Nanostructure formation in aqueous solution of amphiphilic copolymers of 2-(N,N-dimethylaminoethyl)methacrylate and alkylacrylate: Characterization, antimicrobial activity, DNA binding, and cytotoxicity studies

Dutta, Pranabesh; Dey, Joykrishna; Shome, Anshupriya; Das, Prasanta Kumar

doi:10.1016/j.ijpharm.2011.05.006

Cited by 21 publications

(19 citation statements)

References 49 publications

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“…47 Moreover the cytotoxicity can be reduced by increasing the hydrophobicity of the polymer. 26, 49 The superior compounds were also tested for their cytotoxicity to mammalian cells (HepG2), and the quaternized polymers proved less toxic than the non-quaternized polymers as shown in Figure 5.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial low molecular weight cationic polymers: dissecting the contribution of hydrophobicity, chain length and charge to activity

Grace

Huang

Cheah³

et al. 2016

RSC Adv.

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The balance of cationicity and hydrophobicity can profoundly affect the performance of antimicrobial polymers. To this end a library of 24 cationic polymers with uniquely low degrees of polymerization was synthesized via Cu(0)-mediated polymerization, using three different cationic monomers and two initiators: providing two different hydrocarbon chain tail lengths (C2 and C12). The polymers exhibited structure-dependent antibacterial activity when tested against a selection of bacteria, viz, Staphylococcus aureus ATCC 29213, Klebsiella pneumoniae ATCC 13883, Acinetobacter baumannii ATCC 19606, and Pseudomonas aeruginosa ATCC 27853 as a representative palette of Gram-positive and Gram-negative ESKAPE pathogens. The five best-performing polymers were identified for additional testing against the polymyxin-resistant A. baumannii ATCC 19606R strain. Polymers having the lowest DP and a C12 hydrophobic tail were shown to provide the broadest antimicrobial activity against the bacteria panel studied as evidenced by lower minimum inhibitory concentrations (MICs). An optimal polymer composition was identified, and its mechanism of action investigated via membrane permeability testing against Escherichia coli. Membrane disruption was identified as the most probable mechanism for bacteria cell killing.

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Section: Resultsmentioning

confidence: 99%

Antibacterial low molecular weight cationic polymers: dissecting the contribution of hydrophobicity, chain length and charge to activity

Grace

Huang

Cheah³

et al. 2016

RSC Adv.

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“…These materials are likely to bind to enzymes or microbial proteins, and without migration, effectively inhibit surface growth of microorganisms [18,56]. According to Dutta et al [57], the hydrophilic-hydrophobic balance of a substance, as well as the nature of long chains (hydrophobic), is more consistent with the cytoplasmic lipid membrane, which is largely responsible for its antimicrobial properties. Therefore, the release of the antimicrobial agent through the cell wall requires optimum hydrophobicity.…”

Section: Active Film Preparationmentioning

confidence: 99%

Properties and Application of Multifunctional Composite Polypropylene-Based Films Incorporating a Combination of BHT, BHA and Sorbic Acid in Extending Donut Shelf-Life

et al. 2020

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To extend the shelf-life of packaged donut without the addition of preservative, polypropylene-based active composite films loaded with a combination of sorbic acid, BHA and BHT were prepared by the extrusion moulding method: T1 (Control-pure PP-film), T2 (PP-BHT1%-SA2%), T3 (PP-BHA3%-SA2%) and T4 (PP-BHT1%-BHA1%-SA2%). The incorporation of active additives enhanced water vapour permeability (WVP) and increased oxygen permeability of films. Active films had higher antioxidant activity than pure PP in the order T4 > T2 > T3 (89.11, 83.40 and 79.16%). In vitro examinations demonstrated a significant antibacterial effect on Escherichia coli and S. aureus growth. Overall migration was not significantly different for watery food simulants, while in acidic and fatty foods increased it significantly. The effect of the active films on the fried and packaged donut samples showed significantly higher moisture contents and peroxide values, while acidity was lower. T2 film is proposed due to the preservation of the intrinsic properties of the film, increasing the storage period up to 25 to 50 days.

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“…1 TPPC6MA was prepared by acylation of TPPC6-OH with methacryloyl chloride. 39 Typically, TPPC6-OH (0.365 g, 0.5 mmol), triethylamine (0.06 g, 0.6 mmol), and anhydrous THF (20 mL) were charged into a 50 mL flask. The mixture solution was cooled to 0 °C in an ice-water bath, and then methacryloyl chloride (0.062 g, 0.6 mmol) in 5 mL anhydrous THF was added dropwise into the solution under magnetic stirring.…”

Section: Synthesis Of 5-(4-hydroxylphenyl)-101520-triphenylporphyrin ...mentioning

confidence: 99%

Porphyrin-containing amphiphilic block copolymers for photodynamic therapy

Liu

et al. 2015

Polym. Chem.

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Nanostructure formation in aqueous solution of amphiphilic copolymers of 2-(N,N-dimethylaminoethyl)methacrylate and alkylacrylate: Characterization, antimicrobial activity, DNA binding, and cytotoxicity studies

Cited by 21 publications

References 49 publications

Antibacterial low molecular weight cationic polymers: dissecting the contribution of hydrophobicity, chain length and charge to activity

Antibacterial low molecular weight cationic polymers: dissecting the contribution of hydrophobicity, chain length and charge to activity

Properties and Application of Multifunctional Composite Polypropylene-Based Films Incorporating a Combination of BHT, BHA and Sorbic Acid in Extending Donut Shelf-Life

Porphyrin-containing amphiphilic block copolymers for photodynamic therapy

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