Nanostrip flexible microwave enzymatic biosensor for noninvasive epidermal glucose sensing

Xue, Qiannan; Li, Zheyu; Wang, Qikun; Pan, Wenwei; Chang, Ye; Duan, Xuexin

doi:10.1039/d0nh00098a

Cited by 36 publications

(17 citation statements)

References 65 publications

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“…It is illustrated in Figure 7 c. Integration with a nano strip antenna was proposed in this study to enhance the microwave signals, in turn improving the sensitivity of the sensor. A linear response for glucose concentration was recorded in the range 0.1 nM to 10 mM with sensitivity of 0.026 dB/log (nM) [ 111 ]. Dautta et al developed a wireless stretchable and scalable phenylboronic acid-based biosensor for glucose detection in sweat with a hydrogel-interlayer radiofrequency (RF) resonator.…”

Section: Recent Developments In Various Biological Fluid-based Glucos...mentioning

confidence: 99%

Recent Advancement in Biofluid-Based Glucose Sensors Using Invasive, Minimally Invasive, and Non-Invasive Technologies: A Review

Reddy

Agarwal

et al. 2022

Nanomaterials

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Biosensors have potentially revolutionized the biomedical field. Their portability, cost-effectiveness, and ease of operation have made the market for these biosensors to grow rapidly. Diabetes mellitus is the condition of having high glucose content in the body, and it has become one of the very common conditions that is leading to deaths worldwide. Although it still has no cure or prevention, if monitored and treated with appropriate medication, the complications can be hindered and mitigated. Glucose content in the body can be detected using various biological fluids, namely blood, sweat, urine, interstitial fluids, tears, breath, and saliva. In the past decade, there has been an influx of potential biosensor technologies for continuous glucose level estimation. This literature review provides a comprehensive update on the recent advances in the field of biofluid-based sensors for glucose level detection in terms of methods, methodology and materials used.

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Section: Recent Developments In Various Biological Fluid-based Glucos...mentioning

confidence: 99%

Recent Advancement in Biofluid-Based Glucose Sensors Using Invasive, Minimally Invasive, and Non-Invasive Technologies: A Review

Reddy

Agarwal

et al. 2022

Nanomaterials

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show abstract

“…[ 140,160,184 ] Owing to advancement of materials, fabrication techniques, and sampling approaches, a number of skin‐interfaced biosensors have been validated for their real‐time CGM in sweat during physiological activities ( Figure ). [ 135–161,185 ] Electrochemical sensors are the most commonly used method for wearable device design owing to their high sensitivity and simplicity, low‐cost fabrication, high speed, and high analytical performance. [ 186–188 ] Several strategies have been developed to optimize the on‐body sensing capability of these wearable electrochemical sensors.…”

Section: Emergence Of On‐body Wearable Glucose Continuous Monitoringmentioning

confidence: 99%

Trending Technology of Glucose Monitoring during COVID‐19 Pandemic: Challenges in Personalized Healthcare

Phan

Hoang

et al. 2021

Adv Materials Technologies

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The COVID‐19 pandemic has continued to spread rapidly, and patients with diabetes are at risk of experiencing rapid progression and poor prognosis for appropriate treatment. Continuous glucose monitoring (CGM), which includes accurately tracking fluctuations in glucose levels without raising the risk of coronavirus exposure, becomes an important strategy for the self‐management of diabetes during this pandemic, efficiently contributing to the diabetes care and the fight against COVID‐19. Despite being less accurate than direct blood glucose monitoring, wearable noninvasive systems can encourage patient adherence by guaranteeing reliable results through high correlation between blood glucose levels and glucose concentrations in various other biofluids. This review highlights the trending technologies of glucose sensors during the ongoing COVID‐19 pandemic (2019–2020) that have been developed to make a significant contribution to effective management of diabetes and prevention of coronavirus spread, from off‐body systems to wearable on‐body CGM devices, including nanostructure and sensor performance in various biofluids. The advantages and disadvantages of various human biofluids for use in glucose sensors are also discussed. Furthermore, the challenges faced by wearable CGM sensors with respect to personalized healthcare during and after the pandemic are deliberated to emphasize the potential future directions of CGM devices for diabetes management.

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“…Glucose sensing is an area in which a lot of different sensors have been developed [ 18 , 19 , 20 , 21 ]. Microwave sensors developed on flexible substrate materials are also researched with the added benefit of having a sensor that is conformal to the body and not a rigid structure [ 22 , 23 , 24 ]. Also, the feasibility of using the fat channel for intra-body communication at microwave frequencies has been studied [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

MAS: Standalone Microwave Resonator to Assess Muscle Quality

Mattsson

Ackermans

Mandal

et al. 2021

Sensors

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Microwave-based sensing for tissue analysis is recently gaining interest due to advantages such as non-ionizing radiation and non-invasiveness. We have developed a set of transmission sensors for microwave-based real-time sensing to quantify muscle mass and quality. In connection, we verified the sensors by 3D simulations, tested them in a laboratory on a homogeneous three-layer tissue model, and collected pilot clinical data in 20 patients and 25 healthy volunteers. This report focuses on initial sensor designs for the Muscle Analyzer System (MAS), their simulation, laboratory trials and clinical trials followed by developing three new sensors and their performance comparison. In the clinical studies, correlation studies were done to compare MAS performance with other clinical standards, specifically the skeletal muscle index, for muscle mass quantification. The results showed limited signal penetration depth for the Split Ring Resonator (SRR) sensor. New sensors were designed incorporating Substrate Integrated Waveguides (SIW) and a bandstop filter to overcome this problem. The sensors were validated through 3D simulations in which they showed increased penetration depth through tissue when compared to the SRR. The second-generation sensors offer higher penetration depth which will improve clinical data collection and validation. The bandstop filter is fabricated and studied in a group of volunteers, showing more reliable data that warrants further continuation of this development.

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Nanostrip flexible microwave enzymatic biosensor for noninvasive epidermal glucose sensing

Abstract: A nanostrip flexible microwave biosensor based on highly ordered nano-1D metamaterials is presented for epidermal trace glucose sensing.

Cited by 36 publications

References 65 publications

Recent Advancement in Biofluid-Based Glucose Sensors Using Invasive, Minimally Invasive, and Non-Invasive Technologies: A Review

Recent Advancement in Biofluid-Based Glucose Sensors Using Invasive, Minimally Invasive, and Non-Invasive Technologies: A Review

Trending Technology of Glucose Monitoring during COVID‐19 Pandemic: Challenges in Personalized Healthcare

MAS: Standalone Microwave Resonator to Assess Muscle Quality

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