Nanospheres as a technological alternative to suppress hepatic cellular damage and impaired bioenergetics caused by nerolidol in Nile tilapia (Oreochromis niloticus)

Curcumin, Curcumin Nanoparticles and Curcumin Nanospheres: A Review on Their Pharmacodynamics Based on Monogastric Farm Animal, Poultry and Fish Nutrition

“…The result of the experiment revealed that a single oral dose of 5 mg PLGA-curcumin containing 350µg of curcumin resulted in 3-to 4-fold higher concentration and prolonged presence of curcumin in the brain than that obtained with 5mg of native curcumin, indicating better bioavailability and more effective nature of PLGA-curcumin. Recently, Baldissera and his group [71,138,139] reported the potential effect of dietary nerolidol nanospheres at 0.5 or 1.0 mL/kg diet in Nile tilapia. The results demonstrated that nerolidol nanospheres supplementation improved the growth, survival, antioxidant activities and fillet fatty acids profile and attenuated/reduced hepatic cellular damage, impaired bioenergetics, microbial contents and neuronal damage as well as disease resistance against the pathogenic Gram-negative bacterium, Streptococcus agalactiae in Nile tilapia.…”