Nanosized Drug Carriers for Oral Delivery of Anticancer Compounds and the Importance of the Chromatographic Techniques

Sengel-Türk, Ceyda Tuba; Gümüştaş, Mehmet; Uslu, Bengi; Özkan, Síbel A.

doi:10.1016/b978-0-323-52727-9.00010-8

Cited by 13 publications

(11 citation statements)

References 141 publications

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“…Polymeric nanoparticles used as nanocarriers involve matrix architectures, most commonly in the form of nanocapsules and nanospheres [28,29]. The most widely used polymers for manufacturing these nanocarriers are biocompatible and biodegradable and of synthetic origin, such as polylactic acid, polyglycolic acid, polylactide-co-polyglycolic acid, poly(ε-caprolactone), and polymethyl methacrylate, and of natural origin, such as chitosan, alginate, gelatin, and albumin [28,30]. The pharmacokinetics of the encapsulated agents is mainly influenced by the structure of the polymer and the entrapping method [31].…”

Section: Nanocarriers For Brain Targetingmentioning

confidence: 99%

Neuronanomedicine: An Up-to-Date Overview

et al. 2019

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The field of neuronanomedicine has recently emerged as the bridge between neurological sciences and nanotechnology. The possibilities of this novel perspective are promising for the diagnosis and treatment strategies of severe central nervous system disorders. Therefore, the development of nano-vehicles capable of permeating the blood–brain barrier (BBB) and reaching the brain parenchyma may lead to breakthrough therapies that could improve life expectancy and quality of the patients diagnosed with brain disorders. The aim of this review is to summarize the recently developed organic, inorganic, and biological nanocarriers that could be used for the delivery of imaging and therapeutic agents to the brain, as well as the latest studies on the use of nanomaterials in brain cancer, neurodegenerative diseases, and stroke. Additionally, the main challenges and limitations associated with the use of these nanocarriers are briefly presented.

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Section: Nanocarriers For Brain Targetingmentioning

confidence: 99%

Neuronanomedicine: An Up-to-Date Overview

et al. 2019

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“…Since the compounds are polar, HILIC is an alternative for the separation and determination of this ternary mixture. It is very well known that the column chemistry, mobile phase composition, mobile phase ratio, buffer type and concentration, pH, flow rate, and temperature of the column can affect the retention mechanism as well as the selectivity [14,15]. For this reason, each step for the development of this methodology was demonstrated in detail.…”

Section: Results and Discussion 21 Step-by-step Development Of The mentioning

confidence: 99%

“…The superiority of these columns comes from superficially porous particles. The benefits of these materials have been mentioned in several publications [14][15][16][17]. When comparing the particle sizes, the estimation of smaller particles increased the efficiency.…”

Section: Optimization Of Stationary Phasementioning

confidence: 99%

Step-by-step optimization of the HILIC method for simultaneous determinationof abacavir, lamivudine, and zidovudine from dosage form

Erkmen¹,

Gümüştaş²,

Özkan³

et al. 2019

Turk J Chem

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Combined therapy for HIV treatment shows superior efficacy in comparison to single therapy. Furthermore, the separation and determination of the combined dosage forms hold a significant place in the pharmaceutical industry. Not only reverse phase high-performance liquid chromatography (HPLC) but also hydrophilic interaction liquid chromatography (HILIC) can be used for these purposes. Contrary to conventional RP systems, HILIC may be an alternative for the analysis of polar substances. The aim of this study was the step-by-step development of a simple, rapid, and reliable method for the simultaneous determination of antiviral compounds from their marketed formulation (Trizivir). In order to achieve this goal, various mobile phase systems, buffer types, and concentrations were prepared to provide an appropriate separation. Different types of columns were tested to find the best resolution and high efficiency for the studied compounds. The proposed method provided a simple procedure for the simultaneous analysis of abacavir, lamivudine, and zidovudine in their pharmaceutical preparation within approximately 2 min using the conventional HPLC system. The developed method was fully validated according to the International Council for Harmonisation guidelines from the viewpoint of selectivity, sensitivity, precision, accuracy, linearity, limit of detection, and quantification.

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“…In nanotechnology various carriers such as liposomes, micelles, chitosan, and cyclodextrins are used [21]. Liposomes are carriers composed of phospholipid layer (one or more) and aqueous core with hydrophilic substances dissolved in it [22]. Due to their high affinity to biological cell membranes and ability to transport substances (encapsulation), liposomes easily penetrate the skin or are absorbed through both the oral mucosal lining and through the intestinal wall, wherein they then release the material contained therein [23].…”

Section: Synthesis and Applications Of Nanoparticlesmentioning

confidence: 99%

Agricultural Residues as a Source of Bioactive Substances—Waste Management with the Idea of Circular Economy

Gołębiewska

Kalinowska

2021

Innovations-Sustainability-Modernity-Openness Conference (ISMO’21)

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Every year, the juice industry generates millions of tons of by-products worldwide such as seeds, skins and pomace. This creates significant environmental problems. It is estimated that about 25% of the fruit weight used in juice production is waste. However, even after processing, this waste contains high amounts of valuable bioactive substances. Phenolic compounds and pectin have been found to be the main components of apple pomace and are responsible for its antioxidant, anti-inflammatory, antibacterial, antifungal, and anticancer properties. However, the low bioavailability and sensitivity of some chemicals limit their use in many areas. Advanced extraction techniques and encapsulation of apple pomace extracts is a promising technique to overcome these problems and increasing their applicability (e.g., in the cosmetic, pharmaceutical, or food industries).

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Nanosized Drug Carriers for Oral Delivery of Anticancer Compounds and the Importance of the Chromatographic Techniques

Cited by 13 publications

References 141 publications

Neuronanomedicine: An Up-to-Date Overview

Neuronanomedicine: An Up-to-Date Overview

Step-by-step optimization of the HILIC method for simultaneous determinationof abacavir, lamivudine, and zidovudine from dosage form

Agricultural Residues as a Source of Bioactive Substances—Waste Management with the Idea of Circular Economy

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