Nanosilver-loaded PMMA bone cement doped with different bioactive glasses – evaluation of cytocompatibility, antibacterial activity, and mechanical properties

Wekwejt, Marcin; S, Chen; Kaczmarek-Szczepańska, Beata; Nadolska, Małgorzata; Łukowicz, Krzysztof; Pałubicka, Anna; Michno, Anna; Osyczka, Anna M.; Michálek, Martin; Zieliński, Andrzej

doi:10.1039/d1bm00079a

Cited by 24 publications

(24 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two variants of an experimental AFAMBC were prepared, the first one by mixing particles of a 5 wt/wt% of a bioglass (BGII-0.4; grain size: ≥ 40 mm), Ag NP powder (particle size: approximately 50 nm) (1.5 wt/wt%), and the powder of an approved plain cement brand (BC-BGII-0.4-AgNP cement)[ 68 ]. BGII-0.4 was prepared using the Stober method modified by Zheng et al [ 85 ].…”

Section: Literature Studiesmentioning

confidence: 99%

“…These efforts may be grouped into four approaches: application of an antimicrobial coating to part(s) of implant component(s), such as the proximal zone of the femoral stem of a THA[ 4 , 40 - 45 ]; use of ALBCs in which a relatively new antibiotic/antibacterial compound (for example, daptomycin[ 46 ] or a second-generation lipophosphonoxin[ 47 ]) is added to the cement powder; modification of the surface of the implant (for example, incorporation of an antibiotic-releasing polymer into the surface of a joint implant[ 48 ] and use of a nanofabrication method to create biomimetically-inspired nanostructures on an implant surface[ 49 ]); and proposed use of antibiotic-free antimicrobial PMMA bone cements (AFAMBCs)[ 50 - 68 ]. The focus of the present review is AFAMBCs, which have been the subject of many studies on their formulation and characterization[ 50 - 68 ]. However, to date, only one review of this body of literature has been published[ 69 ] but it has two shortcomings.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antibiotic-free antimicrobial poly (methyl methacrylate) bone cements: A state-of-the-art review

Lewis¹

2022

WJO

View full text Add to dashboard Cite

Prosthetic joint infection (PJI) is the most serious complication following total joint arthroplasty, this being because it is associated with, among other things, high morbidity and low quality of life, is difficult to prevent, and is very challenging to treat/manage. The many shortcomings of antibiotic-loaded poly (methyl methacrylate) (PMMA) bone cement (ALBC) as an agent for preventing and treating/managing PJI are well-known. One is that microorganisms responsible for most PJI cases, such as methicillin-resistant S. aureus , have developed or are developing resistance to gentamicin sulfate, which is the antibiotic in the vast majority of approved ALBC brands. This has led to many research efforts to develop cements that do not contain gentamicin (or, for that matter, any antibiotic) but demonstrate excellent antimicrobial efficacy. There is a sizeable body of literature on these so-called “antibiotic-free antimicrobial” PMMA bone cements (AFAMBCs). The present work is a comprehensive and critical review of this body. In addition to summaries of key trends in results of characterization studies of AFAMBCs, the attractive features and shortcomings of the literature are highlighted. Shortcomings provide motivation for future work, with some ideas being formulation of a new generation of AFAMBCs by, example, adding a nanostructured material and/or an extract from a natural product to the powder and/or liquid of the basis cement, respectively.

show abstract

Section: Literature Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibiotic-free antimicrobial poly (methyl methacrylate) bone cements: A state-of-the-art review

Lewis¹

2022

WJO

View full text Add to dashboard Cite

show abstract

“…Nanosilver can be employed in construction of catheters and tracheal tubes [ 80 , 81 , 82 ]. [ 83 , 84 ] Applicability of nanosilver in dental materials is under study [ 85 , 86 ]. Bandages and dressings containing nanosilver for curing burns [ 87 ], toxic epidermal necrolysis, Steven-Johnson syndrome [ 88 ] and pemphigus [ 89 ] are commercially available.…”

