Nanostructured biomaterials for in vitro models of bone metastasis cancer

Katti, Kalpana S.; Jasuja, Haneesh; Kar, Sumanta; Katti, Dinesh R.

doi:10.1016/j.cobme.2020.100254

Cited by 10 publications

(9 citation statements)

References 70 publications

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“…Due to its osteoinductivity and osteoconductivity properties, HA in scaffolds can accelerate new bone tissue formation [11]. As a significant factor in advancing the medical engineering field, nanotechnology can create superior capabilities in biomaterials by modifying their structures [12,13]. For example, upon modifying the crystal structure of HA by doping with antibacterial elements, and further compositing it with carbon nanomaterials, can not only improve the new HA nanocomposite material's bioactivity but also its other biological features such as antibacterial properties [14,15].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Cellular Behaviors of Novel Zinc-Doped Hydroxyapatite/Graphene Nanocomposite for Bone Tissue Engineering

Maleki-Ghaleh

Siadati

Fallah

et al. 2021

IJMS

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Bacteria are one of the significant causes of infection in the body after scaffold implantation. Effective use of nanotechnology to overcome this problem is an exciting and practical solution. Nanoparticles can cause bacterial degradation by the electrostatic interaction with receptors and cell walls. Simultaneously, the incorporation of antibacterial materials such as zinc and graphene in nanoparticles can further enhance bacterial degradation. In the present study, zinc-doped hydroxyapatite/graphene was synthesized and characterized as a nanocomposite material possessing both antibacterial and bioactive properties for bone tissue engineering. After synthesizing the zinc-doped hydroxyapatite nanoparticles using a mechanochemical process, they were composited with reduced graphene oxide. The nanoparticles and nanocomposite samples were extensively investigated by transmission electron microscopy, X-ray diffraction, and Raman spectroscopy. Their antibacterial behaviors against Escherichia coli and Staphylococcus aureus were studied. The antibacterial properties of hydroxyapatite nanoparticles were found to be improved more than 2.7 and 3.4 times after zinc doping and further compositing with graphene, respectively. In vitro cell assessment was investigated by a cell viability test and alkaline phosphatase activity using mesenchymal stem cells, and the results showed that hydroxyapatite nanoparticles in the culture medium, in addition to non-toxicity, led to enhanced proliferation of bone marrow stem cells. Furthermore, zinc doping in combination with graphene significantly increased alkaline phosphatase activity and proliferation of mesenchymal stem cells. The antibacterial activity along with cell biocompatibility/bioactivity of zinc-doped hydroxyapatite/graphene nanocomposite are the highly desirable and suitable biological properties for bone tissue engineering successfully achieved in this work.

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Section: Introductionmentioning

confidence: 99%

Antibacterial and Cellular Behaviors of Novel Zinc-Doped Hydroxyapatite/Graphene Nanocomposite for Bone Tissue Engineering

Maleki-Ghaleh

Siadati

Fallah

et al. 2021

IJMS

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“…Finally, validation of novel therapeutic approaches requires testing in pre-clinical models of bone metastasis, which are not yet uniformly available for all bone metastatic cancer entities. While genetically engineered animal models for bone metastatic cancer are scarce, novel patient-derived xenograft models, as well as in vitro organoid and scaffold models recapitulating the bone niche, may be increasingly used to accelerate the development of bone metastasis-targeting compounds [ 259 , 306 , 307 , 308 , 309 , 310 , 311 ]. This most likely requires a joint and multidisciplinary effort between industry and academia to be eventually successful.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms, Diagnosis and Treatment of Bone Metastases

Ban

Fock

Aryee

et al. 2021

Cells

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Bone and bone marrow are among the most frequent metastatic sites of cancer. The occurrence of bone metastasis is frequently associated with a dismal disease outcome. The prevention and therapy of bone metastases is a priority in the treatment of cancer patients. However, current therapeutic options for patients with bone metastatic disease are limited in efficacy and associated with increased morbidity. Therefore, most current therapies are mainly palliative in nature. A better understanding of the underlying molecular pathways of the bone metastatic process is warranted to develop novel, well-tolerated and more successful treatments for a significant improvement of patients’ quality of life and disease outcome. In this review, we provide comparative mechanistic insights into the bone metastatic process of various solid tumors, including pediatric cancers. We also highlight current and innovative approaches to biologically targeted therapy and immunotherapy. In particular, we discuss the role of the bone marrow microenvironment in the attraction, homing, dormancy and outgrowth of metastatic tumor cells and the ensuing therapeutic implications. Multiple signaling pathways have been described to contribute to metastatic spread to the bone of specific cancer entities, with most knowledge derived from the study of breast and prostate cancer. However, it is likely that similar mechanisms are involved in different types of cancer, including multiple myeloma, primary bone sarcomas and neuroblastoma. The metastatic rate-limiting interaction of tumor cells with the various cellular and noncellular components of the bone-marrow niche provides attractive therapeutic targets, which are already partially exploited by novel promising immunotherapies.

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“…These materials can provide biophysical and biochemical signals to cells to promote tissue formation, whilst also enabling nutrient supply and waste removal to occur due the porous nature of the structures. Therefore, these materials enable better recreation of the metastatic microenvironment in which a secondary tumour forms in vivo ( 101 , 102 ). These novel biomaterials can be utilised in models which allow the study of tumour cells which metastasise to the bone.…”

Section: Bone Metastases Formation In Prostate Cancermentioning

confidence: 99%

Prostate cancer bone metastases biology and clinical management (Review)

2023

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Prostate cancer (PCa) is one of the most prominent causes of cancer-related mortality in the male population. A highly impactful prognostic factor for patients diagnosed with PCa is the presence or absence of bone metastases. The formation of secondary tumours at the bone is the most commonly observed site for the establishment of PCa metastases and is associated with reduced survival of patients in addition to a cohort of life-debilitating symptoms, including mobility issues and chronic pain. Despite the prevalence of this disease presentation and the high medical relevance of bone metastases, the mechanisms underlying the formation of metastases to the bone and the understanding of what drives the osteotropism exhibited by prostate tumours remain to be fully elucidated. This lack of in-depth understanding manifests in limited effective treatment options for patients with advanced metastatic PCa and culminates in the low rate of survival observed for this sub-set of patients. The present review aims to summarise the most recent promising advances in the understanding of how and why prostate tumours metastasise to the bone, with the ultimate aim of highlighting novel treatment and prognostic targets, which may provide the opportunity to improve the diagnosis and treatment of patients with PCa with bone metastases.

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Nanostructured biomaterials for in vitro models of bone metastasis cancer

Cited by 10 publications

References 70 publications

Antibacterial and Cellular Behaviors of Novel Zinc-Doped Hydroxyapatite/Graphene Nanocomposite for Bone Tissue Engineering

Antibacterial and Cellular Behaviors of Novel Zinc-Doped Hydroxyapatite/Graphene Nanocomposite for Bone Tissue Engineering

Mechanisms, Diagnosis and Treatment of Bone Metastases

Prostate cancer bone metastases biology and clinical management (Review)

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