Nanoscale variation in surface charge of synthetic hydroxyapatite detected by chemically and spatially specific high-resolution force spectroscopy

Vandiver, Jennifer; Dean, Delphine; Patel, N. K.; Bonfield, W.; Ortiz, Christine

doi:10.1016/j.biomaterials.2004.02.053

Cited by 120 publications

(122 citation statements)

References 38 publications

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“…It is known, that in experimental HAP samples OH vacancies occur in high concentration [31,60]. The data are similar for Mn and Se atoms.…”

Section: Exploration Of Influences Of Various Atoms Substitutions In supporting

confidence: 65%

“…These data are confirmed in reference [60], where it was observed that with heating of HAP samples (fabricated by the same PERCERAMICS [15] technology) the OH group is annealed and removed from the HAP surface, which leads to a rise in the energy level Ei ~ Ev+3.5 eV, which the authors of [47] connected with the rise of OH vacancies. As it can be seen, a similar value of energy for OH vacancies case was obtained in [35] (Table 6 and Fig.…”

Section: Dos For O H and Oh Vacancies And H And Oh Interstitialssupporting

confidence: 57%

“…In recent experiments by atomic force microscopy (AFM) using functionalized tips, it has been found that pure HAP mineral surfaces are close to isoelectric at pH = 6 with negative surface charge average of −0.02 C/m 2 and varying between −0.0037 and −0.072 C/m 2 [60], Fig. 17.…”

Section: Main Principles and Features Of Hap Surfaces Charges And Elmentioning

confidence: 97%

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Компьютерные Исследования Наноструктур Гидроксиапатита, Их Особенности И Свойства

Bystrov¹

2017

Math.Biol.Bioinf.

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Abstract. In this review paper the main approaches to modeling the hydroxyapatite (HAP) structures and first-principle calculations of their properties, pure and with various defects, are considered. First, the HAP nano-particles (NPs) and clusters peculiarities are described using different methods: molecular mechanical and quantum mechanical, especially semi-empirical such as PM3. Both approximations used here, namely, restricted Hartee-Fock (RHF) and unrestricted Hartee-Fock (UHF), are considered. The influence of the protons (hydrogens), contained in the surrounding medium (pH), on the formation of HAP nanoparticles of various sizes and shapes is considered and discussed. Second, the HAP crystal unit cells studies are considered on the basis of a density functional theory (DFT) modelling. The main peculiarities of both phases (hexagonal and monoclinic) are considered too, including their ordered and disordered substructures. One of the important aspects of the computer modeling of HAP is to build the models and consider various structural modifications of HAP (such as, vacancies of oxygen atoms and hydroxyl OH group, hydrogen interstitials and different substitutions of atoms in HAP unit cell), which allow explicitly creating and exploring the changes in the charges of HAP and the electrical potential on the HAP surface. HAP modifications are most close to biological HAP and therefore are necessary for implant medical applications and can create and functionalize HAP surface with most adhesive properties for living cells (osteoblasts, osteoclatst). This improves the HAP implant quality. Besides, it has recently been established that oxygen vacancy in HAP influences their photo-catalytic properties. It is important for HAP usage as in environmental remediation and for bacteria inactivation. Therefore it is very important to create and investigate the oxygen vacancy models in HAP, and others defects models. In this work we review a DFT modelling and studies of HAP, both pure perfect bulk and imperfect bulk cases. Special HAP modelling approaches are used for layered slab super-cells units, which include vacuum spaces between the layered slabs forming HAP surface. To all these computer studies the first principle calculations were applied. In this review various DFT approximations are analysed for bulk and surface modified HAP. These approximations are carried out using both the local basis (local density approximation -LDA, in AIMPRO codes) and the plane-waves (generalized gradient approximation -GGA, in VASP codes). Data of all structures and models of HAP defects investigated are widely analyzed.