Section: Applicationsmentioning

confidence: 99%

Hyaluronic Acid-Silver Nanocomposites and Their Biomedical Applications: A Review

et al. 2021

View full text Add to dashboard Cite

For the last years scientific community has witnessed a rapid development of novel types of biomaterials, which properties made them applicable in numerous fields of medicine. Although nanosilver, well-known for its antimicrobial, anti-angiogenic, anti-inflammatory and anticancer activities, as well as hyaluronic acid, a natural polysaccharide playing a vital role in the modulation of tissue repair, signal transduction, angiogenesis, cell motility and cancer metastasis, are both thoroughly described in the literature, their complexes are still a novel topic. In this review we introduce the most recent research about the synthesis, properties, and potential applications of HA-nanosilver composites. We also make an attempt to explain the variety of mechanisms involved in their action. Finally, we present biocompatible and biodegradable complexes with bactericidal activity and low cytotoxicity, which properties suggest their suitability for the prophylaxis and therapy of chronic wounds, as well as analgetic therapies, anticancer strategies and the detection of chemical substances and malignant cells. Cited studies reveal that the usage of hyaluronic acid-silver nanocomposites appears to be efficient and safe in clinical practice.

show abstract

“…Intensive research is currently being conducted to improve the thermal, mechanical and biological properties of bone cements [ 16 ]. The research includes doping the cement mass with small amounts of components such as carbon fibers [ 41 ], zirconia fibers [ 42 ], graphite fibers [ 43 ], graphene oxide [ 44 , 45 , 46 , 47 ], bioactive glasses [ 48 ], nanosilver [ 49 ], polydioxanone (PDO) [ 48 ], cellulose [ 48 , 50 , 51 ], mesoporous silica nanoparticles [ 52 , 53 ], aramid [ 54 , 55 ], polyethylene [ 56 ], titanium [ 57 , 58 ], ultra-high molecular weight polyethylene [ 59 ], tricalcium phosphate (TCP) [ 16 , 60 ] or hydroxyapatite (HA) [ 61 , 62 ]. The effect of aging processes associated with the absorption of physiological fluids and the accompanying hydrolysis of polymethylmethacrylate (PMMA) occurring in the outermost layers of the cement are also important, as well as the effect of deviation from the manufacturer’s recommended cement mix ratio [ 63 , 64 , 65 , 66 , 67 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of Selected Physiological Fluid Contaminants on the Mechanical Properties of Selected Medium-Viscosity PMMA Bone Cements

et al. 2022

View full text Add to dashboard Cite

Revision surgeries several years after the implantation of the prosthesis are unfavorable from the patient’s point of view as they expose him to additional discomfort, to risk of complications and are expensive. One of the factors responsible for the aseptic loosening of the prosthesis is the gradual degradation of the cement material as a result of working under considerable loads, in an aggressive environment of the human body. Contaminants present in the surgical field may significantly affect the durability of the bone cement and, consequently, of the entire bone-cement-prosthesis system. The paper presents the results of an analysis of selected mechanical properties of two medium-viscosity bone cements DePuy CMW3 Gentamicin and Heraeus Palamed, for the samples contaminated with saline and blood in the range of 1–10%. The results obtained for compressive strength and modulus of elasticity were subjected to statistical analysis, which estimated the nature of changes in these parameters depending on the amount and type of contamination and their statistical significance.

show abstract

Nanosilver-loaded PMMA bone cement doped with different bioactive glasses – evaluation of cytocompatibility, antibacterial activity, and mechanical properties

Abstract: Nanosilver-loaded PMMA bone cement (BC-AgNp) is a novel cement developed as a replacement for conventional cements. Despite favorable properties and antibacterial activity, BC-AgNp still lacks biodegradability and bioactivity. Hence, we...

Cited by 24 publications

References 70 publications

Antibiotic-free antimicrobial poly (methyl methacrylate) bone cements: A state-of-the-art review

Antibiotic-free antimicrobial poly (methyl methacrylate) bone cements: A state-of-the-art review

Hyaluronic Acid-Silver Nanocomposites and Their Biomedical Applications: A Review

Evaluation of the Effect of Selected Physiological Fluid Contaminants on the Mechanical Properties of Selected Medium-Viscosity PMMA Bone Cements

Contact Info

Product

Resources

About