derivative, fungal chitosan-gallic acid (Chit-FGal), as a novel antioxidant chitosan derivative for biomedical use. A low molecular weight Chi-F (~3.0 kDa) with a degree of deacetylation of 86% was obtained from this fungus. Chit-FGal (3.0 kDa) was synthesized by an efficient free radical-mediated method using hydrogen peroxide (H2O2) and ascorbic acid. Both Chit-F and Chit-FGal showed similar copper chelating activities; however, Chit-FGal was more efficient as an antioxidant, exhibiting twice the total antioxidant capacity than Chi-F (p < 0.05). Furthermore, H2O2 (0.06 M) promoted a 50% decrease in the viabilities of the 3T3 fibroblast cells. However, this effect was abolished in the presence of Chit-FGal (0.05–0.25 mg/mL), indicating that Chit-FGal protected the cells from oxidative damage. These results suggest that Chit-FGal may be a promising agent to combat oxidative stress.

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“…Stability of the nanoemulsions with different medium-chain coconut or palm oil as lipid phase was evaluated (Figure C). Costa-Fernandez et al developed a bioadhesive nanostructured lipid carriers to accelerate wound healing . The actives in tea tree oil provided long-term antibacterial ability and prevent its evaporation was an interesting highlight of this study (Figure D).…”

Section: Applications Of Beneficial Functional Lipid Capsulesmentioning

confidence: 85%

“…Copyright 2021. Reproduced with permission from Elsevier Science Ltd. (D) Scanning electron microscopy of nanostructured lipid carriers: (A and C) modified with sodium chitosan amd (B and D) modified with alginate (scale bar, 5 μm for parts A and C; 1 μm for parts B and D) . Copyright 2021.…”

Section: Applications Of Beneficial Functional Lipid Capsulesmentioning

confidence: 99%

Encapsulated Microstructures of Beneficial Functional Lipids and Their Applications in Foods and Biomedicines

Cai

Zhang

et al. 2022

J. Agric. Food Chem.

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Beneficial functional lipids are essential nutrients for the growth and development of humans and animals, which nevertheless possess poor chemical stability because of heat/light-sensitivity. Various encapsulation technologies have been developed to protect these nutrients against adverse factors. Different microstructures are exhibited through different encapsulation methods, which influence the encapsulation efficiency and release behavior at the same time. This review summarizes the effects of preparation methods and process parameters on the microstructures of capsules at first. The mechanisms of the different microstructures on encapsulation efficiency and controlled release behavior of core materials are analyzed. Next, a comprehensive overview on the beneficial functional lipids capsules in the latest food and biomedicine applications are provided as well as the matching relationship between the microstructures of the capsules and applications are discussed. Finally, the remaining challenges and future possible directions that have potential interest are outlined. The purpose of this review is to convey the construction of beneficial functional lipids capsules and the function mechanism, a critical analysis on its current status and challenges, and opinions on its future development. This review is believed to promote communication among the food, pharmacy, agronomy, engineering, and nutrition industries.

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Nanostructured lipid carriers containing chitosan or sodium alginate for co-encapsulation of antioxidants and an antimicrobial agent for potential application in wound healing

Cited by 37 publications

References 71 publications

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

Preparation, Structural Characterization, and Property Investigation of Gallic Acid-Grafted Fungal Chitosan Conjugate

Encapsulated Microstructures of Beneficial Functional Lipids and Their Applications in Foods and Biomedicines

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