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“…It is known, that in experimental HAP samples OH vacancies occur in high concentration [31,60]. The data are similar for Mn and Se atoms.…”

Section: Exploration Of Influences Of Various Atoms Substitutions In supporting

confidence: 65%

Section: Dos For O H and Oh Vacancies And H And Oh Interstitialssupporting

confidence: 57%

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Компьютерные Исследования Наноструктур Гидроксиапатита, Их Особенности И Свойства

Bystrov¹

2017

Math.Biol.Bioinf.

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“…Among these ceramics, hydroxyapatite gain more attention being it the prototype in bone as well as tooth apatite crystals, and also one of the main constituents of natural bone. Therefore, its applications as bone implant are being extensively investigated in a different variety of forms (Vandiver et al, 2005). Study conducted by Nakashima et al (2009) showed that there is 48.8% improvement on the remineralization of artificially produced subsurface enamel lesions when the nanosized calcium carbonate particles were incorporated in dentifrices.…”

Section: In Preventionmentioning

confidence: 99%

“…There is an urgent need for the development of improved synthetic materials such as orthopedic implants, that can be used in the event of severe bone damage or lost caused by diseases such as severe periodontitis and osteoporosis (Vandiver et al, 2005).…”

Section: In Dental Restorativementioning

confidence: 99%

Roles of Nanotechnological Approaches in Periodontal Disease Therapy

Aminu¹,

Chan²,

Toh³

2017

J App Pharm Sci

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Formulation scientists are faced with a great hurdle of delivering a therapeutic agent into the periodontal pockets because of the anatomical complexity of the route and the lesion's contours that often leads to poor penetration of the drug to the area. However, recent nanotechnology advancement and innovations through nanodentistry are increasingly providing a suitable solution for the treatment of many dental disorders including periodontal disease. These nanodentistry innovative approaches have vowed to revolutionize dental therapeutics by way of using nanomaterials, biotechnology, and nanorobotics, that can significantly influence and transform dental disease's diagnosis, prevention, and treatment. The advances have offered possibilities for providing highquality dental care to a vast number of people around the globe who are currently suffering from periodontal disease. Novel nanotechnology-based carriers and materials such as polymeric nanoparticles, nanogels, nanopores, nanotubes, scaffold matrices, nanoneedles, nanocrystals, quantum dots, nanofibers, and nanofillers have demonstrated promising efficacy and their roles in the disease therapy are of great significance. The aim of this review article is to provide important recent updates on the various nanotechnology-base approaches for periodontal disease therapy. The roles of these recently investigated approaches in the disease treatment are also covered in the review.

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Nanophase Materials

Ballard

Dulgar-Tulloch

Siegel

2006

Wiley Encyclopedia of Biomedical Engineering

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Great strides are being made in our ability to synthesize and assemble nanoscale building blocks to create nanophase materials with novel properties and functionalities. The novel properties of nanostructures are derived from their confined sizes and their very large surface‐to‐volume ratios. The former give rise to unique size‐dependent properties in the nanoscale (1–100 nm) regime, while the latter give rise to the ability of nanoscale additions to conventional material matrices to dramatically change the host material's properties. Nanostructured surfaces have also been shown to elicit more favorable and selective biomolecule and cellular responses than surfaces at coarser length scales. The characteristics of nanophase materials are described and what is known about their interactions with proteins and cells is reviewed with extensive references. While many studies have been carried out to probe such interactions, we are still at a very early stage of understanding the fundamental issues controlling these interactions. Much careful work remains before these important interactions are fully understood so that they can be controlled to impact biomedicine to benefit society.

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Nanoscale variation in surface charge of synthetic hydroxyapatite detected by chemically and spatially specific high-resolution force spectroscopy

Cited by 120 publications

References 38 publications

Компьютерные Исследования Наноструктур Гидроксиапатита, Их Особенности И Свойства

Компьютерные Исследования Наноструктур Гидроксиапатита, Их Особенности И Свойства

Roles of Nanotechnological Approaches in Periodontal Disease Therapy

Nanophase Materials

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